STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nahOAcetaldehyde dehydrogenase; Involved in naphthalene degradation. Similar to TREMBL:Q52039 (83% identity); TREMBL:Q9ZI57 (76% identity); SWISPROT:P77580 (52% identity). InterPro (IPR003361): Acetaldehyde dehydrogenase Pfam (PF02396): Acetaldehyde dehydrogenase; High confidence in function and specificity. (306 aa)    
Predicted Functional Partners:
nahM
4-hydroxy 2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
 
 0.991
lapG
4-hydroxy 2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
 
 0.971
mhpE
4-hydroxy 2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
 
 0.967
nahK
4-Oxalocrotonate decarboxylase; Similar to TREMBL:Q93JW1 (67% identity); TREMBL:Q9RHN0 (67% identity); SWISSPROT:P49155 (59% identity). Pfam (PF01689): Hydratase/decarboxylase; High confidence in function and specificity.
 
  
 0.960
nahL
2-oxopent-4-enoate hydratase; Conversion of 2-hydroxypent-2,4-dienoate into 4-hydroxy-2-oxopentanoate. Meta-cleavage pathway for the degradation of phenols, cresols and catechol. Belongs to the todj/xyli/xylj/hpcg family. Similar to TREMBL:Q93JW5 (75% identity); TREMBL:Q9ZI58 (65% identity); SWISSPROT:P23107 (73% identity). InterPro (IPR002607): Hydratase/decarboxylase Pfam (PF01689): Hydratase/decarboxylase; High confidence in function and specificity.
 
  
 0.930
leuA1
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
 0.897
leuA2
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
 0.897
nifV
Homocitrate synthase is involved in the biosynthesis of the iron-molybdenum cofactor of nitrogenase and catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate into homocitrate. Similar to sprot|NIFV_AZOVI (51%) and to sprot|NIV1_ANASP (42%). Pfam (PF00682): HMG-CoA Lyase-like family InterPro (PS00815): Alpha-isopropylmalate and homocitrate synthase; High confidence in function and specificity; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 0.878
mhpD
MhpD protein; This family consist of various hydratases and 4-oxalocrotonate decarboxylases which are involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds, TREMBL:Q51981 (54% identity); SWISSPROT:P77608 (50% identity). InterPro (IPR002607): Hydratase/decarboxylase Pfam (PF01689): Hydratase/decarboxylase; High confidence in function and specificity.
 
  
 0.870
lapE
2-oxopent-4-enoate hydratase; Conversion of 2-hydroxypent-2,4-dienoate into 4-hydroxy-2-oxopentanoate, involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds. Belongs to the todj/xyli/xylj/hpcg family, TREMBL:Q93JW5 (62% identity); SWISSPROT:P23107 (58% identity). Pfam (PF01689): Hydratase/decarboxylase; High confidence in function and specificity.
 
  
 0.868
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.