STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cbiMPutative cobalt transport system, permease protein; Part of the ABC transporter complex cbiKMQO involved in cobalt import. Similar to the cobalt transport membrane protein, CbiM in A. pleuropneumoniae. InterPro: Cobalamin synthesis CBIM cbiM: cobalamin biosynthesis protein Cbi; High confidence in function and specificity. (208 aa)    
Predicted Functional Partners:
cbiQ
Putative cobalt transport system permease protein; Part of the ABC transporter complex cbiKMQO involved in cobalt import. Similar to the cobalt transport membrane protein, CbiQ in A. pleuropneumoniae; Function unclear.
 
 0.997
cbiO
Putative cobalt transport system ATP-binding protein; Part of the ABC transporter complex cbiKMQO involved in cobalt import. Probably responsible for the translocation of the substrate across the membrane. 40% AAA_ATPase.IPR003439; ABC_transporter. Pfam:PF00005; ABC_tran; 1. ProDom; PD000006; ABC_transporter; 1. SMART; SM00382; AAA; 1; High confidence in function and specificity.
 
 0.992
azo2219
Conserved hypothetical membrane protein. Homology to cbiL of Actinobacillus pleuropneumoniae of 39% (gi|5733705|gb|AAD49725.1|(NBCI ENTREZ)). Signal P reproting signal peptide present. TMHMM reporting TMH present; Conserved hypothetical protein.
 
    0.951
azo1044
Conserved hypothetical membrane protein. Homology to ebA4769 of Azoarcus sp. EbN1 of 53% (gnl|keqq|eba:ebA4769(KEGG)). Pfam: Cobalt transport protein. signal peptide. 3 TMHs; Family membership.
  
 0.937
cbiK
Part of the ABC transporter complex cbiKMQO involved in cobalt import. Similar to the putative periplasmic-binding protein CbiK precursor in A.pleuropneumoniae. thiE: thiamine-phosphate pyrophosphoryla; High confidence in function and specificity.
 
  
 0.933
azo2217
Putative TonB-dependent receptor; Similar to FecA, ferric-citrate outer membrane receptor in E.coli, involved in the recognition and internalization of ferric-citrate. InterPro: TonB-dependent receptor protein; Function unclear.
       0.773
cbiE
Precorrin-6Y C(5,15)-methyltransferase (decarboxylating); Precorrin-6 methyltransferase (Precorrin-6Y methylase). CATALYZES THE METHYLATION OF BOTH C-5 AND C-15 IN PRECORRIN-6Y TO FORM PRECORRIN-8X. InterPro: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; High confidence in function and specificity.
  
 
 0.636
cbiGa
Putative Cobalamin (vitamin B12) biosynthesis CbiG protein, truncated. Homology to the N-terminus of cbiG of b. magaterium of 39% (gi|3724046|emb|CAA04315.1|(nr)). Pfam: CibG, CbiG proteins are required for cobalamin (vitamin B 12) biosynthesis. IPR012407: Cobalamin (vitamin B12) biosynthesis CbiG. CbiG is one of the enzymes specific to the anaerobic route of cobalamin biosynthesis e.g., in Salmonella typhimurium. While its specific role in this pathway is not known yet, it has been speculated that CbiG may participate in the conversion of cobalt-precorrin 5 into cobalt-precorrin 6. Th [...]
  
  
 0.551
cbiGb
Putative Cobalamin (vitamin B12) biosynthesis CbiG protein, truncated; C-terminal part of CbiG protein. Cobalamin biosynthesis pathway.Precorrin methylase; High confidence in function and specificity.
  
  
 0.532
azo3529
Probable Precorrin-4 C11-methyltransferase,47% Identity to TrEMBL;Q8GDX1, O26702. SwissProt;O87696. Has PF00590, Tetrapyrrole (Corrin/Porphyrin) Methylases;IPR000878 Cor/por_Metransf; This family uses S-AdoMet in the methylation of diverse substrates. This family includes a related group of bacterial proteins of unknown function, including P45528. This family includes the methylase Dipthine synthase. Uroporphyrin-III C-methyltransferase (EC: 2.1.1.107) (SUMT)catalyzes the transfer of two methyl groups from S-adenosyl-L-methionine to the C-2 and C-7 atoms of uroporphyrinogen III to yiel [...]
  
  
 0.526
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.