| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ahpC | cmd | azo0769 | azo2506 | Alkyl hydroperoxide reductase subunit C; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. | 4-carboxymuconolactone decarboxylase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | 0.459 |
| azo1264 | cmd | azo1264 | azo2506 | Putative transmembrane sensor protein, no similarity to other bacterial proteins. Best hits to mus musculus and homo sapiens. Domains (LCCL_dom and TIR) are found in proteins (animal and plants) involved in protection against bacterial infection. InterPro: IPR004043 LCCL_dom. IPR000157 TIR. TMHMM reporting 1 transmembrane helices. | 4-carboxymuconolactone decarboxylase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | 0.424 |
| azo1421 | cmd | azo1421 | azo2506 | TREMBLNEW:CAE27009: Probable carboxylesterase, 50% identity, 60% similarity. Dihydrolipoamide acetyltransferase component of acetoin cleaving system (EC 2.3.1.12) (Acetoin dehydrogenase E2 component). InterPro: Alpha/beta hydrolase fold: IPR000073; A/b_hydrolase. IPR003089; AB_hydrolase. IPR000379; Ser_estrs. Pfam PF00561; Abhydrolase_1 InterPro: Alpha/beta hydrolase fold kdgT: 2-keto-3-deoxygluconate permease; Family membership. | 4-carboxymuconolactone decarboxylase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | 0.476 |
| azo2505 | cmd | azo2505 | azo2506 | Putative TetR family transcriptional regulator,; Family membership. | 4-carboxymuconolactone decarboxylase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | 0.597 |
| azo2663 | cmd | azo2663 | azo2506 | Conserved hypothetical peroxiredoxin; Conserve peroxiredoxin. Homology to mll2432 of M. loti of 74% (trembl|Q98IF0). Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic fatty acid and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. Pfam: AhpC/TSA family no TMHs. No signal peptide; Family membership. | 4-carboxymuconolactone decarboxylase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | 0.459 |
| cmd | ahpC | azo2506 | azo0769 | 4-carboxymuconolactone decarboxylase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | Alkyl hydroperoxide reductase subunit C; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. | 0.459 |
| cmd | azo1264 | azo2506 | azo1264 | 4-carboxymuconolactone decarboxylase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | Putative transmembrane sensor protein, no similarity to other bacterial proteins. Best hits to mus musculus and homo sapiens. Domains (LCCL_dom and TIR) are found in proteins (animal and plants) involved in protection against bacterial infection. InterPro: IPR004043 LCCL_dom. IPR000157 TIR. TMHMM reporting 1 transmembrane helices. | 0.424 |
| cmd | azo1421 | azo2506 | azo1421 | 4-carboxymuconolactone decarboxylase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | TREMBLNEW:CAE27009: Probable carboxylesterase, 50% identity, 60% similarity. Dihydrolipoamide acetyltransferase component of acetoin cleaving system (EC 2.3.1.12) (Acetoin dehydrogenase E2 component). InterPro: Alpha/beta hydrolase fold: IPR000073; A/b_hydrolase. IPR003089; AB_hydrolase. IPR000379; Ser_estrs. Pfam PF00561; Abhydrolase_1 InterPro: Alpha/beta hydrolase fold kdgT: 2-keto-3-deoxygluconate permease; Family membership. | 0.476 |
| cmd | azo2505 | azo2506 | azo2505 | 4-carboxymuconolactone decarboxylase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | Putative TetR family transcriptional regulator,; Family membership. | 0.597 |
| cmd | azo2663 | azo2506 | azo2663 | 4-carboxymuconolactone decarboxylase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | Conserved hypothetical peroxiredoxin; Conserve peroxiredoxin. Homology to mll2432 of M. loti of 74% (trembl|Q98IF0). Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic fatty acid and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. Pfam: AhpC/TSA family no TMHs. No signal peptide; Family membership. | 0.459 |
| cmd | pcaC | azo2506 | azo3958 | 4-carboxymuconolactone decarboxylase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | Carboxymuconolactone decarboxylase family protein,65% Identity (78% similarity) to TrEMBL;Q8EKK9. Has PF02627, Carboxymuconolactone decarboxylase family; IPR003779, CMD: Carboxymuconolactone decarboxylase (CMD)is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins (e.g. O67982) CMD represents the C-terminal domain, Abhydrolase_1 represents the N-terminal domain; High confidence in function and specificity. | 0.532 |
