| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| azo0728 | metH | azo0728 | azo3726 | Bifunctional DGTP-pyrophosphohydrolase/Thiamine-phosphate diphosphorylase; NUDIX hydrolase/thiamine phosphate synthase Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate (THZ-P) and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity). InterPro: NUDIX hydrolase TIGRFAM: mutt: mutator mutT protein; High confidence in function and specificity. | Probable methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.772 |
| azo0728 | nadE | azo0728 | azo1360 | Bifunctional DGTP-pyrophosphohydrolase/Thiamine-phosphate diphosphorylase; NUDIX hydrolase/thiamine phosphate synthase Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate (THZ-P) and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity). InterPro: NUDIX hydrolase TIGRFAM: mutt: mutator mutT protein; High confidence in function and specificity. | NAD(+) synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.830 |
| azo0728 | nudJ | azo0728 | azo2774 | Bifunctional DGTP-pyrophosphohydrolase/Thiamine-phosphate diphosphorylase; NUDIX hydrolase/thiamine phosphate synthase Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate (THZ-P) and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity). InterPro: NUDIX hydrolase TIGRFAM: mutt: mutator mutT protein; High confidence in function and specificity. | Conserved hypothetical protein; Putative Nudix hydrolase ymfB (EC 3.6.-.-). mutt: mutator mutT protein; Specificity unclear; Belongs to the Nudix hydrolase family. NudJ subfamily. | 0.601 |
| azo2773 | azo2776 | azo2773 | azo2776 | Conserved hypothetical secreted protein. Homology to ebA988 of Azoarcus sp. EbN1 of 43% (gnl|keqq|eba:ebA988(KEGG)). no domains predicted. signal peptie. no TMHs; Conserved hypothetical protein. | Hypothetical protein, 47% identity to TrEMBL;Q7NW97,TrEMBL;Q7VTV4(56% identity). No domains,repeats, motifs or features present; Function unclear. | 0.635 |
| azo2773 | ilvE2 | azo2773 | azo2775 | Conserved hypothetical secreted protein. Homology to ebA988 of Azoarcus sp. EbN1 of 43% (gnl|keqq|eba:ebA988(KEGG)). no domains predicted. signal peptie. no TMHs; Conserved hypothetical protein. | Branched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.608 |
| azo2773 | mnmA | azo2773 | azo2772 | Conserved hypothetical secreted protein. Homology to ebA988 of Azoarcus sp. EbN1 of 43% (gnl|keqq|eba:ebA988(KEGG)). no domains predicted. signal peptie. no TMHs; Conserved hypothetical protein. | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | 0.815 |
| azo2773 | nudJ | azo2773 | azo2774 | Conserved hypothetical secreted protein. Homology to ebA988 of Azoarcus sp. EbN1 of 43% (gnl|keqq|eba:ebA988(KEGG)). no domains predicted. signal peptie. no TMHs; Conserved hypothetical protein. | Conserved hypothetical protein; Putative Nudix hydrolase ymfB (EC 3.6.-.-). mutt: mutator mutT protein; Specificity unclear; Belongs to the Nudix hydrolase family. NudJ subfamily. | 0.836 |
| azo2776 | azo2773 | azo2776 | azo2773 | Hypothetical protein, 47% identity to TrEMBL;Q7NW97,TrEMBL;Q7VTV4(56% identity). No domains,repeats, motifs or features present; Function unclear. | Conserved hypothetical secreted protein. Homology to ebA988 of Azoarcus sp. EbN1 of 43% (gnl|keqq|eba:ebA988(KEGG)). no domains predicted. signal peptie. no TMHs; Conserved hypothetical protein. | 0.635 |
| azo2776 | ilvE2 | azo2776 | azo2775 | Hypothetical protein, 47% identity to TrEMBL;Q7NW97,TrEMBL;Q7VTV4(56% identity). No domains,repeats, motifs or features present; Function unclear. | Branched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.802 |
| azo2776 | mnmA | azo2776 | azo2772 | Hypothetical protein, 47% identity to TrEMBL;Q7NW97,TrEMBL;Q7VTV4(56% identity). No domains,repeats, motifs or features present; Function unclear. | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | 0.542 |
| azo2776 | nudJ | azo2776 | azo2774 | Hypothetical protein, 47% identity to TrEMBL;Q7NW97,TrEMBL;Q7VTV4(56% identity). No domains,repeats, motifs or features present; Function unclear. | Conserved hypothetical protein; Putative Nudix hydrolase ymfB (EC 3.6.-.-). mutt: mutator mutT protein; Specificity unclear; Belongs to the Nudix hydrolase family. NudJ subfamily. | 0.570 |
| fimV1 | nudJ | azo1043 | azo2774 | Putative type 4 pilus biogenesis; In Pseudomonas aeruginosa, FimV ist probable involved in remodelling of the peptidoglycan layer to enable assembly of the type IV fimbrial structure and machinery. And it is also required for twitching motility. Similar to trembl|O87015 (28%). Pfam (PF01476): LysM domain Pfam (PF04102): SlyX, may be a coiled-coil structure SignalP reporting Signal peptide; Function unclear. | Conserved hypothetical protein; Putative Nudix hydrolase ymfB (EC 3.6.-.-). mutt: mutator mutT protein; Specificity unclear; Belongs to the Nudix hydrolase family. NudJ subfamily. | 0.623 |
| fumB | nadE | azo2415 | azo1360 | Putative fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | NAD(+) synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.756 |
| fumB | nudJ | azo2415 | azo2774 | Putative fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Conserved hypothetical protein; Putative Nudix hydrolase ymfB (EC 3.6.-.-). mutt: mutator mutT protein; Specificity unclear; Belongs to the Nudix hydrolase family. NudJ subfamily. | 0.625 |
| ilvE2 | azo2773 | azo2775 | azo2773 | Branched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Conserved hypothetical secreted protein. Homology to ebA988 of Azoarcus sp. EbN1 of 43% (gnl|keqq|eba:ebA988(KEGG)). no domains predicted. signal peptie. no TMHs; Conserved hypothetical protein. | 0.608 |
| ilvE2 | azo2776 | azo2775 | azo2776 | Branched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Hypothetical protein, 47% identity to TrEMBL;Q7NW97,TrEMBL;Q7VTV4(56% identity). No domains,repeats, motifs or features present; Function unclear. | 0.802 |
| ilvE2 | mnmA | azo2775 | azo2772 | Branched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | 0.597 |
| ilvE2 | nudJ | azo2775 | azo2774 | Branched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Conserved hypothetical protein; Putative Nudix hydrolase ymfB (EC 3.6.-.-). mutt: mutator mutT protein; Specificity unclear; Belongs to the Nudix hydrolase family. NudJ subfamily. | 0.656 |
| lolB | nudJ | azo0757 | azo2774 | Conserved hypothetical outer membrane lipoprotein; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. | Conserved hypothetical protein; Putative Nudix hydrolase ymfB (EC 3.6.-.-). mutt: mutator mutT protein; Specificity unclear; Belongs to the Nudix hydrolase family. NudJ subfamily. | 0.604 |
| metH | azo0728 | azo3726 | azo0728 | Probable methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Bifunctional DGTP-pyrophosphohydrolase/Thiamine-phosphate diphosphorylase; NUDIX hydrolase/thiamine phosphate synthase Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate (THZ-P) and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity). InterPro: NUDIX hydrolase TIGRFAM: mutt: mutator mutT protein; High confidence in function and specificity. | 0.772 |