| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aroA | azo2926 | azo1071 | azo2926 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. | Conserved hypothetical secreted protein. Homology to orf of P.aeruginosa of 30% (ZP_00137401). No domains predicted. Signal peptide reported present. No TMH reported present; Conserved hypothetical protein. | 0.507 |
| aroA | guaA | azo1071 | azo1581 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.667 |
| aroA | guaB | azo1071 | azo1580 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.642 |
| aroA | pyrF | azo1071 | azo3659 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. | Orotidine-5'-phosphate decarboxylase (Orotidylic decarboxylase) (OMP decarboxylase) (OMPdcase) (Uridine 5'-monophosphate synthase) (UMP synthase); High confidence in function and specificity; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.757 |
| aroA | thyA | azo1071 | azo3197 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.567 |
| azo1998 | azo2926 | azo1998 | azo2926 | Purine-nucleoside phosphorylase; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. | Conserved hypothetical secreted protein. Homology to orf of P.aeruginosa of 30% (ZP_00137401). No domains predicted. Signal peptide reported present. No TMH reported present; Conserved hypothetical protein. | 0.488 |
| azo1998 | guaA | azo1998 | azo1581 | Purine-nucleoside phosphorylase; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.671 |
| azo1998 | guaB | azo1998 | azo1580 | Purine-nucleoside phosphorylase; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.503 |
| azo2925 | azo2926 | azo2925 | azo2926 | Hypothetical secredted protein. no homology of the entire protein to the data bank. no domains predicted signal peptide no TMHs. | Conserved hypothetical secreted protein. Homology to orf of P.aeruginosa of 30% (ZP_00137401). No domains predicted. Signal peptide reported present. No TMH reported present; Conserved hypothetical protein. | 0.848 |
| azo2925 | tupB | azo2925 | azo2924 | Hypothetical secredted protein. no homology of the entire protein to the data bank. no domains predicted signal peptide no TMHs. | Probable tungstate permease protein. Homology to tupB of E. acidaminophilum of 40% (tremble: Q93KD5) Permase of an abc-transport system involved in transport of oxyanions. no signal peptide probable 5 TMHs; Family membership. | 0.527 |
| azo2926 | aroA | azo2926 | azo1071 | Conserved hypothetical secreted protein. Homology to orf of P.aeruginosa of 30% (ZP_00137401). No domains predicted. Signal peptide reported present. No TMH reported present; Conserved hypothetical protein. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. | 0.507 |
| azo2926 | azo1998 | azo2926 | azo1998 | Conserved hypothetical secreted protein. Homology to orf of P.aeruginosa of 30% (ZP_00137401). No domains predicted. Signal peptide reported present. No TMH reported present; Conserved hypothetical protein. | Purine-nucleoside phosphorylase; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. | 0.488 |
| azo2926 | azo2925 | azo2926 | azo2925 | Conserved hypothetical secreted protein. Homology to orf of P.aeruginosa of 30% (ZP_00137401). No domains predicted. Signal peptide reported present. No TMH reported present; Conserved hypothetical protein. | Hypothetical secredted protein. no homology of the entire protein to the data bank. no domains predicted signal peptide no TMHs. | 0.848 |
| azo2926 | azo3964 | azo2926 | azo3964 | Conserved hypothetical secreted protein. Homology to orf of P.aeruginosa of 30% (ZP_00137401). No domains predicted. Signal peptide reported present. No TMH reported present; Conserved hypothetical protein. | Conserved Hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.532 |
| azo2926 | guaA | azo2926 | azo1581 | Conserved hypothetical secreted protein. Homology to orf of P.aeruginosa of 30% (ZP_00137401). No domains predicted. Signal peptide reported present. No TMH reported present; Conserved hypothetical protein. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.713 |
| azo2926 | guaB | azo2926 | azo1580 | Conserved hypothetical secreted protein. Homology to orf of P.aeruginosa of 30% (ZP_00137401). No domains predicted. Signal peptide reported present. No TMH reported present; Conserved hypothetical protein. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.537 |
| azo2926 | purB | azo2926 | azo0901 | Conserved hypothetical secreted protein. Homology to orf of P.aeruginosa of 30% (ZP_00137401). No domains predicted. Signal peptide reported present. No TMH reported present; Conserved hypothetical protein. | Adenylosuccinate lyase (Adenylosuccinase) (ASL); High confidence in function and specificity; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.499 |
| azo2926 | pyrF | azo2926 | azo3659 | Conserved hypothetical secreted protein. Homology to orf of P.aeruginosa of 30% (ZP_00137401). No domains predicted. Signal peptide reported present. No TMH reported present; Conserved hypothetical protein. | Orotidine-5'-phosphate decarboxylase (Orotidylic decarboxylase) (OMP decarboxylase) (OMPdcase) (Uridine 5'-monophosphate synthase) (UMP synthase); High confidence in function and specificity; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.518 |
| azo2926 | thyA | azo2926 | azo3197 | Conserved hypothetical secreted protein. Homology to orf of P.aeruginosa of 30% (ZP_00137401). No domains predicted. Signal peptide reported present. No TMH reported present; Conserved hypothetical protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.505 |
| azo2926 | tupB | azo2926 | azo2924 | Conserved hypothetical secreted protein. Homology to orf of P.aeruginosa of 30% (ZP_00137401). No domains predicted. Signal peptide reported present. No TMH reported present; Conserved hypothetical protein. | Probable tungstate permease protein. Homology to tupB of E. acidaminophilum of 40% (tremble: Q93KD5) Permase of an abc-transport system involved in transport of oxyanions. no signal peptide probable 5 TMHs; Family membership. | 0.571 |