STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo2335RND efflux transporter, permease protein; AcrB/AcrD/AcrF family member. Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer, TREMBL:Q881X7 (44% identity); SWISSPROT:P76399 (48% identity). InterPro (IPR001036): Acriflavin resistance protein Pfam (PF00873): AcrB/AcrD/AcrF family. TIGRFAM (TIGR00915): Hydrophobe/Amphiphile Efflux-1 (HAE1) Family protein. TIGRFAM (TIGR00914): Heavy metal efflux pump, CzcA family. [...] (1044 aa)    
Predicted Functional Partners:
azo2333
Membrane fusion protein; HlyD family secretion protein. The secretion of a number of proteins/molecules require the help of members belonging to the ABC transporter family and a membrane fusion protein belonging to the HlyD family, TREMBL:Q7WF48 (49% identity); TREMBL:Q881X8 (49% identity). Pfam (PF00529): HlyD family secretion protein. TMHMM reporting one transmembrane helix. TC (8.A.1): The Membrane Fusion Protein (MFP) Family; Family membership.
 
 0.984
opcM1
Putative outer membrane efflux protein. Homology to opcM of B. cepacia of 36%. Component of an efflux system that confers multiple antibiotic resistence. Pfam: outer membrane efflux protein signal peptide no TMHs; Family membership.
 
 0.901
azo2568
Membrane fusion protein; HlyD family secretion protein. The secretion of a number of proteins/molecules require the help of members belonging to the ABC transporter family and a membrane fusion protein belonging to the HlyD family,; Family membership.
  
 0.869
azo3135
Membrane fusion protein; HlyD family secretion protein. The secretion of a number of proteins/molecules require the help of members belonging to the ABC transporter family and a membrane fusion protein belonging to the HlyD family, TREMBL:Q7W437 (52% identity); TREMBL:Q8EFT5 (32% identity). InterPro (IPR006143): Secretion protein HlyD. Pfam (PF00529): HlyD family secretion protein. TMHMM reporting one transmembrane helix. TC (8.A.1): The Membrane Fusion Protein (MFP) Family; Family membership.
 
 0.856
azo3376
Membrane fusion protein; HlyD family secretion protein. The secretion of a number of proteins/molecules require the help of members belonging to the ABC transporter family and a membrane fusion protein belonging to the HlyD family. SignalP predicting signal peptide. TC (2.A.6.1): The Heavy Metal Efflux (HME) Family; Family membership.
  
 0.844
azo0846
Membrane fusion protein; Similar to TREMBL:Q7NR61 (35% identity); TREMBL:Q8XYV3 (33% identity); TREMBL:Q88MQ4 (32% identity). InterPro (IPR006143): Secretion protein HlyD. SignalP predicting signal peptide. TC (2.A.6.1): The Heavy Metal Efflux (HME) Family; Family membership; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 0.825
azo0244
Membrane fusion protein; HlyD family secretion protein. The secretion of a number of proteins/molecules require the help of members belonging to the ABC transporter family and a membrane fusion protein belonging to the HlyD family, TREMBL:Q8XRL2 (55% identity); SWISSPROT:P31223 (53% identity). Pfam (PF00529): HlyD family secretion protein. SignalP predicting signal peptide. TC (8.A.1): The Membrane Fusion Protein (MFP) Family; Family membership.
  
 0.800
czcB
Putative membrane fusion protein. Homology to cnrb of A. eutrophus of 30% (pir|F47056). Proteins of the MFP family function as auxiliary proteins or 'adaptors',connecting a primary porter in the cytoplasmic membrane of a Gram-negative bacterium with an outer membrane factor protein that serves a porin or channel function in the outer membrane. In A. eutrophus is this protein involved in cobalt and nickel resistance. No domains predicted. No signal peptide No TMHs; Family membership.
  
 0.799
azo2555
HlyD family secretion protein; Specificity unclear; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 0.786
azo2334
RND efflux transporter, permease protein; AcrB/AcrD/AcrF family protein. Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer,SWISSPROT:P76399 (44% identity). Pfam (PF00873): AcrB/AcrD/AcrF family. TIGRFAM (TIGR00915): Hydrophobe/Amphiphile Efflux-1 (HAE1) Family protein. TIGRFAM (TIGR00914): Heavy metal efflux pump, CzcA family. TMHMM reporting 10 transmembrane helices. TC (2.A.6.2): The (Largely Gram-negative [...]
 
    
0.785
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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