STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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[Homology]
Score
fhuFPutative TonB-dependent receptor; Ferrioxamine B receptor precursor, FhuF. Iron-regulated outer membrane protein that bind and uptake ferrioxamine in association with the TonB protein. Involved in the reduction of ferric iron in cytoplasmic ferrioxamine B. Binds 1 2Fe-2S cluster. In e.coli the fhuF gene reacts very sensitive to minor changes of Fe2+ and Fur(Ferric uptake regulator). SWISSPROT: FOXA_SALTY. Prim. accession #:Q56145 EMBL: AE008712; AAL19318.1; AF060876; AAC15464.1; U62282; AAB04552.1; InterPro:IPR000531; TonB_boxC. Pfam: PF00593; TonB_dep_Rec; 1. PROSITE: PS00430; TONB_DE [...] (715 aa)    
Predicted Functional Partners:
azo2996
Conserved hypothetical membrane protein. Homology to PA2403 of Pseudomonas aeruginosa of 38% (trembl|Q8G8F6). Has 3 copies of PF03929, PepSY-associated TM helix;IPR005625 pEPsy_tm; This domain represents a conserved TM helix found in bacterial proteins. Has PF03413, Peptidase propeptide and YPEB domain; IPR005075,Propep_PepSY:This region is likely to have an protease inhibitory function (personal obs:C Yeats). This region is likely to have an protease inhibitory function (personal obs:C Yeats). This model is likely to miss some members of this family as the separation from signal to no [...]
 
   
 0.868
azo2995
Conserved hypothetical membrane protein. Homology to IL2513 of Idiomarina loihiensis of 37% (gnl|keqq|ilo:IL2513(KEGG)). no domains predicted. no signal peptide. 1 TMH; Conserved hypothetical protein.
       0.773
azo0235
Conserved hypothetical membrane protein. Homology to an orf of Rubrivivax gelatinosus of 55% (gi|47575633|ref|ZP_00245668.1|(NBCI ENTREZ)). No domains predicted. No signal peptide. 1 TMHs; Conserved hypothetical protein.
  
 
 0.692
tolA
Conserved hypothetical membrane protein. Homology to tolA of N. europaea of 39% (trembl|Q82XP0). no domains predicted InterPro: Proline-rich region (IPR000694) no signal peptide 1 TMHs; Conserved hypothetical protein.
  
 
 0.692
tonB1
Putative TonB protein. Homology to tonb2 of P. aeruginosa of 39% (TREMBL:Q9RMT3). To complete transport of bound iron across the inner membrane, a second receptor complex is needed. The major component of this is tonB, a 27kDa protein that facilitates energy transfer from the proton motive force to outer receptors Pfam: Gram-negative bacterial TonB protein no signal peptide 1 TMH; Function unclear.
  
 
 0.692
azo0708
Conserved hypothetical secreted protein. Homology to ne1626 of N. europaea of 46% (trembl|Q82U75) no domains predicted signal peptide TMH in signal peptide; Conserved hypothetical protein.
  
 
 0.692
tonB2
Periplasmic biopolymer transport protein linking inner and outer membranes; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.
  
 
 0.692
azo1653
Putative Autotransporter,30% identity to TrEMBL;Q87UU2. Weak homology with hits in the DB. Signal Peptide present. No TMH reported present. Has PF03797;Autotransporter beta-domain;The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C terminus of the proteins it occurs in. The N terminus contains the variable passenger [...]
  
 
 
 0.667
azo3746
Hypothetical secreted protein. No homology to the data bank. No domains predicted. signal peptide no TMHs.
  
 
 0.617
fecA
Ferric-citrate outer membrane receptor,FecA.Involved in the recognition and internalization of ferric-citrate in E.coli. SPECIFIC RECEPTOR FOR THE SIDEROPHORE FERRIC PSEUDOBACTIN 358. InterPro: TonB-dependent receptor protein; High confidence in function and specificity.
  
     0.598
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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