azo2427 protein (Azoarcus sp. BH72) - STRING interaction network

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azo2427

Conserved hypothetical membrane protein. Homology to BB1720 of Bordetella bronchiseptica of 32% (trembl|Q7WLM5). Has PF03992, Antibiotic biosynthesis monooxygenase;IPR007138;This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 (Q9X9W3) is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue. TMHMM2 reporting 2 TMH's Present. No Signal Peptide present; Conserved hypothetical protein. (196 aa)

Predicted Functional Partners:

azo2433

0.511

azo2428

0.495

bleO

0.422

azo1952

0.411

aphS

0.410

xylE

0.400

Your Current Organism:

Azoarcus sp. BH72

NCBI taxonomy Id: 62928
Other names: A. sp. BH72

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
aphS	azo2427	azo2437	azo2427	Transcriptional regulator,; High confidence in function and specificity.	Conserved hypothetical membrane protein. Homology to BB1720 of Bordetella bronchiseptica of 32% (trembl\|Q7WLM5). Has PF03992, Antibiotic biosynthesis monooxygenase;IPR007138;This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 (Q9X9W3) is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue. TMHMM2 reporting 2 TMH's Present. No Signal Peptide present; Conserved hypothetical protein.	0.410
aphS	azo2433	azo2437	azo2433	Transcriptional regulator,; High confidence in function and specificity.	The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases,TREMBL:Q8XUP8 (61% identity); TREMBL:Q9I400 (57% identity). InterPro (IPR002198): Short-chain dehydrogenase/reductase (SDR) superfamily. InterPro (IPR002347): Glucose/ribitol dehydrogenase. Pfam (PF00106): Short chain dehydrogenase; Specificity unclear.	0.526
aphS	xylE	azo2437	azo1858	Transcriptional regulator,; High confidence in function and specificity.	Catechol 2,3-dioxygenase XylE catalyzes the ring cleavage of catechol and some substituted catechols. Similar to pir\|JE0112 (52%), to trembl\|Q45459 (48%)and to sprot\|XYE2_PSEPU (50%). Pfam (PF00903): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily ProDom (PD000977): Extradiol ring-cleavage dioxygenase; Specificity unclear.	0.429
azo1952	azo2427	azo1952	azo2427	Conserved hypothetical secreted protein. Homology to Daro03003313 of Dechloromonas aromatica of 60% (gi\|53729649\|ref\|ZP_00149978.2\|(NBCI ENTREZ)). Has PF06980, Protein of unknown function (DUF1302);IPR010727,DUF1302;This family contains a number of hypothetical bacterial proteins of unknown function that are approximately 600 residues long. Most family members seem to be from Pseudomonas. Signal peptide present. No TMHs; Conserved hypothetical protein.	Conserved hypothetical membrane protein. Homology to BB1720 of Bordetella bronchiseptica of 32% (trembl\|Q7WLM5). Has PF03992, Antibiotic biosynthesis monooxygenase;IPR007138;This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 (Q9X9W3) is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue. TMHMM2 reporting 2 TMH's Present. No Signal Peptide present; Conserved hypothetical protein.	0.411
azo2427	aphS	azo2427	azo2437	Conserved hypothetical membrane protein. Homology to BB1720 of Bordetella bronchiseptica of 32% (trembl\|Q7WLM5). Has PF03992, Antibiotic biosynthesis monooxygenase;IPR007138;This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 (Q9X9W3) is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue. TMHMM2 reporting 2 TMH's Present. No Signal Peptide present; Conserved hypothetical protein.	Transcriptional regulator,; High confidence in function and specificity.	0.410
azo2427	azo1952	azo2427	azo1952	Conserved hypothetical membrane protein. Homology to BB1720 of Bordetella bronchiseptica of 32% (trembl\|Q7WLM5). Has PF03992, Antibiotic biosynthesis monooxygenase;IPR007138;This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 (Q9X9W3) is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue. TMHMM2 reporting 2 TMH's Present. No Signal Peptide present; Conserved hypothetical protein.	Conserved hypothetical secreted protein. Homology to Daro03003313 of Dechloromonas aromatica of 60% (gi\|53729649\|ref\|ZP_00149978.2\|(NBCI ENTREZ)). Has PF06980, Protein of unknown function (DUF1302);IPR010727,DUF1302;This family contains a number of hypothetical bacterial proteins of unknown function that are approximately 600 residues long. Most family members seem to be from Pseudomonas. Signal peptide present. No TMHs; Conserved hypothetical protein.	0.411
