Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
azo2308Putative helicase related protein; Hypothetical protein yjiV. TREMBL:Q8XC75: 33% identity, 49% similarity InterPro: IPR001410;DEAD/DEAH box helicase IPR001650; Helicase_C. Pfam: PF00270; DEAD; 1. PF00271; Helicase_C; 1. SMART: SM00487; DEXDc; 1. SM00490; HELICc L18_bact: ribosomal protein L18 No signal peptide No transmembrane helices; High confidence in function and specificity. (2109 aa)    
Predicted Functional Partners:
azo2307
Hypothetical protein, 39% similarity to TrEMBL;Q8Z0Z1. No Signal Peptide or TMH present. TIGR00090: iojap-related protein.
 
     0.950
azo3948
Putative DNA-directed polymerase III; Excinuclease cho (EC 3.1.25.-) (Endonuclease cho) (UvrC homolog protein). Incises the DNA at the 3 side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than uvrC. Not able to incise the 5 site of a lesion. When a lesion remains because uvrC is not able to induce the 3 incision cho incises the DNA. Then uvrC makes the 5 incision. The combined action of cho and uvrC broadens the substrate range of nucleotide excision repair (By similarity); Specificity unclear.
  
  
 0.680
mutM
MutM protein; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  
  
 0.640
azo2309
Conserved hypothetical protein. 61% identity to hypothetical protein Bucepa02000624 [Burkholderia cepacia R1808] (gi|46324486|ref|ZP_00224847.1|(NBCI ENTREZ)). NO Signal peptide or TMH reported present. no domains predicted.
       0.588
radA
Probable DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
   
    0.568
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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