STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
azo2784Conserved hypothetical monoamine oxidase. Homology to rsp0431 of R. solanacearum of 34% (trembl|Q8XSN6). In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. InterPro: Amine oxidase (IPR002937). Pfam: Flavin containing amine oxidase. probable signal peptide. no TMH; Family membership. (363 aa)    
Predicted Functional Partners:
azo0839
SWI/SNF family helicase Pfam: Helicase conserved C-terminal domain; Specificity unclear.
    
 0.925
metH
Probable methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
     
  0.871
serA
D-3-phosphoglycerate dehydrogenase, SerA, is involved in the pathway of serine biosynthesis. Similar to sprot|SERA_ECOLI (61%). InterPro (PF00389): D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain InterPro (PF01842): ACT domain InterPro (PF02826): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; High confidence in function and specificity.
    
 0.842
azo1095
Histone deacetylases, acetoin utilization proteins and acetylpolyamine amidohydrolases are all members of an ancient protein superfamily, TREMBL:Q7VZF1 (58% identity); TREMBL:Q7NRU4 (57% identity). InterPro (IPR000286): Histone deacetylase family Pfam (PF00850): Histone deacetylase domain; Family membership.
    
 0.834
azo1601
Histone deacetylases catalyse the removal of the acetyl group from histones. Histone deacetylase, acetoin utilization proteins and acetylpolyamine amidohydrolases are all members of an ancient family, TREMBL:Q7NVL6 (58% identity); TREMBL:Q8XZ00 (57% identity). InterPro (IPR000286): Histone deacetylase superfamily Pfam (PF00850): Histone deacetylase domain; Family membership.
    
 0.834
azo3813
Conserved hypothetical ATP-dependent protease La. Homology to rsc0402 of R. solanacearum of 44% (trembl|Q8Y2D4). N-terminal domain of the ATP-dependent protease La (LON), present also in other bacterial ORFs. InterPro: ATP-dependent protease La (LON) domain (IPR003111). Pfam: ATP-dependent protease La (LON) domain. no signal peptide. no TMHs; Conserved hypothetical protein.
    
  0.759
lepB
LepB protein; Signal peptidase I (EC 3.4.21.89) (SPase I) (Leader peptidase I). SPase I is an integral membrane protein that is anchored in the cytoplasmic membrane by one or two N-terminal transmembrane domains, with the main part of the protein protuding in the periplasmic space. SPase I can cleave N-terminal leader sequences of nonlipoprotein that are exported by the SecYEG pathway or the twin arginine translocation (Tat) pathway. Pfam: Peptidase_S26 probable 2 TMH no signal peptide; High confidence in function and specificity.
     
  0.740
azo3791
Conserved hypothetical ATPase. Homology to MCA0262 of Methylococcus capsulatus of 68% (gi|53756248|gb|AAU90539.1|(NBCI ENTREZ)). InterPro: AAA-protein (ATPases associated with various cellular activities) (IPR003959);AAA ATPase superfamily (IPR003593) Pfam: ATPase family associated with various cellular activities (domaine from 365 aa to 540 aa) no signal peptide. no TMHs; Function unclear.
  
 
  0.718
azo1113
Conserved hypothetical protein. Homology to Bucepa03000705 of Burkholderia cepacia of 33% (gi|46323973|ref|ZP_00224335.1|(NBCI ENTREZ)). No domains predicted. No TMHs. No signal peptide.
  
  
 0.703
azo0443
Beta-lactamase; Conserved Hypothetical protein(Metallo-beta-lactamase superfamily). Has PF00753, Metallo-beta-lactamase superfamily; IPR001279, Blactmase-like;These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor; Family membership.
    
  0.695
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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