| cmd | pobR1 | azo2506 | azo2447 | 4-carboxymuconolactone decarboxylase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | pobR. Transcriptional regulator AraC family. InterPro: AraC type helix-turn-helix pdxH: pyridoxamine 5-phosphate oxidase; Function unclear. | 0.434 |
| cmd | purB | azo2506 | azo0901 | 4-carboxymuconolactone decarboxylase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | Adenylosuccinate lyase (Adenylosuccinase) (ASL); High confidence in function and specificity; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.510 |
| cmd | sigZ | azo2506 | azo2962 | 4-carboxymuconolactone decarboxylase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | Putative RNA polymerase sigma factor sigZ. The sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released. Similar to SWISSPROT: sprot|SIGZ_BACSU (23% Bacillus subtilis, RNA polymerase sigma factor SigZ) / sprot|RPSH_PSEAE (28% Pseudomonas aeruginosa, RNA polymerase sigma-h factor (sigma-30), AlgU or AlgT) InterPro: IPR000838 Sigma70_ECF. Pfam: PF07638 ECF sigma factor; High confidence in function and specificity. | 0.694 |
| cmd | ybdK | azo2506 | azo2276 | 4-carboxymuconolactone decarboxylase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | Glutamate-cysteine ligase; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. | 0.440 |
| pcaC | cmd | azo3958 | azo2506 | Carboxymuconolactone decarboxylase family protein,65% Identity (78% similarity) to TrEMBL;Q8EKK9. Has PF02627, Carboxymuconolactone decarboxylase family; IPR003779, CMD: Carboxymuconolactone decarboxylase (CMD)is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins (e.g. O67982) CMD represents the C-terminal domain, Abhydrolase_1 represents the N-terminal domain; High confidence in function and specificity. | 4-carboxymuconolactone decarboxylase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | 0.532 |
| pcaC | pobR1 | azo3958 | azo2447 | Carboxymuconolactone decarboxylase family protein,65% Identity (78% similarity) to TrEMBL;Q8EKK9. Has PF02627, Carboxymuconolactone decarboxylase family; IPR003779, CMD: Carboxymuconolactone decarboxylase (CMD)is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins (e.g. O67982) CMD represents the C-terminal domain, Abhydrolase_1 represents the N-terminal domain; High confidence in function and specificity. | pobR. Transcriptional regulator AraC family. InterPro: AraC type helix-turn-helix pdxH: pyridoxamine 5-phosphate oxidase; Function unclear. | 0.448 |
| pcaC | purB | azo3958 | azo0901 | Carboxymuconolactone decarboxylase family protein,65% Identity (78% similarity) to TrEMBL;Q8EKK9. Has PF02627, Carboxymuconolactone decarboxylase family; IPR003779, CMD: Carboxymuconolactone decarboxylase (CMD)is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins (e.g. O67982) CMD represents the C-terminal domain, Abhydrolase_1 represents the N-terminal domain; High confidence in function and specificity. | Adenylosuccinate lyase (Adenylosuccinase) (ASL); High confidence in function and specificity; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.662 |
| pobR1 | cmd | azo2447 | azo2506 | pobR. Transcriptional regulator AraC family. InterPro: AraC type helix-turn-helix pdxH: pyridoxamine 5-phosphate oxidase; Function unclear. | 4-carboxymuconolactone decarboxylase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. | 0.434 |
| pobR1 | pcaC | azo2447 | azo3958 | pobR. Transcriptional regulator AraC family. InterPro: AraC type helix-turn-helix pdxH: pyridoxamine 5-phosphate oxidase; Function unclear. | Carboxymuconolactone decarboxylase family protein,65% Identity (78% similarity) to TrEMBL;Q8EKK9. Has PF02627, Carboxymuconolactone decarboxylase family; IPR003779, CMD: Carboxymuconolactone decarboxylase (CMD)is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins (e.g. O67982) CMD represents the C-terminal domain, Abhydrolase_1 represents the N-terminal domain; High confidence in function and specificity. | 0.448 |
