Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
azo2785Conserved hypothetical membrane protein. Homology to SC3D11.05C of Streptomyces coelicolor of 33% (trembl|Q9L1F7(SRS)). Pfam (PF00005): ABC transporter. Pfam (PF00664): ABC transporter transmembrane region. TMHMM reporting three transmembrane helices. No signal peptide; Conserved hypothetical protein. (624 aa)    
Predicted Functional Partners:
azo2910
ATP-binding cassette (ABC) transporters form a large family of proteins responsible for translocation of a variety of compounds across biological membranes. They are composed of two transmembrane domains responsible for binding and transport and two nucleotide-binding domains responsible for coupling the energy of ATP hydrolysis to conformational changes in the TMDs, TREMBL:Q8FZX0 (58% identity); TREMBL:Q8U6Y9 (59% identity). InterPro (IPR003593): AAA ATPase. InterPro (IPR001687): ATP/GTP-binding site motif A (P-loop). InterPro (IPR003439): ABC transporter. Pfam (PF00005): ABC transpor [...]
   
 0.816
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.728
azo3351
ATP-binding cassette (ABC) transporters form a large family of proteins responsible for translocation of a variety of compounds across biological membranes. They are composed of two transmembrane domains responsible for binding and transport and two nucleotide-binding domains responsible for coupling the energy of ATP hydrolysis to conformational changes in the TMDs, TREMBL:O59091 (37% identity); TREMBL:Q7NDM5 (40% identity). Pfam (PF00005): ABC transporter. TC (3.A.1): The ATP-binding Cassette (ABC) Superfamily; High confidence in function and specificity.
  
 
 0.718
azo2279
Conserved hypothetical protein. Homology to Avin02000067 of Azotobacter vinelandii of 50% (gi|23105742|ref|ZP_00092196.1|(NBCI ENTREZ)). InterPro: Ankyrin-repeat. The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. Ankyrin repeats are tandemly repeated modules of about 33 amino acids.The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it. The conserved fold of the ankyrin repeat unit is known from several crystal and solution structures [...]
   
 0.716
hscA
Probable chaperone protein; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
  
 
 0.715
ugpB
Glycerol-3-phosphate-binding periplasmic protein precursor. SN-glycerol-3-phosphate and glycerophosphoryl diester-binding protein interacts with the binding protein-dependent transport system ugpACE. 30% SBP_bac_1.IPR006061; SBP_dom1. Pfam:PF01547; SBP_bac_1; 1. Signal peptide:present; High confidence in function and specificity.
  
  
 0.713
azo3626
Conserved hypothetical chaperon protein: Homology to cv2395 of C. violaceum of 62% (trembl|Q7NVE8). InterPro: Heat shock protein hsp70 (IPR001023). Pfam: Hsp70 protein. no signal peptide. no TMHs; Family membership.
  
 
 0.713
azo0646
Toxin secretion ABC transporter permease and ATP-binding protein; HlyB-family protein. Similar to TREMBL:Q7WBM7 (50% identity); TREMBL:Q9KKL9 (41% identity); SWISSPROT:P18770 (28% identity). Pfam (PF00005): ABC transporter. Pfam (PF00664): ABC transporter transmembrane region. TMHMM reporting four transmembrane helices. TC (3.A.1.109.3): LapA adhesin protein exporter, LapB; High confidence in function and specificity.
   
 0.710
azo1316
Putative ATP binding protein; 47% AAA_ATPase.IPR003439; ABC_transporter.IPR008995. Pfam:PF00005; ABC_tran; 1. SMART:SM00382; AAA; 1. non-secretory protein; Function unclear.
  
  
  0.701
atm1
Probable composite transport ATP-binding permease protein. Homology to amt1 of S. cereviciae of 48% (sprot|ATM1_YEAST). COULD BE INVOLVED IN THE TRANSPORT OF yet unknow substrates (probable HEME) FROM THE MITOCHONDRIA TO THE CYTOSOL. InterPro: ABC transporter transmembrane region (IPR001140), ATP/GTP-binding site motif A (P loop) (IPR001687), ABC transporter (IPR003439),AAA_ATPase sperfamily (IPR003593) Pfam: ATP transporter,ABC transporter transmembrane region no signal peptide probable 6 TMHs; Specificity unclear.
    
 0.696
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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