azo2427	azo2428	azo2427	azo2428	Conserved hypothetical membrane protein. Homology to BB1720 of Bordetella bronchiseptica of 32% (trembl\|Q7WLM5). Has PF03992, Antibiotic biosynthesis monooxygenase;IPR007138;This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 (Q9X9W3) is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue. TMHMM2 reporting 2 TMH's Present. No Signal Peptide present; Conserved hypothetical protein.	Conserved hypothetical secreted protein. Homology to an orf of T. aromatica of 48% (trembl\|Q7B0A2). no domains. signal peptide. no TMHs; Conserved hypothetical protein.	0.495
azo2427	azo2433	azo2427	azo2433	Conserved hypothetical membrane protein. Homology to BB1720 of Bordetella bronchiseptica of 32% (trembl\|Q7WLM5). Has PF03992, Antibiotic biosynthesis monooxygenase;IPR007138;This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 (Q9X9W3) is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue. TMHMM2 reporting 2 TMH's Present. No Signal Peptide present; Conserved hypothetical protein.	The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases,TREMBL:Q8XUP8 (61% identity); TREMBL:Q9I400 (57% identity). InterPro (IPR002198): Short-chain dehydrogenase/reductase (SDR) superfamily. InterPro (IPR002347): Glucose/ribitol dehydrogenase. Pfam (PF00106): Short chain dehydrogenase; Specificity unclear.	0.511
azo2427	bleO	azo2427	azo3713	Conserved hypothetical membrane protein. Homology to BB1720 of Bordetella bronchiseptica of 32% (trembl\|Q7WLM5). Has PF03992, Antibiotic biosynthesis monooxygenase;IPR007138;This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 (Q9X9W3) is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue. TMHMM2 reporting 2 TMH's Present. No Signal Peptide present; Conserved hypothetical protein.	Putative bleomycin resistance protein; Bleomycin (Blm) is a glycopeptide antibiotic produced naturally by actinomycetes. It is a strong DNA-cutting agent and thus finds use as a potent anti-cancer drug. Actinomycetes have developed a defence mechanism against this lethal compound, producing a protein that confers resistance to Blm through drug sequestering.Putative Bleomycin resistance protein,; Family membership.	0.422
azo2427	xylE	azo2427	azo1858	Conserved hypothetical membrane protein. Homology to BB1720 of Bordetella bronchiseptica of 32% (trembl\|Q7WLM5). Has PF03992, Antibiotic biosynthesis monooxygenase;IPR007138;This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 (Q9X9W3) is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue. TMHMM2 reporting 2 TMH's Present. No Signal Peptide present; Conserved hypothetical protein.	Catechol 2,3-dioxygenase XylE catalyzes the ring cleavage of catechol and some substituted catechols. Similar to pir\|JE0112 (52%), to trembl\|Q45459 (48%)and to sprot\|XYE2_PSEPU (50%). Pfam (PF00903): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily ProDom (PD000977): Extradiol ring-cleavage dioxygenase; Specificity unclear.	0.400
azo2428	azo2427	azo2428	azo2427	Conserved hypothetical secreted protein. Homology to an orf of T. aromatica of 48% (trembl\|Q7B0A2). no domains. signal peptide. no TMHs; Conserved hypothetical protein.	Conserved hypothetical membrane protein. Homology to BB1720 of Bordetella bronchiseptica of 32% (trembl\|Q7WLM5). Has PF03992, Antibiotic biosynthesis monooxygenase;IPR007138;This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 (Q9X9W3) is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue. TMHMM2 reporting 2 TMH's Present. No Signal Peptide present; Conserved hypothetical protein.	0.495
azo2433	aphS	azo2433	azo2437	The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases,TREMBL:Q8XUP8 (61% identity); TREMBL:Q9I400 (57% identity). InterPro (IPR002198): Short-chain dehydrogenase/reductase (SDR) superfamily. InterPro (IPR002347): Glucose/ribitol dehydrogenase. Pfam (PF00106): Short chain dehydrogenase; Specificity unclear.	Transcriptional regulator,; High confidence in function and specificity.	0.526
