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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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cobD1Cobalamin biosynthesis transmembrane protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (308 aa)    
Predicted Functional Partners:
cobQ
Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
 
 
 0.951
cobU
Cobinamide kinase/cobinamide phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.
 
 
 0.942
cobC
Cobalamin biosynthesis protein, CobC. CobC is probable involved in the conversion of cobyric acid to cobinamide.Similar to pir|B83486 (48%) and to sprot|COBC_PSEDE (42%). InterPro (PF00155): Aminotransferases class-I and II; Specificity unclear.
 
  
 0.934
cobO
Cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.
 
  
 0.908
cobD2
Putative cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
  
  
 
0.890
azo3529
Probable Precorrin-4 C11-methyltransferase,47% Identity to TrEMBL;Q8GDX1, O26702. SwissProt;O87696. Has PF00590, Tetrapyrrole (Corrin/Porphyrin) Methylases;IPR000878 Cor/por_Metransf; This family uses S-AdoMet in the methylation of diverse substrates. This family includes a related group of bacterial proteins of unknown function, including P45528. This family includes the methylase Dipthine synthase. Uroporphyrin-III C-methyltransferase (EC: 2.1.1.107) (SUMT)catalyzes the transfer of two methyl groups from S-adenosyl-L-methionine to the C-2 and C-7 atoms of uroporphyrinogen III to yiel [...]
 
 
 0.879
azo2781
Conserved hypothetical protein. Homology to ebA1022 of Azoarcus sp. EbN1 of 86% (gnl|keqq|eba:ebA1022(KEGG)). Has PF01923, Cobalamin adenosyltransferase;IPR002779,DUF80; This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation. The EutT enzyme appears to be an adenosyl transferase, converting CNB12 to AdoB12. No signal peptide or TMH present.
    
 0.869
cobB
Cobyrinic acid AC-diamide synthase. Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine and one molecule of ATP is hydrogenolyzed for each amidation (By similarity). cbiA: cobyrinic acid ac-diamide synthase; High confidence in function and specificity.
 
 
 0.766
thlA
Acetyl-CoA acetyltransferase (Acetoacetyl-CoA thiolase):- catalytic activity:-2 acetyl-coa = coa + acetoacetyl-coa. Entry name SWISSPROT:THLA_CLOAB Prim. accession # P45359 Identities = 205/392 (52%) InterPro IPR002155; Thiolase. Pfam PF00108; thiolase; 1. Prediction: Non-secretory protein Signal peptide probability: 0.022 Number of predicted TMHs: 0; Family membership; Belongs to the thiolase-like superfamily. Thiolase family.
       0.755
cbiE
Precorrin-6Y C(5,15)-methyltransferase (decarboxylating); Precorrin-6 methyltransferase (Precorrin-6Y methylase). CATALYZES THE METHYLATION OF BOTH C-5 AND C-15 IN PRECORRIN-6Y TO FORM PRECORRIN-8X. InterPro: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; High confidence in function and specificity.
 
  
 0.663
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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