STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo2860Conserved hypothetical membrane protein. Homology to PJS6w01004232 of Polaromonas sp. JS666 of 53% (gi|54028976|ref|ZP_00361120.1|(NBCI ENTREZ)). InterPro:IPR002035; VWF_A. The von Willebrand factor is a large multimeric glycoprotein found in blood plasma. Mutant forms are involved in the aetiology of bleeding disorders. In von Willebrand factor, the type A domain (vWF) is the prototype for a protein superfamily. Pfam:PF00092; VWA; 1. SMART:SM00327; VWA; 1. PROSITE:PS50234; VWFA; MIP: MIP family channel proteins. No signal peptide present. No. of TMH's: 3 (TMHMM predicted); Conserved h [...] (343 aa)    
Predicted Functional Partners:
azo2861
Hypothetical protein Rv1480/MT1527/Mb1516. TREMBL:Q7MUE8: 33% identity, 52% similarity. This domain is found in a family of prokaryotic proteins that have no known function. Proteins belonging to this family include hypothetical proteins from eubacteria and archaebacteria. Some of these proteins also contain the Von Willebrand factor, type A domain InterPro: IPR002881; DUF58. Pfam: PF01882; DUF58 Absence of transmembrane helices (TMHMM predicted) cmk: cytidylate kinase; Specificity unclear.
 
  
 0.956
moxR2
MoxR protein, putative; MoxR protein (MxaR protein). MAY BE INVOLVED IN THE REGULATION OF FORMATION OF ACTIVE METHANOL DEHYDROGENASE. TREMBLnew:CAE55395: 54% identity, 71% similarity InterPro:IPR003593; AAA_ATPase. IPR000523; Mg_chelatse_chII. Pfam PF01078; Mg_chelatase; 1. SMART SM00382; AAA; 1 InterPro IPR003593; AAA_ATPas ruvB: Holliday junction DNA helicase Ru; High confidence in function and specificity.
 
  
 0.945
azo2630
Cobalamin biosynthesis protein, putative; CobN Magnesium Chelatase family protein, by similarity; Family membership.
 
 
 0.730
azo2863
Conserved hypothetical serine protease. Homology to PJS6w01004229 of Polaromonas sp. JS666 of 53% (gi|54028973|ref|ZP_00361117.1|(NBCI ENTREZ)). Interpro: HtrA/DegQ protease family (IPR001940); Serine protease,trypsine family (IPR001254). Pfam: Typsin. probable signal peptide. no TMHs; Conserved hypothetical protein.
 
   
 0.726
inaA
Conserved hypothetical InaA protein. Homology to inaA of P. putida of 39% (gnl|keqq|ppu:PP0904(KEGG)). Pfam: Lipopolysaccharide kinase (Kdo/WaaP) family. These lipopolysaccharide kinases are related to protein kinases Pkinase. This family includes waaP (rfaP) gene product is required for the addition of phosphate to O-4 of the first heptose residue of the lipopolysaccharide (LPS) inner core region. It has previously been shown that WaaP is necessary for resistance to hydrophobic and polycationic antimicrobials in E. coli and that it is required for virulence in invasive strains of S. e [...]
   
  0.570
waaP3
Lipopolysaccharide core biosynthesis protein. INVOLVED IN ATTACHMENT OF PHOSPHATE-CONTAINING SUBSTITUENTS TO THE INNER CORE. Specific function unclear.
   
  0.570
azo3571
Conserved hypothetical protein; InterPro: Eukaryotic protein kinase. Might be related to lipopolysaccharide biosynthesis, due to the presence of the gene in a lipopolysaccharide gene cluster.
   
  0.570
azo3573
Conserved hypothetical protein, 43% identity(65% similarity) to TrEMBL|Q9HUG7,Hypothetical protein PA4998 [PA4998] [Pseudomonas aeruginosa]. Has PF06293:IPR010440:Lipopolysaccharide kinase (Kdo/WaaP) family;These lipopolysaccharide kinases are related to protein kinases Pkinase. This family includes waaP (rfaP) gene product is required for the addition of phosphate to O-4 of the first heptose residue of the lipopolysaccharide (LPS) inner core region. It has previously been shown that WaaP is necessary for resistance to hydrophobic and polycationic antimicrobials in E. coli and that it [...]
   
  0.570
moxR1
MoxR protein (MxaR protein). MAY BE INVOLVED IN THE REGULATION OF FORMATION OF ACTIVE METHANOL DEHYDROGENASE. TREMBL:Q883V0: 60% identity, 73% similarity SMART: SM00382; AAA InterPro: IPR003593; AAA_ATPase. IPR001270; Chaprnin_clpA/B. IPR003442; UPF0079. Pfam: PF02367; UPF0079; Pfam: Mg_chelatase:Magnesium chelatase, subunit ChlI ruvB: Holliday junction DNA helicase Ru No signal peptide and transmembrane helices; High confidence in function and specificity.
 
  
 0.534
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
    
 0.525
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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