STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo2951CopC: copper tolerance protein.CopC is a bacterial blue copper protein that binds 1 atom of copper per protein molecule. Along with CopA, CopC mediates copper resistance by sequestration of copper in the periplasm. 43% Cu-oxidase. InterPro:IPR008972; Cupredoxin. Signal pepetide:present. TMhelix:1; Function unclear. (166 aa)    
Predicted Functional Partners:
azo2950
Multicopper oxidases are enzymes that possess three spectroscopically differentcopper centers. Similar to TREMBL:Q7X4G1 (71% identity); TREMBL:Q8U8U7 (71% identity); TREMBL:Q92ZC7 (70% identity). InterPro (IPR001117): Multicopper oxidase type 1. Pfam (PF00394): Multicopper oxidase. SignalP reporting signal peptide; Function unclear.
 
 
 0.983
czcC
Putative outer membrane efflux protein involved in cobalt-zinc-cadmium resistance (Cation efflux system protein czcC). Homology to czcC of R. eutropha of 24%. czcC protein appears to modify the specificity of the system perhaps by acting on the czcB protein. When the czcC protein is added to czcA and czcB the efflux systems gained specificity for Cd(2+)and Co(2+) signal peptide no TMHs; Family membership.
 
     0.889
azo2952
Conserved hypothetical secreted protein. Homology to SMc02284 of S. meliloti of 38% (trembl|Q92S41(SRS)). Has PF07076:IPR009780;Protein of unknown function (DUF1344):This family consists of several short,hypothetical bacterial proteins of around 80 residues in length. Members of this family are found in Rhizobium,Agrobacterium and Brucella species. The function of this family is unknown. Signal peptide predicted. No TMHs; Conserved hypothetical protein.
 
     0.888
azo2956
Similar to E.coli CopA: copper transporting P-type ATPase protein, involved in the uptake and metabolism of copper(EC 3.6.3.4).Involved in copper transport(By similarity). Putative cation transporting P-type ATPase (EC 3.6.3.-); High confidence in function and specificity.
 
   
 0.686
cusB
Cation efflux transmembrane protein; Putative membrane fusion protein silB precursor. COMPONENT OF THE SIL CATION-EFFLUX SYSTEM THAT CONFERS RESISTANCE TO SILVER. MAY BE PART OF A THREE-COMPONENT CATION/PROTON ANTIPORTER; High confidence in function and specificity.
 
     0.621
gch
Probable GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
     
 0.610
azo1916
Conserved hypothetical secreted protein. Homology to blr1303 of B. japonicum of 38% (trembl|Q89UV6(SRS)) No domains predicted. Signal peptide present. No TMH present; Conserved hypothetical protein.
  
     0.609
azo2944
Conserved hypothetical secreted protein. Homology to ws0556 of W. succinogenes of 51% (trembl|Q7MSD6). Pfam: DUF411. The function of the members of this bacterial protein family is unknown. Some members may be involved in conferring cation resistance. signal peptide. TMH in signal peptide; Conserved hypothetical protein.
 
  
 0.588
azo2948
Putative hydrolase; AAH:63279: 42% identity, 55% similarity Anti-oncogene; SH3 domain; Repeat; Description:SAM and SH3 domains containing protein 1 (proline-glutamate repeat-containing protein). Gene name(s) sash1 or pepe1 contains 1 SH3 domain. similarity: contains 2 sterile alpha motif (SAM) domains May have a role in a signaling pathway. Could act as a tumor supressor. InterPro: IPR001660; SAM. IPR001452: SH3. Pfam:PF00536; SAM; 2. PF00018:SH3; 1. SMART:SM00454; SAM; Function unclear.
       0.517
azo2955
Putative cation efflux system protein; Region start changed from 3242195 to 3242423 (-228 bases); Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
   
 0.469
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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