STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo2973Pentapeptide repeat family protein, 36% identity(46% similarity) to TrEMBL;Q88JH6. Signal P reporting Signal Peptide present. Has 3 copies of PF00805,Pentapeptide repeats;IPR001646, 5peptide_repeat;These repeats are found in many cyanobacterial proteins. The repeats were first identified in hglK The function of these repeats is unknown. The structure of this repeat has been predicted to be a beta-helix. The repeat can be approximately described as A(D/N)LXX, where X can be any amino acid; Conserved hypothetical protein. (186 aa)    
Predicted Functional Partners:
exaB2
Putative cytochrome c550. Homology to exaB of P. aeruginosa of 37% (trembl|Q9Z4P8). Cytochrome c550 is an essential component of the quinoprotein ethanol oxidation. InterPro: Cytochrome c class I (IPR003088) Pfam: cytochrome c signal peptide no TMHs; Function unclear.
 
    0.903
gyrB
DNA topoisomerase (ATP-hydrolysing); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent [...]
   
 
 0.849
parE
Topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.
   
 
 0.849
azo2060
Membrane-bound lytic murein transglycosylase D; Region start changed from 2259236 to 2259431 (-195 bases).
   
 
 0.842
exaA2
Quinoprotein ethanol dehydrogenase precursor (QEDH). Oxidizes primary alcohols and also acts on secondary alcohol, but not highly active on methanol. 73% Bac_PQQ.IPR002372; Bac_PQQ_repeat. Pfam:PF01011; PQQ; 2. Signal peptide:present; High confidence in function and specificity.
 
  
 0.707
azo0628
Putative adenylate/guanylate cyclase,; Conserved hypothetical protein.
  
  
  0.694
azo2450
Putative two-component system sensor protein,; Function unclear.
 
 
 0.669
azo1490
Conserved hypothetical signaling protein. Homology to ebA6472 Azoarcus sp. EbN1 of 36% (gnl|keqq|eba:ebA6472(KEGG)). InterPro: IPR000160 GGDEF. IPR000014 PAS. IPR000700 PAS-assoc_C. IPR001789 Response_reg. Pfam: PF00990 GGDEF domain. PF00989 PAS domain. PF00785 PAC motif. PF01590 GAF domain. PF00563 EAL domain. PF00072 Response_reg. TIGRFAM:TIGR00229 PAS domain S-box. TIGR00254 putative diguanylate cyclase (GGDEF) domain. No signal peptide. No TMHs; Conserved hypothetical protein.
   
 0.617
azo1256
Putative serin/threonine protein kinase, only very low similarity to SWISSPROT: sprot|PKSC_STRCO (13% Streptomyces coelicolor, serine/threonine protein kinase PksC (EC 2.7.11.1)) / TREMBL: trembl|Q9S478 (13% Myxococcus xanthus, Pkn4). Pfam: PF00069 Pkinase. SMART:SM00221 STYKc (Protein kinase; unclassified specificity). SM00065 GAF (Domain present in phytochromes and cGMP-specific phosphodiesterases); Family membership.
    
 0.611
pykA
Pyruvate kinase (PK) catalyses the final step in glycolysis, the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP:ADP + phosphoenolpyruvate = ATP + pyruvate. 52% Pyruvate_kinase. Pfam:PF00224; PK; 1.PF02887; PK_C; 1. TIGRFAMs:TIGR01064; pyruv_kin; 1; High confidence in function and specificity.
    
 0.607
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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