STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
nagIGentisate 1,2-dioxygenase; Involved in catabolism of naphthalene via gentisate to fumarate and pyruvate. NagI is a gentisate 1,2-dioxygenase which converts gentisate to maleylpyruvate. Similar to TREMBL:O86041 (66% identity); TREMBL:Q8X655 (30% identity); TREMBL:Q8Y0F7 (33% identity); High confidence in function and specificity. (345 aa)    
Predicted Functional Partners:
nahG
Salicylate hydroxylase (EC 1.14.13.1) (Salicylate 1-monooxygenase). Similar to TREMBL:Q8Z5B1 (62% identity); TREMBL:Q8X657 (62% identity); TREMBL:Q8ZNM3 (62% identity). Pfam (PF01360): Monooxygenase. TMHMM reporting one transmembrane helix; High confidence in function and specificity.
 
  
 0.951
nagL1
Maleylpyruvate isomerase. Homology to nogL of Ralstonia sp U of 73% (AAD12621) NagL is a reduced glutathione-dependent maleylpyruvate isomerase catalyzing the isomerization of maleylpyruvate to fumarylpyruvate. InterPro: Glutathione S-transferase N terminus (IPR004045) Pfam: Glutathione S-transferase, N-terminale domaine no signal peptide no TMHs; High confidence in function and specificity.
 
  
 0.890
nagL2
Probable maleylpyruvate isomerase. Homology to nagL of Ralstonia spU of 50% (trembl|O86043) NagL is a reduced glutathione-dependent maleylpyruvate isomerase catalyzing the isomerization of maleypyruvate to fumarylpyruvate. InterPro: Glutathione S-transferase N terminus (IPR004045), Glutathione S-transferase C terminus (IPR004046) Pfam: Glutathione S-transferase, N-terminal domaine no signal peptide no TMHs; High confidence in function and specificity.
 
  
 0.787
nagK
Fumarylpyruvate hydrolase; Involved in catabolism of naphthalene via gentisate to fumarate and pyruvate. NagK is a fumarylpyruvate hydrolase which hydrolyzes fumarylpyruvate to fumarate and pyruvate. Similar to TREMBL:O86042 (67% identity); TREMBL:O07877 (63% identity); TREMBL:Q8G387 (50% identity). Pfam (PF01557): Fumarylacetoacetate (FAA) hydrolase family; High confidence in function and specificity.
 
   
 0.732
nagG
Putative ring hydroxylating large subunit; nagG,RSc1090:putative salicylate-5-hydroxylase large oxygenase component oxidoreductase protein [EC:1.-.-.-]. Rieske-type iron-sulfur center homologous to the large subunits of dihydroxylating dioxygenases. Involved in conversion of Naphthalene to gentisate. Aromatic compounds degradation. Biphenyl dioxygenase alpha subunit (EC 1.14.12.18) (Biphenyl 23- dioxygenase); High confidence in function and specificity.
 
   
 0.708
fcbC1
Probable thiesterase; 4-hydroxybenzoyl-CoA thioesterase (EC 3.1.2.23). This family contains a wide variety of enzymes,principally thioesterases. This family includes 4HBT which catalyses the final step in the biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3 InterPro:IPR008272; 4HBcoA_thiost_AS. IPR006683; Thioestr_supf. Pfam:PF03061; 4HBT InterPro: 4-hydroxybenzoyl-CoA thioesterase family active site No signal peptide No transmembrane helices TIGR00051: conserved hypothetical protein; High confidence in function and specificity.
 
     0.673
nahR1
LysR-type transcriptional regulator NahR. Regulates the expression of the naphthalene (nahA-F) and salicylate (nahG-M) metabolism genes. Belongs to the LysR family of transcriptional regulators. Similar to SWISSPROT: sprot|NAHR_PSEPU (40% Pseudomonas putida, hth-type transcriptional activator NahR) Pfam: PF00126 Bacterial regulatory helix-turn-helix protein, lysR family. HTH reporting nucleic acid binding motif; Specificity unclear.
 
     0.628
carBa1
Putative dioxygenase, hydroxylase small component; Ring hydroxylating dioxygenases are multicomponent 1,2-dioxygenase complexes that convert closed-ring structures to non-aromatic cis-diols. The beta subunit is may be responsible for the substrate specificity of the enzyme. Putative 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase, CarBa. Involved in the aerobic degradation of carbazole by P.resinovorans sp. strain CA10. XlyY: Benzene 12-dioxygenase beta subunit (EC 1.14.12.3), involved in benzoate degradation.Degradation of benzoate to 2-hydro-12-dihydroxybenzoate (dhb).; Conserved hypotheti [...]
 
     0.560
azo3053
Conserved hypothetical protein. Homology to an orf of A. evnasii of 79% (trembl|Q84HH9). no domains predicted. no signal peptide. no TMHS.
  
     0.551
carBb1
Putative dioxygenase hydroxylase large component; Ring hydroxylating dioxygenases are multicomponent 1,2-dioxygenase complexes that convert closed-ring structures to non-aromatic cis-diols. Hydroxylase large component of 1,2-dioxygenase protein complex, involved in aromatic compounds degradation. 81% simialr to a Putative 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase, CarBb. Involved in the aerobic degradation of carbazole by Pseudomonas resinovorans sp. strain CA10. TREMBL:Q8GI28 InterPro:IPR005806; Rieske_reg.IPR001663; Ring_hydroxyl_A. Pfam:PF00355; Rieske; 1. PF00848; Ring_hydroxyl_A; [...]
  
     0.541
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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