hemH protein (Azoarcus sp. BH72) - STRING interaction network

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hemH

Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (363 aa)

Predicted Functional Partners:

azo3494

0.928

coxD

0.903

cyaY

0.895

hemE

0.890

azo2583

0.781

hrcA

0.747

sdhB

0.694

azo1870

0.692

clpP

0.692

azo2630

0.670

Your Current Organism:

Azoarcus sp. BH72

NCBI taxonomy Id: 62928
Other names: A. sp. BH72

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
azo1870	hemH	azo1870	azo2582	Endopeptidase Clp; Putative protease encoded ATP-dependent Clp protease family protein similar(30 Identity,45% similarity in function) to TrEMBL:Q8X866. IPR001907. Has pfam00574,CLP_protease, Clp protease. The Clp protease has an active site catalytic triad. In E. coli Clp protease, ser-111,his-136 and asp-185 form the catalytic triad. One member has lost all of these active site residues and is therefore inactive. Some members contain one or two large insertions. Peptidase family S49 domain present. Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a [...]	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.	0.692
azo1870	sdhB	azo1870	azo1552	Endopeptidase Clp; Putative protease encoded ATP-dependent Clp protease family protein similar(30 Identity,45% similarity in function) to TrEMBL:Q8X866. IPR001907. Has pfam00574,CLP_protease, Clp protease. The Clp protease has an active site catalytic triad. In E. coli Clp protease, ser-111,his-136 and asp-185 form the catalytic triad. One member has lost all of these active site residues and is therefore inactive. Some members contain one or two large insertions. Peptidase family S49 domain present. Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a [...]	Succinate dehydrogenase, iron-sulfur subunit. Homology to sdhB of C. burnetii of 59% (sprot\|DHSB_COXBU). InterPro: Succinate dehydrogenase/fumarate reductase iron-sulfur protein (IPR004489); 4fe-4S ferredoxin, iron-sulfur binding domain (IPR001450); Ferredoxin (IPR1041) Pfam: 2Fe-2S iron-sulfur cluster binding domain Tigrfam: dhsB: succinate dehydrogenase and fumarat reductase iron-sulfur protein no TMHs; High confidence in function and specificity.	0.656
azo2583	hemH	azo2583	azo2582	Conserved hypothetical membrane protein. Homology to rs02279 of R. solanacearum of 53% (trembl\|Q8Y388(SRS)). No domains predicted. No signal peptide. 4 TMHs; Conserved hypothetical protein.	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.	0.781
azo2583	hrcA	azo2583	azo2581	Conserved hypothetical membrane protein. Homology to rs02279 of R. solanacearum of 53% (trembl\|Q8Y388(SRS)). No domains predicted. No signal peptide. 4 TMHs; Conserved hypothetical protein.	Heat-inducible transcriptional repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.	0.664
azo2630	azo3494	azo2630	azo3494	Cobalamin biosynthesis protein, putative; CobN Magnesium Chelatase family protein, by similarity; Family membership.	Conserved hypothetical membrane protein. Homology to CV0155 of Chromobacterium violaceum of 69% (trembl\|Q7P1Q8). Has PF03653, Uncharacterised protein family (UPF0093);IPR005265, Cons_hypoth701:It appears the conserved hypothetical integral membrane proteins of this family are found only in gram negative bacteria and their function is unknown. No signal peptide. 4 TMHs; Conserved hypothetical protein.	0.513
azo2630	hemH	azo2630	azo2582	Cobalamin biosynthesis protein, putative; CobN Magnesium Chelatase family protein, by similarity; Family membership.	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.	0.670
azo3494	azo2630	azo3494	azo2630	Conserved hypothetical membrane protein. Homology to CV0155 of Chromobacterium violaceum of 69% (trembl\|Q7P1Q8). Has PF03653, Uncharacterised protein family (UPF0093);IPR005265, Cons_hypoth701:It appears the conserved hypothetical integral membrane proteins of this family are found only in gram negative bacteria and their function is unknown. No signal peptide. 4 TMHs; Conserved hypothetical protein.	Cobalamin biosynthesis protein, putative; CobN Magnesium Chelatase family protein, by similarity; Family membership.	0.513
