STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bcr1Bicyclomycin resistance protein homolog. Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase (By similarity). InterPro: General substrate transporters efflux_Bcr_CflA: drug resistance tran Also show similarity to bssH of bssDCABEFGH operon-genes involved in anaerobic degradation of toulene in denitryfing bacterium, Azoarcus strain EbN1; High confidence in function and specificity. (413 aa)    
Predicted Functional Partners:
nac
Nitrogen assimilation regulatory protein nac (Nitrogen assimilation control protein). TRANSCRIPTIONAL ACTIVATOR FOR THE HUT PUT AND URE OPERONS AND REPRESSOR FOR THE GDH AND GLTB OPERONS IN RESPONSE TO NITROGEN LIMITATION. NEGATIVE REGULATOR OF ITS OWN EXPRESSION. Similar to SWISSPROT: sprot|NAC_KLEAE (30% Klebsiella aerogenes, nitrogen assimilation regulatory protein nac (nitrogen assimilation control protein)) Pfam: PF00126 Bacterial regulatory helix-turn-helix protein, lysR family. HTH reporting nucleic acid binding motif; Specificity unclear.
 
     0.636
azo2303
Conserved hypothetical membrane protein. Homology to Daro03002720 of Dechloromonas aromatica of 55% (gi|41723618|ref|ZP_00150528.1|(NBCI ENTREZ)). Permease,member of the Major Facilitator Superfamiliy (MFS)transporters.MFS are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients. Similar to proteins involved in tetracycline resistance. Hypothetical transport protein yhcA, from B.subtilis. InterPro: Drug resistance transporter EmrB/QacA subfamily efflux_EmrB: drug resistance transport. Signal peptide predicted. 13 TMH [...]
  
   
 0.563
fldA
Hypothetical protein FldA, 78% identity (86% similarity) to TrEMBL;Q6N0R5,Q8PF30(47% identity). 45% identity to ybhH of SwissProt;P75762(E.coli) Has PF04303,Protein of unknown function (DUF453);IPR007400; FldA (Q9L3A0) is thought to be involved in the degradation of the polyaromatic hydrocarbon fluorene by Sphingomonas sp. LB126. Has PF01678, Diaminopimelate epimerase;IPR001653 DAP_epimerase: Diaminopimelate epimerase contains two domains of the same alpha/beta fold, both contained in this family.Diaminopimelate epimerase (EC:5.1.1.7) catalyzes the isomeriazation of L,L- to D,L-meso-di [...]
       0.503
pheA
Bifunctional chorismate mutase/prephenate dehydratase P-protein, pheA,; High confidence in function and specificity.
    
 0.491
pcaK
PcaK:4-hydroxybenzoate transporter. TRANSPORTER FOR 4-HYDROXYBENZOATE ALSO REQUIRED FOR CHEMOTAXIS TO AROMATIC ACIDS. Membership of the major facilitator superfamily of transport proteins. 2A0115: benzoate transport; High confidence in function and specificity.
    
 0.454
pabB
Para-aminobenzoate synthase component I (EC 4.1.3.-) (ADC synthase). CATALYZES THE BIOSYNTHESIS OF 4-AMINO-4-DEOXYCHORISMATE (ADC) FROM CHORISMATE AND GLUTAMINE. InterPro: Anthranilate synthase component I and chorismate binding enzyme pabB: para-aminobenzoate synthase component I; Specificity unclear.
   
 
 0.453
aas
AAS bifunctional protein [Includes: 2-acylglycerophosphoethanolamine acyltransferase (2-acyl-GPE acyltransferase); Acyl-acyl carrier protein synthetase (Acyl-ACP synthetase)]. PLAYS A ROLE IN LYSOPHOSPHOLIPID ACYLATION. TRANSFERS FATTY ACIDS TO THE 1-POSITION VIA AN ENZYME-BOUND ACYL-ACP INTERMEDIATE IN THE PRESENCE OF ATP AND MG(2+). ITS PHYSIOLOGICAL FUNCTION IS TO REGENERATE PTDETN FROM 2-ACYL-GPE FORMED BY TRANSACYLATION REACTIONS OR DEGRADATION BY PHOSPHOLIPASE A1, TREMBL:Q8FEA6 (52% identity); SWISSPROT:P31119 (52% identity). Pfam (PF00501): AMP-binding enzyme. Pfam (PF01553): Ac [...]
  
 
 0.436
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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