STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Experiments
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[Homology]
Score
azo3063Conserved hypothetical membrane protein. Homology to CV2531 of C. violaceum of 37%. Tigrfam: 2A78: Carboxylate/Amino Acid/Amine Tranporter. Pfam: Integral membrane protein DUF6. probable 10 TMHs. probable signal peptide; Conserved hypothetical protein. (312 aa)    
Predicted Functional Partners:
uppS
Probable undecaprenyl pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
     
  0.603
azo2910
ATP-binding cassette (ABC) transporters form a large family of proteins responsible for translocation of a variety of compounds across biological membranes. They are composed of two transmembrane domains responsible for binding and transport and two nucleotide-binding domains responsible for coupling the energy of ATP hydrolysis to conformational changes in the TMDs, TREMBL:Q8FZX0 (58% identity); TREMBL:Q8U6Y9 (59% identity). InterPro (IPR003593): AAA ATPase. InterPro (IPR001687): ATP/GTP-binding site motif A (P-loop). InterPro (IPR003439): ABC transporter. Pfam (PF00005): ABC transpor [...]
    
 0.485
brkB
Exoribonuclease II; Putative Ribonuclease RNASE_BN Protein, 28% identity to TrEMBL;Q8XPH6. Has PF03631, Ribonuclease BN-like family;IPR004664, RNase_BN: This family contains integral membrane proteins with 5 to 6 predicted transmembrane spans. The family include ribonuclease BN that is involved in tRNA maturation P32146. This family of proteins does not seem to contain any completely conserved polar residues that would be expected in a nuclease enzyme, suggesting that many members of this family may not have this catalytic activity; Conserved hypothetical protein.
     
 0.464
lrp1
Leucine-responsive regulatory protein. Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different opreons; Lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes. Similar to SWISSPROT: sprot|LRP_ECOLI (40% Escherichia coli, leucine-responsive regulatory protein Lrp) InterPro: IPR000485 HTH_AsnC_lrp. Pfam: PF01037 AsnC family. HTH reporting nucleic acid binding motif; High confidence in function and specificity.
       0.461
ispB
Octaprenyl-diphosphate synthase; Polyprenyl synthetase,82% identity to TrEMBL;Q5P1Y1. Has Pfam;PF00348, Polyprenyl synthetase.(IPR000092,Polyprenyl_synt)A variety of isoprenoid compounds are synthesized by various organisms. For example in eukaryotes the isoprenoid biosynthetic pathway is responsible for the synthesis of a variety of end products including cholesterol, dolichol, ubiquinone or coenzyme Q. In bacteria this pathway leads to the synthesis of isopentenyl tRNA, isoprenoid quinones, and sugar carrier lipids. Among the enzymes that participate in that pathway, are a number of [...]
    
  0.459
ispA
Geranyltranstransferase; Geranylgeranyl pyrophosphate synthetase chloroplast precursor (GGPP synthetase) (GGPS) [Includes: Dimethylallyltransferase (EC 2.5.1.1); Geranyltranstransferase (EC 2.5.1.10); Farnesyltranstransferase (EC 2.5.1.29)]. catalyzes the trans-addition of the three molecules of ipp onto dmapp to form geranylgeranyl pyrophosphate. InterPro: Polyprenyl synthetase; High confidence in function and specificity; Belongs to the FPP/GGPP synthase family.
    
  0.459
azo2371
30S ribosomal protein S4, truncated. Homology of aa 1 to 108 with rpsD of N. europaea of 67% (sprot|RS4B_NITEU(SRS)). With S5 and S12 plays an important role in translational accuracy (By similarity). Pfam: Ribosomal protein S4/S9 n-terminal domain. no signal peptide. no TMHs; Family membership; Belongs to the universal ribosomal protein uS4 family.
     
  0.455
rpsD
30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
     
  0.455
azo1044
Conserved hypothetical membrane protein. Homology to ebA4769 of Azoarcus sp. EbN1 of 53% (gnl|keqq|eba:ebA4769(KEGG)). Pfam: Cobalt transport protein. signal peptide. 3 TMHs; Family membership.
    
  0.435
cbiQ
Putative cobalt transport system permease protein; Part of the ABC transporter complex cbiKMQO involved in cobalt import. Similar to the cobalt transport membrane protein, CbiQ in A. pleuropneumoniae; Function unclear.
    
  0.435
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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