STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo2319Glycosyltransferase; CMP-N-acetylneuraminate-beta-galactosamide-alpha- 23-sialyltransferase (EC 2.4.99.4) (Beta-galactoside alpha-23-sialyltransferase) (Alpha 23-ST) (Gal-NAc6S) (Gal-beta-13-GalNAc-alpha-23-sialyltransferase) (ST3GalIA) (ST3O) (ST3GalA.1) (SIAT4-A) (ST3Gal I). IT MAY BE RESPONSIBLE FOR THE SYNTHESIS OF THE SEQUENCE NEUAC-ALPHA-23-GAL-BETA-13-GALNAC- FOUND ON SUGAR CHAINS O-LINKED TO THR OR SER AND ALSO AS A TERMINAL SEQUENCE ON CERTAIN GANGLIOSIDES. SIAT4-A AND SIAT4-B SIALYLATE THE SAME ACCEPTOR SUBSTRATES BUT EXHIBIT DIFFERENT KM VALUES; Specificity unclear. (207 aa)    
Predicted Functional Partners:
azo2320
Conserved hypothetical protein. Homology to Rsph03001342 of Rhodobacter sphaeroides of 39% (gi|22957735|ref|ZP_00005426.1|(NBCI ENTREZ)). Has PF04230, Polysaccharide pyruvyl transferase;IPR007345 PS_pyruv_trans; Pyruvyl-transferases involved in peptidoglycan-associated polymer biosynthesis. CsaB in Bacillus anthracis is necessary for the non-covalent anchoring of proteins containing an SLH (S-layer homology) domain to peptidoglycan-associated pyruvylated polysaccharides. WcaK and AmsJ are involved in the biosynthesis of colanic acid in Escherichia coli and of amylovoran in Erwinia amyl [...]
 
     0.811
azo2318
Hypothetical membrane protein. homology to rsc2204 of R.solanacearum of 28% (trembl|Q8XXB2(SRS)). no domains predicted. no signal peptide. 10 TMHs.
       0.780
azo2314
Glycosyltransferase; Family membership.
       0.776
msbA1
Lipid A export ATP-binding/permease protein; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
       0.775
azo2315
Conserved hypothetical tyrosine/serine phosphatase,; Conserved hypothetical protein.
       0.773
azo2317
Hypothetical protein predicted by Glimmer/Critica. No homology of the entire protein to the data bank. no dmains predicted. no signal peptide. no TMHs.
       0.773
azo1264
Putative transmembrane sensor protein, no similarity to other bacterial proteins. Best hits to mus musculus and homo sapiens. Domains (LCCL_dom and TIR) are found in proteins (animal and plants) involved in protection against bacterial infection. InterPro: IPR004043 LCCL_dom. IPR000157 TIR. TMHMM reporting 1 transmembrane helices.
  
     0.627
azo2597
Hpyothetical protein with TIR domain. no homology to the data bank. Interpro: TIR domain Pfam: TIR doamin. Site directed mutagenesis and deletion analysis have shown that the TIR domain is essential for Toll and IL-1R activities. Sequence analysis have revealed the presence of three highly conserved regions among the different members of the family: box 1 (FDAFISY), box 2 (GYKLC-RD-PG), and box 3 (a conserved W surrounded by basic residues). It has been proposed that boxes 1 and 2 are involved in the binding of proteins involved in signaling,whereas box 3 is primarily involved in direc [...]
  
     0.544
nqo1
NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Quinone reductase 1) (QR1) (DT-diaphorase) (DTD) (Azoreductase) (Phylloquinone reductase) (Menadione reductase). The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis (By similarity). trembl:Q9I4B4:72%identity; 81% similarity InterPro: NAD(P)H dehydrogenase (quinone) InterPro:IPR003680; NADHdh_2. Pfam:PF02525; Flavo [...]
  
     0.542
flgK
Flagellar hook-filament junction protein 1 (HAP1). no signal peptide no TMHs; High confidence in function and specificity.
  
    0.542
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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