STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ribDAMP deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (363 aa)    
Predicted Functional Partners:
ribAB
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
 0.999
ribE
Riboflavin synthase alpha chain (EC 2.5.1.9). Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1-D)- ribityl-amino-24(1H3H)-pyrimidinedione and L-34-dihydrohy-2- butanone-4-phosphate via 67-dimethyl-8-lumazine. The alpha subunit catalyzes the dismutation of 67-dimethyl-8-lumazine to riboflavin and 5-amino-6-(1-D)-ribityl-amino-24(1H3H)- pyrimidinedione. ribE: riboflavin synthase alpha subunit; High confidence in function and specificity.
 
 0.999
ribH
Riboflavin synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 0.997
ribA
RibA protein; Probable GTP cyclohydrolase II. TIGRFAM: ribA: GTP cyclohydrolase II; Function unclear.
  
 0.970
azo3766
Conserved hypothetical protein. Homology to blr7238 of B.japonicum of 48% (trembl:Q89E49). No domains predicted. No TMHs. Signal peptide with a probability of 0.570.
  
 0.953
ribX
Transcriptional regulator; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family.
  
  
 0.937
accC1
Probable biotin carboxylase (a subunit of acetyl-coa carboxylase); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
   
   0.911
flaG
Probable flagellar protein; Protein flaG. Although these proteins are known to be important for flagellar their exact function is unknown TREMBL:Q82UA2: 56% identity, 79% similarity. InterPro:IPR005186; FlaG. Pfam:PF03646; FlaG L12: ribosomal protein L7/L12 Nonsecretory protein with low signal peptide probability (0.041): SignalP predicted Transmembrane helices 0; High confidence in function and specificity.
   
   0.894
folE
FolE protein; GTP cyclohydrolase I (EC 3.5.4.16) (GTP-CH-I). folE: GTP cyclohydrolase I; High confidence in function and specificity.
    
 0.836
accB
Probable biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
   
   0.816
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.