Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
azo2555HlyD family secretion protein; Specificity unclear; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (254 aa)    
Predicted Functional Partners:
nodT
Putative outer membrane efflux protein. Homology to nodT from Rhizobium leguminosarum of 20% over 432 aa. The OEP family (Outer membrane efflux protein)allow export of a variety of substrates in Gram negative bacteria. Most members of NodT family are likely to export primarily small molecules rather than proteins. InterPro: Outer membrane efflux protein. Pfam: Outer membrane efflux protein Signal peptide no TMHs; Family membership.
 
  0.985
macB
ATP-binding/permease fusion ABC transporter; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP- binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 0.953
azo2557
HlyD family secretion protein; Similar to MacA; Family membership.
 
  
  0.938
tolC
Putative outer membrane effluxe protein protein. Homology to tolC from E. coli of 33%. The OEP family (outer membreane effluxe protein) allow export of a variety of substrates in Gram negative bacteria. TolC is believed to be a membre af an ABC transporter system for protein secretion without cleavage of a signal sequence. Pfam: Outer membrane efflux protein Signal peptide no TMHs; Family membership.
  
 0.919
azo2558
Membrane protein with HlyD domain; Family membership.
 
  
  0.909
aggA
Putative outer membrane efflux protein. Homology to aggA from P. putida of 35%. The OEP family (outer membrane efflux protein) allow export of a variety of substrates in Gram negative bacteria. InterPro: Outer membrane efflux protein Pfam: Outer membrane efflux protein signal peptide no TMHs; Function unclear.
 
 0.872
macA
Periplasmic component of efflux system; Macrolide-specific efflux protein macA precursor. Efflux transporter for macrolide antibiotics (By similarity). Membrane Fusion Protein (MFP) family; High confidence in function and specificity.
  
  
  0.860
azo3376
Membrane fusion protein; HlyD family secretion protein. The secretion of a number of proteins/molecules require the help of members belonging to the ABC transporter family and a membrane fusion protein belonging to the HlyD family. SignalP predicting signal peptide. TC (2.A.6.1): The Heavy Metal Efflux (HME) Family; Family membership.
  
  
 
0.859
azo0224
Hypotethical outer membrane efflux protein. Homology to PA2525 of P. aeruginosa of 25%. signal peptide. no TMHs.
   
  0.857
azo3134
RND efflux transporter, permease protein; AcrB/AcrD/AcrF family. Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer, TREMBL:Q9HW27 (38% identity); SWISSPROT:Q57124 (33% identity). InterPro (IPR001036): Acriflavin resistance protein. Pfam (PF00873): AcrB/AcrD/AcrF family. TIGRFAM (TIGR00915): Hydrophobe/Amphiphile Efflux-1 (HAE1) Family protein. TIGRFAM (TIGR00914): Heavy metal efflux pump, CzcA family. TMHMM [...]
 
 0.850
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.