STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo3054Aldehyde dehydrogenase (NAD+). Homology to the aldehyce dehydrogenase of the of the benzoate gene cluster of A. evansii of 81% (trembl|Q84HH8). Aldehyde dehydrogenases are enzymes which oxidize a wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor. Here clustered with genes involved in the aerobic benzoate metabolism. InterPro: Aldehyde dehydrogenase family (IPR002086) Pfam: Aldehyde dehydrogenase family no signal peptide no TMHs; High confidence in function and specificity. (525 aa)    
Predicted Functional Partners:
paaE
Probable phenylacetic acid degradation NADH oxidoreductase paaE. Homology to paaE of E. coli of 50% (sprot|PAAE_ECOLI). Probable PART OF A MULTICOMPONENT OXYGENASE involved in aerobic degradation of phenylacetic acid. InterPro: Oxidoreductase FAD and NAD(P)-binding domain(IPR001433); 2Fe-2S Ferredoxin (IPR006057); Ferredoxin (IPR001041); NADH: cytochrome b5 reductase (CBR) (IPR001834) Pfam: Oxidoreductase FAD-binding domain; Oxidoreductase NAD-binding domain; 2Fe-2S iorn-sulfur cluster binding domain no signal peptide no TMHs; High confidence in function and specificity.
  
  
 0.791
gltB
Ferredoxin-dependent glutamate synthase,; Specificity unclear.
  
 
 0.791
boxA
Benzoyl-CoA oxygenase component A. 84% 4Fe4S_ferredoxin. IPR001709; FPN_cyt_redctse. IPR001433; Oxred_FAD/NAD(P). Pfam:PF00037; Fer4; 2. PF00175; NAD_binding_1; 1; High confidence in function and specificity.
 
 
 0.774
paaB
Phenylacetic acid degradation protein PaaB; May be part of a multicomponent oxygenase involved in phenylacetyl-coa hydroxylation. Phenylacetic acid aerobic catabolism pathway, TREMBL:Q8XS76 (75% identity); SWISSPROT:P76078 (61% identity); High confidence in function and specificity.
 
   
 0.769
paaC
Probable phenylacetic acid degradation protein PaaC. Homology to paaI of P. putida of 46% (trembl|O84983). Part of a catabolic pathway of phenylacetic acid. These proteins forms part of a dioxygenase complex. Interpro: Phenylacetic acid catabolic (IPR007814) Pfam: Phenylacetic acid catabolic protein (PF05138) no signal peptide no TMHs; High confidence in function and specificity.
  
   
 0.763
paaI
Phenylacetic acid degradation protein PaaI; Phenylacetic acid aerobic catabolism. Similar to TREMBL:Q9F9V0 (74% identity); SWISSPROT:P76084 (48% identity). InterPro (IPR003736): Phenylacetic acid degradation-related protein. Pfam (DUF157): Uncharacterized protein PaaI, COG2050; High confidence in function and specificity.
  
  
 0.762
paaD
Probable pheylacetic acid degradation protein PaaD. Homology to phaH of P. putida of 54% (trembl|Q88HS8) Interpro: Protein of unknown function DUF59 (IPR002744) Pfam: Domain of unknoen function DUF59 (PF01883). Domain of unknown function DUF59;IPR002744; This family includes prokaryotic proteins of unknown function. The family also includes PhaH O84984 from Pseudomonas putida. PhaH forms a complex with PhaF O84982, PhaG O84983 and PhaI O84985,which hydroxylates phenylacetic acid to 2-hydroxyphenylacetic acid. So members of this family may all be components of ring hydroxylating complex [...]
  
  
 0.759
paaA
Phenylacetic acid degradation protein [paaA],86% identity(91% similarity) to TrEMBL;Q9F9U9. 72% identity to TrEMBL;Q7WGX6, Q8XS77 Has PF05138, Phenylacetic acid catabolic protein;IPR007814, PaaA_PaaC; This family includes proteins such as PaaA and PaaC that are part of a catabolic pathway of phenylacetic acid. These proteins may form part of a dioxygenase complex. No Signal Peptide or TMH present; High confidence in function and specificity.
  
   
 0.758
azo3056
Probable enoyl-coa-hydratase/isomerase; Activity:- (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O Entry name :- TREMBL:Q84HH6 InterPro :-IPR001753; EnCoA_hydrtse. Pfam:- PF00378; ECH; 1. Number of predicted TMHs: 0 Identities = 452/553 (81%); Family membership.
 
  
  0.706
acS1
Acetyl-coenzyme A synthetase enables the cell to use acetate during aerobic growth to generate energy via the tca cycle, and biosynthetic compounds via the glyoxylate shunt. acetylates chey, the response regulator involved in flagellar movement and chemotaxis. Entry name SWISSPROT:ACSA_ECOLI Prim. accession # P27550 Identities = 145/546 (26%) Pfam PF00501; AMP-binding; 1. InterPro IPR000873; AMP-bind. Pfam PF00501; AMP-binding; 1. Number of predicted TMHs: 0; Family membership.
   
 0.691
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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