Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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[Homology]
Score
azo2867Transcriptional regulator, LysR family This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression. 44% 1 helixturnhelix PF03466 LysR_substrate; 1. HTH reporting nucleic acid binding motif; Specificity unclear. (313 aa)    
Predicted Functional Partners:
gltR
Probable transcriptional regulator, LysR family; HTH-type transcriptional regulator gltR. POSITIVE REGULATOR OF GLUTAMATE BIOSYNTHESIS (GLTAB GENES). NEGATIVELY REGULATES ITS OWN EXPRESSION. Similar to SWISSPROT: sprot|GLTR_BACSU (33% Bacillus subtilis, HTH-type transcriptional regulator GltR) InterPro: IPR000847 HTH_LysR. IPR009058 Winged helix DNA-binding. Pfam: PF00126 Bacterial regulatory helix-turn-helix protein,lysR family. HTH reporting nucleic acid binding motif; High confidence in function and specificity.
  
     0.695
azo3003
Conserved hypothetical transcriptional regulator,LysR family. Similar to SWISSPROT: sprot|NTCB_SYNP7 (18% Synechococcus sp. (strain PCC 7942) (Anacystis nidulans R2), nitrogen assimilation transcriptional activator NtcB) Pfam: PF00126 Bacterial regulatory helix-turn-helix protein, lysR family. HTH reporting nucleic acid binding motif; Family membership.
  
     0.682
cbl-2
HTH-type transcriptional regulator cbl (Cys regulon transcriptional activator) Belongs to the LysR family of transcriptional regulators. THIS PROTEIN IS A POSITIVE REGULATOR OF GENE EXPRESSION FOR THE CYSTEINE REGULON. THE INDUCER FOR CYSB IS N-ACETYLSERINE (BY SIMILARITY). ribD_Cterm: riboflavin-specific deami 42% similarity to the HTH-type transcriptional regulator cbl, E. coli SWISSPROT:CBL_ECOLI IPR000847; HTH_LysR. IPR005119; LysR_subst. PF00126; HTH_1; 1. helix-turn-helix PF03466; LysR_substrate; 1. HTH reporting nucleic acid binding motif; High confidence in function and specificity.
  
     0.549
ygiD
Protocatechuate 4,5-dioxygenase; Putative cytoplasmic protein ygiD, 35% identity to TrEMBL;Q8ZLZ3. TrEMBL;Q8XBP3,Q83JK6. Has PF02900,Catalytic LigB subunit of aromatic ring-opening dioxygenase;IPR004183:The LigAB enzyme (a protocatechuate 4,5-dioxygenase), of Sphingomonas paucimobilis oxidizes protocatechuate (or 3,4-dihydroxybenzoic acid, PCA). The enzyme belongs to the class III extradiol-type catecholic dioxygenase family, which catalyzes the ring-opening reaction of protocatechuate and related compounds; Conserved hypothetical protein.
       0.544
oxyR
oxyR, Hydrogen peroxide-inducible genes activator. BELONGS TO THE LYSR FAMILY OF TRANSCRIPTIONAL REGULATORS REQUIRED FOR THE INDUCTION OF A REGULON OF HYDROGEN PEROXIDE INDUCIBLE GENES SUCH AS CATALASE GLUTATHIONE-REDUCTASE ETC. (BY SIMILARITY). mreB: cell shape determining protein M 51% HTH_LysR. IPR005119; LysR_subst. IPR009058; Wing_hlx_DNA_bnd. PF00126; HTH_1; 1. PF03466; LysR_substrate; 1. HTH reporting nucleic acid binding motif; High confidence in function and specificity.
  
     0.513
azo2869
Conserved hypothetical cytochrome B561. Homology to cv3278 of C. violaceum of 69% (trembl|Q7NSZ1). Involved in electronen transport. no domains reported. no signal peptide. 4 TMHs; Family membership.
       0.509
rpoZ
DNA-directed RNA polymerase; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
  
 
 
 0.504
rpoA
DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
   0.462
rpoB
DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.423
azo2870
Conserved hypothetical YceI like protein. Homology to CV3277 of C.violaceum of 51% (tremble:Q7NSZ2). Has PF04264, YceI like family;(IPR007372): E. coli YceI is a base-induced periplasmic protein. Its function has not yet been characterised. Signal peptide present. No TMH present; Conserved hypothetical protein; Belongs to the UPF0312 family.
       0.422
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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