STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nagL1Maleylpyruvate isomerase. Homology to nogL of Ralstonia sp U of 73% (AAD12621) NagL is a reduced glutathione-dependent maleylpyruvate isomerase catalyzing the isomerization of maleylpyruvate to fumarylpyruvate. InterPro: Glutathione S-transferase N terminus (IPR004045) Pfam: Glutathione S-transferase, N-terminale domaine no signal peptide no TMHs; High confidence in function and specificity. (213 aa)    
Predicted Functional Partners:
hppD
Probable 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) (4HPPD) (HPD) (HPPDase). Homology to hppD of Pseudomonas sp. of 56% (pir|S21209) Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2. Pfam: Glaxolase/Bleomycin resistance protein no signal peptide no TMHs; Family membership.
 
 
 0.908
nagK
Fumarylpyruvate hydrolase; Involved in catabolism of naphthalene via gentisate to fumarate and pyruvate. NagK is a fumarylpyruvate hydrolase which hydrolyzes fumarylpyruvate to fumarate and pyruvate. Similar to TREMBL:O86042 (67% identity); TREMBL:O07877 (63% identity); TREMBL:Q8G387 (50% identity). Pfam (PF01557): Fumarylacetoacetate (FAA) hydrolase family; High confidence in function and specificity.
 
 
 0.900
nagI
Gentisate 1,2-dioxygenase; Involved in catabolism of naphthalene via gentisate to fumarate and pyruvate. NagI is a gentisate 1,2-dioxygenase which converts gentisate to maleylpyruvate. Similar to TREMBL:O86041 (66% identity); TREMBL:Q8X655 (30% identity); TREMBL:Q8Y0F7 (33% identity); High confidence in function and specificity.
 
  
 0.893
azo3678
This family consists of fumarylacetoacetate (FAA) hydrolase, or fumarylacetoacetate hydrolase (FAH) and it also includes HHDD isomerase/OPET decarboxylase from E. coli strain W. Similar to TREMBL:Q9KSB3 (67% identity); TREMBL:Q92LT4 (67% identity); TREMBL:Q8EGD4 (61% identity). Pfam (PF01557): Fumarylacetoacetate (FAA) hydrolase family; Family membership.
 
 
 0.855
leuS
Leucine--tRNA ligase; Unnamed protein product; Region start changed from 3544790 to 3544922 (-132 bases); Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 0.807
lysS
Lysyl-tRNA synthetase (EC 6.1.1.6) (Lysine--tRNA ligase) (LysRS); High confidence in function and specificity; Belongs to the class-II aminoacyl-tRNA synthetase family.
   
  0.802
azo2485
Conserved hypothetical protein. Homology to eca2717 of E. carotovora of 35% (tremble:Q6D3M7). no domains predicted. no signal peptide. no TMHs.
   
  0.802
proS
Proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacy [...]
   
  0.772
metG
MetG protein; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
    
 0.756
argS
Putative arginine-tRNA ligase (EC 6.1.1.19). Homology to argS of E. coli of 25% (sprot:SYR_ECOLI) CATALYTIC ACTIVITY: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). InterPro: Arginyl-tRNA synthetase (IPR001278); Aminoacyl-transfer RNA synthetase class-I (IPR001412) Tigrfam: argS: arginyl-tRNA synthetase Pfam: tRNA synthetases class I no signal peptide no TMHs; Family membership.
   
  0.749
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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