STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fsrA gene conferring resistance to fosmidomycin (Fs) encode a putative polypeptide of 406 amino acids (aa) with a molecular weight of 43303 in E.coli. 23% similarity to B. japonicum fsr. A comparison between the aa sequence of Fsr and sequences in a protein database revealed 18% homology to the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. Hydropathy analysis of the Fsr protein revealed twelve putative transmembrane segments. Fsr does not have any direct effect on the biosynthesis of isoprenoid in E. coli, and that the mechanism for FsR involv [...] (412 aa)    
Predicted Functional Partners:
azo2386
Conserved hypothetical membrane protein. Homology to BB4221 of Bordetella bronchiseptica of 32% (trembl|Q7WFQ0). Has PF07331, Protein of unknown function (DUF1468);IPR009936;This family consists of several hypothetical bacterial proteins of around 150 residues in length. The function of this family is unknown. Signal peptide. 3 TMHs; Conserved hypothetical protein.
  
     0.673
azo2574
Putative AraC-family transcriptional regulator,; Family membership.
 
     0.621
azo2571
Conserved hypothetical protein. Homology to VV1824 of V.vulnificus of 37% (trembl:Q7MKG9). No domains predicted. No signal peptide or TMH reported present.
       0.551
azo2572
Hypothetical membrane protein. no homology to the data bank. no domains predicted. no signal peptide. 1 TMHs.
       0.551
fbpA2
Part of the ABC transporter complex FbpABC involved in ferric import. Similar to the putative periplasmic-binding protein FbpA precursor in A. pleuropneumoniae. 39% SBP_bac_1. Pfam:PF01547; SBP_bac_1; 1. Signal peptide:1 TMHelix:1; Specificity unclear.
 
    0.493
azo1638
Putative exported protein, 39% identity (54% similarity)to TrEMBL;Q7VUI5 TrEMBL;Q7WNJ8. Has PF03401;Bordetella uptake gene (bug) product;(IPR005064)These probable extra-cytoplasmic solute receptors are strongly overrepresented in several beta-proteobacteria. SIgnal Peptide Present. No TMH reported present; Specificity unclear.
  
     0.477
pheA
Bifunctional chorismate mutase/prephenate dehydratase P-protein, pheA,; High confidence in function and specificity.
   
 
 0.436
azo3693
Similar to hypothetical integral membrane transport protein yidY (MFS family). Signal peptide containing non secretory protein. With 12 putative transmembrane helices. General transport of carbohydrates, amino acids, and other small molecules; Conserved hypothetical protein.
  
  
 0.431
fbpA1
Iron (III)-transport system, substrate-binding protein FbpA. Part of the ABC transporter complex fbpABC (TC 3.A.1.10.1) involved in ferric cations import.Iron(III)periplasmic binding protein component; High confidence in function and specificity.
  
    0.422
pgtC
Putative regulatory lipoprotein; Phosphoglycerate transport regulatory protein pgtC precursor.Required for pgtP expression it may act jointly with the pgtA/pgtB signaling proteins.29% SBP_bac_1: Bacterial extracellular solute-binding protein family 1. Pfam:PF01547; SBP_bac_1; 1. Signal peptide:present; High confidence in function and specificity.
  
    0.422
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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