Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
poxBProbable Phenol hydroxylase, subunit P1,65% identity(69% similarity) to TrEMBL;Q7WYF3 LapL [lapL] [Pseudomonas sp. KL28]. Has PF02332;Methane/Phenol/Toluene Hydroxylase domain;IPR003430: Bacterial phenol hydroxylase (EC: 1.14.13.7) is a multicomponent enzyme that catabolises phenol and some of its methylated derivatives. This family contains both the P1 and P3 polypeptides of phenol hydroxlase and the alpha and beta chain of methane hydroxylase protein A. Methane hydroxylase protein A (EC: 1.14.13.25) is responsible for the initial oxygenation of methane to methanol in methanotrophs. I [...] (331 aa)    
Predicted Functional Partners:
poxC
Probable phenol hydrolase, subunit P2. Catabolizes phenol and some of its methylated derivatives. p2 is required for growth on phenol, and for in vitro phenol hydroxylase activity. Similar to SWISSPROT:P19731 (47% similarity,71% identity). Pfam (PF02406): MmoB/DmpM family; High confidence in function and specificity.
 
 
  0.986
poxD
Probable phenol hydroxylase subunit,68% identity(84% similarity) to trEMBL:Q9RAF6,Phenol hydroxylase component [phyC] [Ralstonia sp. KN1]. TrEMBL;Q9ZNP4 Has PF02332:Methane/Phenol/Toluene Hydroxylase;IPR003430;Bacterial phenol hydroxylase (EC: 1.14.13.7) is a multicomponent enzyme that catabolises phenol and some of its methylated derivatives. This family contains both the P1 and P3 polypeptides of phenol hydroxlase and the alpha and beta chain of methane hydroxylase protein A. Methane hydroxylase protein A (EC: 1.14.13.25) is responsible for the initial oxygenation of methane to metha [...]
 
 
 0.982
poxE
Probable phenol hydroxylase, subunit P4; Pseudomonas sp. phenol hydroxylase P4 protein (EC 1.14.13.7, (phenol 2-monooxygenase P4 component). CATABOLIZES PHENOL AND SOME OF ITS METHYLATED DERIVATIVES. P4 IS REQUIRED FOR GROWTH ON PHENOL AND FOR IN VITRO PHENOL HYDROXYLASE ACTIVITY; High confidence in function and specificity.
 
 
  0.975
lapO
Phenol 2-monooxygenase p4 component,; High confidence in function and specificity.
 
 
  0.957
lapN
Phenol 2-monooxygenase p3 component,; High confidence in function and specificity.
 
 
 0.946
lapM
Phenol 2-monooxygenase p2 component,; High confidence in function and specificity.
 
 
  0.943
lapP
Phenol hydroxylase P5 protein (EC 1.14.13.7) (Phenol 2-monooxygenase P5 component). Probable electron transfer from NADPH via FAD and the 2Fe-2S center to the oxygenase activity site of the enzyme; High confidence in function and specificity.
 
  
  0.943
poxF
Probable phenol hydroxylase (EC 1.14.13.7) (Phenol 2-monooxygenase P5 component). Probable electron transfer from NADPH via FAD and the 2Fe-2S center to the oxygenase activity site of the enzyme. InterPro: Oxidoreductase FAD and NAD(P)-binding domain hisT_truA: tRNA pseudouridine synthase A; Specificity unclear.
 
  
  0.943
poxA
Putative phenol hydroxylase, subunit P0. Homology to poxA of R. eutropha of 34% (trembl:O84958) This family consists of several bacterial phenol hydroxylase subunit proteins which are part of a multicomponent phenol hydroxylase. Some bacteria can utilise phenol or some of its methylated derivatives as their sole source of carbon and energy. The first step in this process is the conversion of phenol into catechol. Catechol is then further metabolised via the meta-cleavage pathway into TCA cycle intermediates. Pfam: Phenol hydrolase subunit no signal peptide no TMHs; Family membership.
 
  
  0.936
lapK
Phenol 2-monooxygenase p0 component,; High confidence in function and specificity.
 
  
  0.922
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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