azo2433	azo2427	azo2433	azo2427	The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases,TREMBL:Q8XUP8 (61% identity); TREMBL:Q9I400 (57% identity). InterPro (IPR002198): Short-chain dehydrogenase/reductase (SDR) superfamily. InterPro (IPR002347): Glucose/ribitol dehydrogenase. Pfam (PF00106): Short chain dehydrogenase; Specificity unclear.	Conserved hypothetical membrane protein. Homology to BB1720 of Bordetella bronchiseptica of 32% (trembl\|Q7WLM5). Has PF03992, Antibiotic biosynthesis monooxygenase;IPR007138;This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 (Q9X9W3) is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue. TMHMM2 reporting 2 TMH's Present. No Signal Peptide present; Conserved hypothetical protein.	0.511
azo2433	xylE	azo2433	azo1858	The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases,TREMBL:Q8XUP8 (61% identity); TREMBL:Q9I400 (57% identity). InterPro (IPR002198): Short-chain dehydrogenase/reductase (SDR) superfamily. InterPro (IPR002347): Glucose/ribitol dehydrogenase. Pfam (PF00106): Short chain dehydrogenase; Specificity unclear.	Catechol 2,3-dioxygenase XylE catalyzes the ring cleavage of catechol and some substituted catechols. Similar to pir\|JE0112 (52%), to trembl\|Q45459 (48%)and to sprot\|XYE2_PSEPU (50%). Pfam (PF00903): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily ProDom (PD000977): Extradiol ring-cleavage dioxygenase; Specificity unclear.	0.520
bleO	azo2427	azo3713	azo2427	Putative bleomycin resistance protein; Bleomycin (Blm) is a glycopeptide antibiotic produced naturally by actinomycetes. It is a strong DNA-cutting agent and thus finds use as a potent anti-cancer drug. Actinomycetes have developed a defence mechanism against this lethal compound, producing a protein that confers resistance to Blm through drug sequestering.Putative Bleomycin resistance protein,; Family membership.	Conserved hypothetical membrane protein. Homology to BB1720 of Bordetella bronchiseptica of 32% (trembl\|Q7WLM5). Has PF03992, Antibiotic biosynthesis monooxygenase;IPR007138;This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 (Q9X9W3) is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue. TMHMM2 reporting 2 TMH's Present. No Signal Peptide present; Conserved hypothetical protein.	0.422
xylE	aphS	azo1858	azo2437	Catechol 2,3-dioxygenase XylE catalyzes the ring cleavage of catechol and some substituted catechols. Similar to pir\|JE0112 (52%), to trembl\|Q45459 (48%)and to sprot\|XYE2_PSEPU (50%). Pfam (PF00903): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily ProDom (PD000977): Extradiol ring-cleavage dioxygenase; Specificity unclear.	Transcriptional regulator,; High confidence in function and specificity.	0.429
xylE	azo2427	azo1858	azo2427	Catechol 2,3-dioxygenase XylE catalyzes the ring cleavage of catechol and some substituted catechols. Similar to pir\|JE0112 (52%), to trembl\|Q45459 (48%)and to sprot\|XYE2_PSEPU (50%). Pfam (PF00903): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily ProDom (PD000977): Extradiol ring-cleavage dioxygenase; Specificity unclear.	Conserved hypothetical membrane protein. Homology to BB1720 of Bordetella bronchiseptica of 32% (trembl\|Q7WLM5). Has PF03992, Antibiotic biosynthesis monooxygenase;IPR007138;This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 (Q9X9W3) is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue. TMHMM2 reporting 2 TMH's Present. No Signal Peptide present; Conserved hypothetical protein.	0.400
xylE	azo2433	azo1858	azo2433	Catechol 2,3-dioxygenase XylE catalyzes the ring cleavage of catechol and some substituted catechols. Similar to pir\|JE0112 (52%), to trembl\|Q45459 (48%)and to sprot\|XYE2_PSEPU (50%). Pfam (PF00903): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily ProDom (PD000977): Extradiol ring-cleavage dioxygenase; Specificity unclear.	The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases,TREMBL:Q8XUP8 (61% identity); TREMBL:Q9I400 (57% identity). InterPro (IPR002198): Short-chain dehydrogenase/reductase (SDR) superfamily. InterPro (IPR002347): Glucose/ribitol dehydrogenase. Pfam (PF00106): Short chain dehydrogenase; Specificity unclear.	0.520

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