STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo3045Probable lactonase; TREMBL:Q84HI5: 83% identity, 89% similarity from Azoarcus evansii (gene name refereed as ORF2) Haloalkane dehalogenase (EC 3.8.1.5). Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds leading to the formation of the corresponding primary alcohols halide ions and protons. Has a broad substrate specificity which includes mono- and di- chlorinated and brominated alkanes. The highest activity was found with 12-dibromoethane whereas low activity was measured with the analog 12-dichloroethane. InterPro: Alpha/beta hydrolase fold Descr [...] (257 aa)    
Predicted Functional Partners:
azo3049
ABC transporter permease protein; Branched-chain amino acid transport system typically composed of a periplasmic substrate-binding protein, one or two reciprocally homologous integral inner-membrane proteins and one or two peripheral membrane ATP-binding proteins that couple energy to the active transport system.The integral inner-membrane proteins translocate the substrate across the membrane. Similar to trembl|Q84HI2 (91%), to trembl|Q89VI1 (47%), to sprot|LIVH_ECOLI (27%) and to sprot|BRAD_PSEAE (30%). Pfam (PF02653): Binding-system dependent bacterial transporters (araH, livH/limM [...]
 
  
  0.809
livG1
ATP-binding cassette (ABC) transporters are multidomain membrane proteins, responsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. ATP-binding protein is for coupling the energy of ATP hydrolysis to conformational changes in the transmembrane domains. Similar to trembl|Q84HI3 (79%) and to sprot|LIVG_ECOLI (37%). Pfam (PF00005): ABC transporter ProSite (PS50101): ATP/GTP-binding site motif A (P-loop) Smart (SM00382): AAA ATPase superfamily; Specificity unclear.
    
  0.789
livM3
Putative branched-chain amino acid transport permease. Homology to livM of E. coli of 31% as well as genes coding for a new pathway of aerobic benzoate meabolisme in A. evansii (77%). Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane. Pfam: Branched-chain amino acid transport system. probable signal peptide probable 8 TMHs; Specificity unclear.
    
  0.784
azo3046
ATP-binding cassette (ABC) transporters are multidomain membrane proteins, responsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. ATP-binding protein is for coupling the energy of ATP hydrolysis to conformational changes in the transmembrane domains. Similar to trembl|Q84HI4 (80%) and to trembl|Q89VH8 (45%). Pfam (PF00005): ABC transporter Smart (SM00382): AAA ATPase superfamily ProSite (PS50101): ATP/GTP-binding site motif A (P-loop); Specificity unclear.
    
  0.783
bzdA
Probable benzoate-coa ligase; Entry name :- TREMBL:Q84HI0 Entry name :-TREMBL:Q8VUF1 InterPro IPR010071; AA_adenyl_dom. IPR000873; AMP-bind. IPR010192; MenE. Pfam PF00501; AMP-binding; 1 Identities = 414/532 (77%) Prediction: Non-secretory protein Signal peptide probability: 0.000 Number of predicted TMHs: 0; Family membership.
 
  
  0.765
azo3056
Probable enoyl-coa-hydratase/isomerase; Activity:- (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O Entry name :- TREMBL:Q84HH6 InterPro :-IPR001753; EnCoA_hydrtse. Pfam:- PF00378; ECH; 1. Number of predicted TMHs: 0 Identities = 452/553 (81%); Family membership.
 
 
 
 0.764
boxB
Benzoyl-CoA oxygenase component B. 85%; Function unclear.
 
     0.747
boxA
Benzoyl-CoA oxygenase component A. 84% 4Fe4S_ferredoxin. IPR001709; FPN_cyt_redctse. IPR001433; Oxred_FAD/NAD(P). Pfam:PF00037; Fer4; 2. PF00175; NAD_binding_1; 1; High confidence in function and specificity.
 
   
 0.686
aroK-2
Conserved hypothetical protein; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
 
   
 0.685
azo3053
Conserved hypothetical protein. Homology to an orf of A. evnasii of 79% (trembl|Q84HH9). no domains predicted. no signal peptide. no TMHS.
 
     0.642
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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