STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fldAHypothetical protein FldA, 78% identity (86% similarity) to TrEMBL;Q6N0R5,Q8PF30(47% identity). 45% identity to ybhH of SwissProt;P75762(E.coli) Has PF04303,Protein of unknown function (DUF453);IPR007400; FldA (Q9L3A0) is thought to be involved in the degradation of the polyaromatic hydrocarbon fluorene by Sphingomonas sp. LB126. Has PF01678, Diaminopimelate epimerase;IPR001653 DAP_epimerase: Diaminopimelate epimerase contains two domains of the same alpha/beta fold, both contained in this family.Diaminopimelate epimerase (EC:5.1.1.7) catalyzes the isomeriazation of L,L- to D,L-meso-di [...] (360 aa)    
Predicted Functional Partners:
ligI
Probable 2-pyrone-4,6-dicarboxylate hydrolase. Homology to ligI of S. paucimobilis of 55% (tremble:O87170) Pfam: Amidohydrolase no signal peptide no TMHs; High confidence in function and specificity.
 
  
 0.948
fldW
4-oxalomesaconate hydratase These proteins are related to the metal-dependent hydrolase superfamily tremblnew|CAE30137: 86% identity, 93% similarity InterPro:IPR006992; Amidohydro_2. Pfam:PF04909; Amidohydro_2 Absence of traansmembrane helices (TMHMM predicted); High confidence in function and specificity.
 
  
 0.947
acnA
Probable aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 
 0.931
azo2541
Acyl transferase, putative; Possible acyl transferase; Family membership.
 
   
 0.892
ligB2
Protocatechuate 4,5-dioxygenase beta chain subunit,having 91% similarity(85% identity)to TrEMBL;Q6N0Q9,Protocatechuate 3,4-dioxygenase beta chain [pcaH] [Xanthomonas axonopodis (pv. citri)]Swiss-Prot: P22636;PF02900;IPR004183; Catalytic LigB subunit of aromatic ring-opening dioxygenase.The LigAB enzyme (a protocatechuate 4,5-dioxygenase EC: 1.13.11.8), of Sphingomonas paucimobilis oxidizes protocatechuate (or 3,4-dihydroxybenzoic acid, PCA). The enzyme belongs to the class III extradiol-type catecholic dioxygenase family,which catalyzes the ring-opening reaction of protocatechuate and [...]
 
  
 0.869
ligA2
[EC:1.13.11.8], Protocatechuate 4,5-dioxygenase alpha chain (EC 1.13.11.8) (4,5-PCD)., Aromatic-ring-opening dioxygenase LigAB, LigA subunit; High confidence in function and specificity.
 
  
 0.858
ligB1
Protocatechuate 4,5-dioxygenase beta chain subunit,having 63% similarity(48% identity)to TrEMBL;Q8PP10,Protocatechuate 3,4-dioxygenase beta chain [pcaH] [Xanthomonas axonopodis (pv. citri)] Swiss-Prot: P22636 PF02900;IPR004183; Catalytic LigB subunit of aromatic ring-opening dioxygenase.The LigAB enzyme (a protocatechuate 4,5-dioxygenase EC: 1.13.11.8), of Sphingomonas paucimobilis oxidizes protocatechuate (or 3,4-dihydroxybenzoic acid, PCA). The enzyme belongs to the class III extradiol-type catecholic dioxygenase family,which catalyzes the ring-opening reaction of protocatechuate and [...]
 
  
 0.843
mmsB
Putative 3-hydroxyisobutyrate dehydrogenase; Activity:- 3-hydroxy-2-methylpropanoate + NAD = 2-methyl-3-oxopropanoate + NADH2 Entry name SWISSPROT:MMSB_PSEAE InterPro IPR002204; 3hydroxisobut_dh. IPR006115; 6PGD_NAD. Pfam PF03446; NAD_binding_2; 1. Identities = 48/218 (22%) Prediction: Non-secretory protein Signal peptide probability: 0.000 Number of predicted TMHs: 0; Family membership.
 
    0.842
ligA1
Protocatechuate 4,5-dioxygenase alpha subunit, 39% Identity to TrEMBL;Q6N0R0,Q6NB24, Q9KWL5. Has PF07746Aromatic-ring-opening dioxygenase LigAB, LigA subunit; TMHMM2 reports 1 TMH.
 
  
 0.803
azo0952
Conserved hypothetical protein, 38% identity (50% similarity) to TrEMBL;Q7WXG4 Signal Peptide Present.TMH not Present. Has PF04471:Restriction endonuclease;(IPR007560:Mrr_cat):Prokaryotic family found in type II restriction enzymes containing the hallmark (D/E)-(D/E)XK active site. Presence of catalytic residues implicates this region in the enzymatic cleavage of DNA. PF01396:Topoisomerase DNA binding C4 zinc finger;(IPR000380 DNA_tpisomrase):Prokaryotic topoisomerase I, otherwise known as relaxing enzyme,untwisting enzyme or swivelase, catalyses the ATP-independent breakage of single- [...]
   
  
 0.789
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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