STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nahGSalicylate hydroxylase (EC 1.14.13.1) (Salicylate 1-monooxygenase). Similar to TREMBL:Q8Z5B1 (62% identity); TREMBL:Q8X657 (62% identity); TREMBL:Q8ZNM3 (62% identity). Pfam (PF01360): Monooxygenase. TMHMM reporting one transmembrane helix; High confidence in function and specificity. (397 aa)    
Predicted Functional Partners:
nagI
Gentisate 1,2-dioxygenase; Involved in catabolism of naphthalene via gentisate to fumarate and pyruvate. NagI is a gentisate 1,2-dioxygenase which converts gentisate to maleylpyruvate. Similar to TREMBL:O86041 (66% identity); TREMBL:Q8X655 (30% identity); TREMBL:Q8Y0F7 (33% identity); High confidence in function and specificity.
 
  
 0.951
iorA
Probable isoquinoline 1-oxidoreductase, alpha subunit Homology to iroA of B. diminuta of 58% (sprot|IORA_BREDI). InterPro: [2Fe-2S] binding domain (IPR002888); Ferredoxin (IPR001041) Pfam: 2FE-2S iron-sulfur cluster binding domein, [2Fe-2S] binding domain no signal peptide no TMHs; Specificity unclear.
  
 
 0.923
azo0325
Putative flavocytochrome protein. 48% FAD_binding_6.IPR001433; Oxred_FAD/NAD(P). Pfam:PF00970; FAD_binding_6; 1.PF00175; NAD_binding_1; 1. TMhelix: 6. Siganl peptide: present; Function unclear.
   
    0.830
xylE
Catechol 2,3-dioxygenase XylE catalyzes the ring cleavage of catechol and some substituted catechols. Similar to pir|JE0112 (52%), to trembl|Q45459 (48%)and to sprot|XYE2_PSEPU (50%). Pfam (PF00903): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily ProDom (PD000977): Extradiol ring-cleavage dioxygenase; Specificity unclear.
    
 0.770
azo1374
This family includes extracellular ligand binding domains of a wide range of receptors and it also includes the bacterial amino acid binding proteins of known structure. Similar to tremblnew|AAR35111 (24%). Pfam (PF01094): Receptor family ligand binding region SignalP reporting Signal peptide; Family membership.
  
    0.692
nagL1
Maleylpyruvate isomerase. Homology to nogL of Ralstonia sp U of 73% (AAD12621) NagL is a reduced glutathione-dependent maleylpyruvate isomerase catalyzing the isomerization of maleylpyruvate to fumarylpyruvate. InterPro: Glutathione S-transferase N terminus (IPR004045) Pfam: Glutathione S-transferase, N-terminale domaine no signal peptide no TMHs; High confidence in function and specificity.
 
   
 0.679
nagK
Fumarylpyruvate hydrolase; Involved in catabolism of naphthalene via gentisate to fumarate and pyruvate. NagK is a fumarylpyruvate hydrolase which hydrolyzes fumarylpyruvate to fumarate and pyruvate. Similar to TREMBL:O86042 (67% identity); TREMBL:O07877 (63% identity); TREMBL:Q8G387 (50% identity). Pfam (PF01557): Fumarylacetoacetate (FAA) hydrolase family; High confidence in function and specificity.
  
  
 0.669
nagAa
Naphthalene 12-dioxygenase system ferredoxin--NAD(+) reductase component COMPONENT OF NAPHTHALENE DIOXYGENASE (NDO) MULTICOMPONENT ENZYME SYSTEM WHICH CATALYZES THE INCORPORATION OF BOTH ATOMS OF MOLECULAR OXYGEN INTO NAPHTHALENE TO FORM CIS- NAPHTHALENE DIHYDRODIOL. TRANSFERS ELECTRONS FROM FERREDOXIN (NDOA) TO NADH; High confidence in function and specificity.
     
 0.658
amiC1
Aliphatic amidase expression-regulating protein,AmiC regulates the expression of the inducible aliphatic amidase activity in Pseudomonas aeruginosa. Similar to sprot|AMIC_PSEAE (31%) and to trembl|P74390 (50%).Pfam (PF01094): Receptor family ligand binding region SignalP reporting Signal peptide; Specificity unclear.
   
    0.638
amiC2
Putative aliphatic amidase expression-regulating protein; AmiC regulates the expression of the inducible aliphatic amidase activity in Pseudomonas aeruginosa. Similar to trembl|Q87VQ0 (80%) and to sprot|AMIC_PSEAE (27%). Pfam (PF01094): Receptor family ligand binding region SignalP reporting Signal peptide; Specificity unclear.
   
    0.638
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.