STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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[Homology]
Score
azo2867Transcriptional regulator, LysR family This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression. 44% 1 helixturnhelix PF03466 LysR_substrate; 1. HTH reporting nucleic acid binding motif; Specificity unclear. (313 aa)    
Predicted Functional Partners:
gltR
Probable transcriptional regulator, LysR family; HTH-type transcriptional regulator gltR. POSITIVE REGULATOR OF GLUTAMATE BIOSYNTHESIS (GLTAB GENES). NEGATIVELY REGULATES ITS OWN EXPRESSION. Similar to SWISSPROT: sprot|GLTR_BACSU (33% Bacillus subtilis, HTH-type transcriptional regulator GltR) InterPro: IPR000847 HTH_LysR. IPR009058 Winged helix DNA-binding. Pfam: PF00126 Bacterial regulatory helix-turn-helix protein,lysR family. HTH reporting nucleic acid binding motif; High confidence in function and specificity.
  
     0.695
azo3003
Conserved hypothetical transcriptional regulator,LysR family. Similar to SWISSPROT: sprot|NTCB_SYNP7 (18% Synechococcus sp. (strain PCC 7942) (Anacystis nidulans R2), nitrogen assimilation transcriptional activator NtcB) Pfam: PF00126 Bacterial regulatory helix-turn-helix protein, lysR family. HTH reporting nucleic acid binding motif; Family membership.
  
     0.682
cbl-2
HTH-type transcriptional regulator cbl (Cys regulon transcriptional activator) Belongs to the LysR family of transcriptional regulators. THIS PROTEIN IS A POSITIVE REGULATOR OF GENE EXPRESSION FOR THE CYSTEINE REGULON. THE INDUCER FOR CYSB IS N-ACETYLSERINE (BY SIMILARITY). ribD_Cterm: riboflavin-specific deami 42% similarity to the HTH-type transcriptional regulator cbl, E. coli SWISSPROT:CBL_ECOLI IPR000847; HTH_LysR. IPR005119; LysR_subst. PF00126; HTH_1; 1. helix-turn-helix PF03466; LysR_substrate; 1. HTH reporting nucleic acid binding motif; High confidence in function and specificity.
  
     0.549
ygiD
Protocatechuate 4,5-dioxygenase; Putative cytoplasmic protein ygiD, 35% identity to TrEMBL;Q8ZLZ3. TrEMBL;Q8XBP3,Q83JK6. Has PF02900,Catalytic LigB subunit of aromatic ring-opening dioxygenase;IPR004183:The LigAB enzyme (a protocatechuate 4,5-dioxygenase), of Sphingomonas paucimobilis oxidizes protocatechuate (or 3,4-dihydroxybenzoic acid, PCA). The enzyme belongs to the class III extradiol-type catecholic dioxygenase family, which catalyzes the ring-opening reaction of protocatechuate and related compounds; Conserved hypothetical protein.
       0.545
oxyR
oxyR, Hydrogen peroxide-inducible genes activator. BELONGS TO THE LYSR FAMILY OF TRANSCRIPTIONAL REGULATORS REQUIRED FOR THE INDUCTION OF A REGULON OF HYDROGEN PEROXIDE INDUCIBLE GENES SUCH AS CATALASE GLUTATHIONE-REDUCTASE ETC. (BY SIMILARITY). mreB: cell shape determining protein M 51% HTH_LysR. IPR005119; LysR_subst. IPR009058; Wing_hlx_DNA_bnd. PF00126; HTH_1; 1. PF03466; LysR_substrate; 1. HTH reporting nucleic acid binding motif; High confidence in function and specificity.
  
     0.513
azo2869
Conserved hypothetical cytochrome B561. Homology to cv3278 of C. violaceum of 69% (trembl|Q7NSZ1). Involved in electronen transport. no domains reported. no signal peptide. 4 TMHs; Family membership.
       0.509
azo2870
Conserved hypothetical YceI like protein. Homology to CV3277 of C.violaceum of 51% (tremble:Q7NSZ2). Has PF04264, YceI like family;(IPR007372): E. coli YceI is a base-induced periplasmic protein. Its function has not yet been characterised. Signal peptide present. No TMH present; Conserved hypothetical protein; Belongs to the UPF0312 family.
       0.422
hupR
Transcriptional regulator, LysR family,; Family membership; Belongs to the LysR transcriptional regulatory family.
  
     0.421
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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