STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo2597Hpyothetical protein with TIR domain. no homology to the data bank. Interpro: TIR domain Pfam: TIR doamin. Site directed mutagenesis and deletion analysis have shown that the TIR domain is essential for Toll and IL-1R activities. Sequence analysis have revealed the presence of three highly conserved regions among the different members of the family: box 1 (FDAFISY), box 2 (GYKLC-RD-PG), and box 3 (a conserved W surrounded by basic residues). It has been proposed that boxes 1 and 2 are involved in the binding of proteins involved in signaling,whereas box 3 is primarily involved in direc [...] (531 aa)    
Predicted Functional Partners:
azo2596
Hypothetical secreted protein. no homology to the data bank. no domains predicted. signal peptide. no TMHs.
       0.741
azo2595
Conserved hypothetical secreted protein. Homology to Daro03002422 of Dechloromonas aromatica of 63% (gi|41723835|ref|ZP_00150725.1|(NBCI ENTREZ)). No domains predicted. No TMHs. signal peptide present; Conserved hypothetical protein.
       0.673
azo2591
Conserved hypothetical secreted protein. Homology to Daro03002418 of Dechloromonas aromatica of 58% (gi|53730135|ref|ZP_00150721.2|(NBCI ENTREZ)). No domains predicted. No TMHs. signal peptide present.
 
     0.619
azo2593
Conserved hypothetical secreted protein. Homology to Daro03002420 of Dechloromonas aromatica of 39% (gi|41723833|ref|ZP_00150723.1|(NBCI ENTREZ)). no domains predicted. signal peptide. no TMHs; Conserved hypothetical protein.
       0.616
azo2594
Conserved hypothetical membrane protein. Homology to CV2219 of Chromobacterium violaceum of 36% (trembl|Q7NVX2(SRS)). no domains predicted. no signal peptide. 1 TMHs; Conserved hypothetical protein.
       0.616
azo2592
Conserved hypothetical protein. Homology to Daro03002419 of Dechloromonas aromatica of 51% (gi|41723832|ref|ZP_00150722.1|(NBCI ENTREZ)). no domains predicted. no signal peptide. no TMHs.
       0.574
azo2319
Glycosyltransferase; CMP-N-acetylneuraminate-beta-galactosamide-alpha- 23-sialyltransferase (EC 2.4.99.4) (Beta-galactoside alpha-23-sialyltransferase) (Alpha 23-ST) (Gal-NAc6S) (Gal-beta-13-GalNAc-alpha-23-sialyltransferase) (ST3GalIA) (ST3O) (ST3GalA.1) (SIAT4-A) (ST3Gal I). IT MAY BE RESPONSIBLE FOR THE SYNTHESIS OF THE SEQUENCE NEUAC-ALPHA-23-GAL-BETA-13-GALNAC- FOUND ON SUGAR CHAINS O-LINKED TO THR OR SER AND ALSO AS A TERMINAL SEQUENCE ON CERTAIN GANGLIOSIDES. SIAT4-A AND SIAT4-B SIALYLATE THE SAME ACCEPTOR SUBSTRATES BUT EXHIBIT DIFFERENT KM VALUES; Specificity unclear.
  
     0.544
azo1264
Putative transmembrane sensor protein, no similarity to other bacterial proteins. Best hits to mus musculus and homo sapiens. Domains (LCCL_dom and TIR) are found in proteins (animal and plants) involved in protection against bacterial infection. InterPro: IPR004043 LCCL_dom. IPR000157 TIR. TMHMM reporting 1 transmembrane helices.
  
     0.497
azo2598
Conserved hypothetical secreted protein. Homology to SMb20495 of S.meliloti of 45% (tremble:Q92W68). Has 3 TPR repeats(IPR001440)(SMART:SM00028):The tetratrico peptide repeat (TPR) is a structural motif present in a wide range of proteins. It mediates protein-protein interactions and the assembly of multiprotein complexes. The TPR motif consists of 3 tandem-repeats of 34 amino acids residues, although individual TPR motifs can be dispersed in the protein sequence. Sequence alignment of the TPR domains reveals a consensus sequence defined by a pattern of small and large amino acids. TPR [...]
       0.449
hppD
Probable 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) (4HPPD) (HPD) (HPPDase). Homology to hppD of Pseudomonas sp. of 56% (pir|S21209) Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2. Pfam: Glaxolase/Bleomycin resistance protein no signal peptide no TMHs; Family membership.
  
  
 0.444
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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