STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cddDProbable aldehyde dehydrogenase (NAD+). Homology to cddD of R. ruber SC1 of 59% (trembl|Q938F1) Aldehyde dehydrogenases are enzymes which oxidize a wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor. Pfam: Aldehyde dehydrogenase family no TMHs no signal peptide; Family membership. (477 aa)    
Predicted Functional Partners:
acsB
Probable acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
   
 0.935
ackA
Probable acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
    
 0.873
cat1
Probable coenzyme A transferase. Homology to cat1 of C. kluyveri of 51% (sprot|CAT1_CLOKL). Pfam: Acetyl-CoA hydrolase/transferase no signal peptide no TMHs tal_mycobact: transaldolase; Family membership.
    
 0.872
gltB
Ferredoxin-dependent glutamate synthase,; Specificity unclear.
  
 
 0.840
adhA
Putative Alcohol dehydrogenase. Homology to adh-HT of B. stearothermophilus (sprot|ADH3_BACST) THERMOSTABLE AND THERMOPHILIC NAD(+)-DEPENDENT ALCOHOL DEHYDROGENASE. BEARS MAINLY AN ETHANOL-DEHYDROGENASE ACTIVITY. CATALYTIC ACTIVITY:An alcohol + NAD(+) = an aldehyde or ketone + NADH. COFACTOR: Binds 2 zinc ions per subunit (By similarity). Pfam: Zinc-binding dehydrogenase Tirgfam: tdh: L-threonine 3-dehydrogenase no signal peptide no TMHs; Family membership.
  
 0.796
yhdH
TREMBL:Q881C6:69% identity; 83% similarity. Alcohol dehydrogenase (EC: 1.1.1.1) (ADH) catalyzes the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD: Ethanol + NAD = Acetaldehyde + NADH Protein yhdH. InterPro:IPR002085; Adh_zn_family. Pfam:PF00107; ADH_zinc_N; FAD binding domain InterPro: Zinc-containing alcohol dehydrogenase superfamily TIGRFAM:tdh: L-threonine 3-dehydrogenase; High confidence in function and specificity.
    
 0.796
gltD
Glutamate synthase (small chain) oxidoreductase; Glutamate synthase [NADPH] precursor (EC 1.4.1.13) (NADPH-GOGAT)small chain. TREMBL:Q8XV67-77% identity, 87% similarity InterPro:IPR006005- One pathway for the assimilation of ammonia and glutamate biosynthesis involves glutamate synthase (EC: 1.4.1.13) which transfers the amide group of glutamine to 2-oxoglutarate to yield two molecules of glutamate. 2 L-glutamate + NADP+ = L-glutamine + 2-oxoglutarate + NADPH + H+ gid: gid protein Pfam:FAD binding domain,Thi family, 4Fe-4S binding domain,KTN-NAD binding domain, DUF127; High confidence [...]
    
 0.742
ansB2
Periplasmic L-asparaginase II; L-asparaginase precursor (EC 3.5.1.1) (L-asparagine amidohydrolase) (L-ASNase); High confidence in function and specificity; Belongs to the asparaginase 1 family.
     
 0.727
putA
Probable bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.
  
 0.700
adhC
Alcohol dehydrogenase class III (Formaldehyde dehydrogenase (glutathione)). Homology to fdh of E. coli of 72% (trembl|Q59399) CLASS-III ADH IS REMARKABLY INEFFECTIVE IN OXIDIZING ETHANOL BUT IT READILY CATALYZES THE OXIDATION OF LONG-CHAIN PRIMARY ALOCHOLS AND THE OXIDATION OF S-(HYDROXYMETHYL) GLUTATHIONE (BY SIMILARITY). InterPro: Zinc-containing alcohol dehydrogenase superfamily (IPR002085) Zinc-containing alcohol dehydrogenase (IPR002328) Pfam: zinc-binding dehydrogenase Tigrfam: tdh: L-threonine 3-dehydrogenase. no signal peptide. 2 TMHs; High confidence in function and specificity.
  
 0.652
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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