STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
azo2952Conserved hypothetical secreted protein. Homology to SMc02284 of S. meliloti of 38% (trembl|Q92S41(SRS)). Has PF07076:IPR009780;Protein of unknown function (DUF1344):This family consists of several short,hypothetical bacterial proteins of around 80 residues in length. Members of this family are found in Rhizobium,Agrobacterium and Brucella species. The function of this family is unknown. Signal peptide predicted. No TMHs; Conserved hypothetical protein. (113 aa)    
Predicted Functional Partners:
czcC
Putative outer membrane efflux protein involved in cobalt-zinc-cadmium resistance (Cation efflux system protein czcC). Homology to czcC of R. eutropha of 24%. czcC protein appears to modify the specificity of the system perhaps by acting on the czcB protein. When the czcC protein is added to czcA and czcB the efflux systems gained specificity for Cd(2+)and Co(2+) signal peptide no TMHs; Family membership.
 
 
 0.890
azo2951
CopC: copper tolerance protein.CopC is a bacterial blue copper protein that binds 1 atom of copper per protein molecule. Along with CopA, CopC mediates copper resistance by sequestration of copper in the periplasm. 43% Cu-oxidase. InterPro:IPR008972; Cupredoxin. Signal pepetide:present. TMhelix:1; Function unclear.
 
     0.888
azo2950
Multicopper oxidases are enzymes that possess three spectroscopically differentcopper centers. Similar to TREMBL:Q7X4G1 (71% identity); TREMBL:Q8U8U7 (71% identity); TREMBL:Q92ZC7 (70% identity). InterPro (IPR001117): Multicopper oxidase type 1. Pfam (PF00394): Multicopper oxidase. SignalP reporting signal peptide; Function unclear.
 
   
 0.887
azo2955
Putative cation efflux system protein; Region start changed from 3242195 to 3242423 (-228 bases); Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
  
 0.771
cusB
Cation efflux transmembrane protein; Putative membrane fusion protein silB precursor. COMPONENT OF THE SIL CATION-EFFLUX SYSTEM THAT CONFERS RESISTANCE TO SILVER. MAY BE PART OF A THREE-COMPONENT CATION/PROTON ANTIPORTER; High confidence in function and specificity.
 
 0.763
azo2953
Conserved hypothetical outer membrane efflux. Homology to ebA2169 Azoarcus sp. EbN1 of 68% (gnl|keqq|eba:ebA2169(KEGG)). Pfam: Outer membrane efflux protein. signal peptide. probable 1 TMH in signal peptide; Conserved hypothetical protein.
 
 
 0.638
azo1086
Putative MerR-family transcriptional regulator,similar toTREMBL: trembl|Q83C17 (51% Coxiella burnetii,cbu1319) Pfam: PF00376 MerR family regulatory protein. HTH reporting nucleic acid binding motif.
   
  
 0.608
bfr3
Bacterioferritin (BFR) (Cytochrome B-1) (Cytochrome B-557). In E. coli is an iron-storage protein consisting of 24 identical subunits that pack together to form a highly symmetrical, nearly spherical shell surrounding a central cavity of about 8 nm diameter.X-ray crystallographic studies have revealed a close structural similarity between BFR and the ferritins, a family of iron-storage proteins found in both eukaryota and prokaryota. Key role in iron homeostasis.InterPro: Bacterioferritin. Non-secretory protein bfr: bacterioferritin; High confidence in function and specificity.
   
    0.576
czcA1
Cobalt-zinc-cadmium resistance protein CzcA (cation efflux system protein CzcA). In A.eutrophus has a low cation transport activity for cobalt, it is essential for the expression of cobalt, zinc, and cadmium resistance.Czca and Czcb together would act in zinc efflux nearly as effectively as the complete czc efflux system (czcABC).Belongs to the acrb/acrd/acrf family. 41% similarity to the A.eutrophus CzcA protein. SWISSPROT:CZCA_ALCEU:P13511 InterPro: Heavy metal efflux pump CzcA. InterPro:IPR001036; Acrflvin_res.IPR004763: CzcA. Pfam:PF00873; ACR_tran; 1. InterPro:TIGR00914:Heavy meta [...]
  
  
 0.542
czcA2
Cobalt-zinc-cadmium resistance protein CzcA (cation efflux system protein CzcA). In A.eutrophus has a low cation transport activity for cobalt, it is essential for the expression of cobalt, zinc, and cadmium resistance.Czca and Czcb together would act in zinc efflux nearly as effectively as the complete czc efflux system (czcABC).Belongs to the acrb/acrd/acrf family. 41% similarity to the A.eutrophus CzcA protein. SWISSPROT:CZCA_ALCEU:P13511 InterPro: Heavy metal efflux pump CzcA. InterPro:IPR001036; Acrflvin_res.IPR004763: CzcA. Pfam:PF00873; ACR_tran; 1. InterPro:TIGR00914:Heavy meta [...]
  
  
 0.542
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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