azo3494	hemH	azo3494	azo2582	Conserved hypothetical membrane protein. Homology to CV0155 of Chromobacterium violaceum of 69% (trembl\|Q7P1Q8). Has PF03653, Uncharacterised protein family (UPF0093);IPR005265, Cons_hypoth701:It appears the conserved hypothetical integral membrane proteins of this family are found only in gram negative bacteria and their function is unknown. No signal peptide. 4 TMHs; Conserved hypothetical protein.	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.	0.928
clpP	hemH	azo2071	azo2582	Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.	0.692
clpP	sdhB	azo2071	azo1552	Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Succinate dehydrogenase, iron-sulfur subunit. Homology to sdhB of C. burnetii of 59% (sprot\|DHSB_COXBU). InterPro: Succinate dehydrogenase/fumarate reductase iron-sulfur protein (IPR004489); 4fe-4S ferredoxin, iron-sulfur binding domain (IPR001450); Ferredoxin (IPR1041) Pfam: 2Fe-2S iron-sulfur cluster binding domain Tigrfam: dhsB: succinate dehydrogenase and fumarat reductase iron-sulfur protein no TMHs; High confidence in function and specificity.	0.656
coxD	hemH	azo3294	azo2582	Putative protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.	0.903
coxD	sdhB	azo3294	azo1552	Putative protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.	Succinate dehydrogenase, iron-sulfur subunit. Homology to sdhB of C. burnetii of 59% (sprot\|DHSB_COXBU). InterPro: Succinate dehydrogenase/fumarate reductase iron-sulfur protein (IPR004489); 4fe-4S ferredoxin, iron-sulfur binding domain (IPR001450); Ferredoxin (IPR1041) Pfam: 2Fe-2S iron-sulfur cluster binding domain Tigrfam: dhsB: succinate dehydrogenase and fumarat reductase iron-sulfur protein no TMHs; High confidence in function and specificity.	0.469
cyaY	hemH	azo3652	azo2582	Putative CyaY protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.	0.895
cyaY	sdhB	azo3652	azo1552	Putative CyaY protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.	Succinate dehydrogenase, iron-sulfur subunit. Homology to sdhB of C. burnetii of 59% (sprot\|DHSB_COXBU). InterPro: Succinate dehydrogenase/fumarate reductase iron-sulfur protein (IPR004489); 4fe-4S ferredoxin, iron-sulfur binding domain (IPR001450); Ferredoxin (IPR1041) Pfam: 2Fe-2S iron-sulfur cluster binding domain Tigrfam: dhsB: succinate dehydrogenase and fumarat reductase iron-sulfur protein no TMHs; High confidence in function and specificity.	0.669
hemE	hemH	azo3979	azo2582	Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.	0.890
hemH	azo1870	azo2582	azo1870	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.	Endopeptidase Clp; Putative protease encoded ATP-dependent Clp protease family protein similar(30 Identity,45% similarity in function) to TrEMBL:Q8X866. IPR001907. Has pfam00574,CLP_protease, Clp protease. The Clp protease has an active site catalytic triad. In E. coli Clp protease, ser-111,his-136 and asp-185 form the catalytic triad. One member has lost all of these active site residues and is therefore inactive. Some members contain one or two large insertions. Peptidase family S49 domain present. Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a [...]	0.692
hemH	azo2583	azo2582	azo2583	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.	Conserved hypothetical membrane protein. Homology to rs02279 of R. solanacearum of 53% (trembl\|Q8Y388(SRS)). No domains predicted. No signal peptide. 4 TMHs; Conserved hypothetical protein.	0.781
hemH	azo2630	azo2582	azo2630	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.	Cobalamin biosynthesis protein, putative; CobN Magnesium Chelatase family protein, by similarity; Family membership.	0.670
hemH	azo3494	azo2582	azo3494	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.	Conserved hypothetical membrane protein. Homology to CV0155 of Chromobacterium violaceum of 69% (trembl\|Q7P1Q8). Has PF03653, Uncharacterised protein family (UPF0093);IPR005265, Cons_hypoth701:It appears the conserved hypothetical integral membrane proteins of this family are found only in gram negative bacteria and their function is unknown. No signal peptide. 4 TMHs; Conserved hypothetical protein.	0.928
hemH	clpP	azo2582	azo2071	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.	Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.692