STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo2948Putative hydrolase; AAH:63279: 42% identity, 55% similarity Anti-oncogene; SH3 domain; Repeat; Description:SAM and SH3 domains containing protein 1 (proline-glutamate repeat-containing protein). Gene name(s) sash1 or pepe1 contains 1 SH3 domain. similarity: contains 2 sterile alpha motif (SAM) domains May have a role in a signaling pathway. Could act as a tumor supressor. InterPro: IPR001660; SAM. IPR001452: SH3. Pfam:PF00536; SAM; 2. PF00018:SH3; 1. SMART:SM00454; SAM; Function unclear. (97 aa)    
Predicted Functional Partners:
czcC
Putative outer membrane efflux protein involved in cobalt-zinc-cadmium resistance (Cation efflux system protein czcC). Homology to czcC of R. eutropha of 24%. czcC protein appears to modify the specificity of the system perhaps by acting on the czcB protein. When the czcC protein is added to czcA and czcB the efflux systems gained specificity for Cd(2+)and Co(2+) signal peptide no TMHs; Family membership.
       0.773
azo2950
Multicopper oxidases are enzymes that possess three spectroscopically differentcopper centers. Similar to TREMBL:Q7X4G1 (71% identity); TREMBL:Q8U8U7 (71% identity); TREMBL:Q92ZC7 (70% identity). InterPro (IPR001117): Multicopper oxidase type 1. Pfam (PF00394): Multicopper oxidase. SignalP reporting signal peptide; Function unclear.
       0.705
azo2947
Conserved hypothetical secreted protein. Homology to pp5391 of P. putida of 31% (trembl|Q88BZ2). no domains predicted. signal peptide. no TMHs; Conserved hypothetical protein.
       0.588
azo2951
CopC: copper tolerance protein.CopC is a bacterial blue copper protein that binds 1 atom of copper per protein molecule. Along with CopA, CopC mediates copper resistance by sequestration of copper in the periplasm. 43% Cu-oxidase. InterPro:IPR008972; Cupredoxin. Signal pepetide:present. TMhelix:1; Function unclear.
       0.517
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.