STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
accC2This protein is a component of the acetyl coenzyme a carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-coa. Entry name TREMBL:Q8PDU1 InterPro IPR001882; Biotin_BS. IPR005482; Biotin_carb_C. IPR000089; Biotin_lipoyl. IPR005479; CPase_L_D2. IPR005481; CPase_L_N. Pfam PF02785; Biotin_carb_C; 1. PF00364; Biotin_lipoyl; 1. PF00289; CPSase_L_chain; 1. PF02786; CPSase_L_D2; 1. Identities = 382/661 (57%) Preediction: Non-secretory protein Signal peptide probability: 0.000 [...] (666 aa)    
Predicted Functional Partners:
azo3070
Probable carboxyltransferase subunit of acetyl-CoA carboxylase; Activity:- ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA Entry name:-TREMBL:Q7WDP0 InterPro:- IPR000022; Carboxyl_trans. Pfam:-PF01039; Carboxyl_trans; 1. Identities = 413/535 (77%) Number of predicted TMHs: 0 Prediction: Non-secretory protein Signal peptide probability: 0.098; Family membership.
 0.995
accD
Probable acetyl-coenzyme A carboxylase carboxyl transferase subunit b; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family.
 0.992
accA
Probable acetyl-coenzyme a carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
 
 0.991
pccB
Probable propionyl-coa carboxylase beta subunit; Activity:- ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA Entry name:-TREMBL:Q8U9Y9 Prim. accession # Q8U9Y9 InterPro:-IPR000438; ACoACC_transB. IPR000022; Carboxyl_trans. Pfam:- PF01039; Carboxyl_trans; 1. Identities = 363/511 (71%) Number of predicted TMHs: 0; Family membership.
 0.980
accB
Probable biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
 
 0.980
paaG5
Probable enoyl-CoA hydratase :- COULD POSSIBLY OXIDIZES FATTY ACIDS USING SPECIFIC COMPONENTS (BY SIMILARITY). Entry name :- SWISSPROT:PAAG_ECOLI InterPro :-IPR001753; EnCoA_hydrtse. Pfam:- PF00378; ECH; 1. Identities = 75/247 (30%) Number of predicted TMHs: 0; Family membership; Belongs to the enoyl-CoA hydratase/isomerase family.
 0.948
azo3081
Probable acyl-coa dehydrogenase; Entry name:- TREMBL:Q89LX4 Identities = 310/374 (82%) InterPro IPR006089; Acyl-CoA_dh. IPR006090; Acyl-CoA_dh_C. IPR006091; Acyl-CoA_dh_M. IPR006092; Acyl-CoA_dh_N. IPR009075; AcylCoADH_C_like. IPR009100; AcylCoA_dehyd_NM. Pfam PF00441; Acyl-CoA_dh; 1. PF02770; Acyl-CoA_dh_M; 1. PF02771; Acyl-CoA_dh_N; Family membership.
 
 0.943
azo0044
Conserved hypothetical urea amidolyase-related protein. Homology to ybgK of E. coli of 36% (sprot|YBGK_ECOLI). InterPro: DUF183 (IPR003778) Uncharacterized domain in proteins of unknown function. This domain is found in a multifunctional enzyme, urea amidolyase, from yeast. Pfam: DFU182, uncharcterized ACR,COG1984 no signal peptide no TMHs; Function unclear.
 
 0.938
mvaB
Hydroxymethylglutaryl-CoA lyase, MvaB. It catalyses the conversion of (S)-3-hydroxy-3-methylglutaryl-CoA to acetyl-CoA and acetoacetate during the final step of ketogenesis and leucine catabolism. Similar to trembl|Q8QGJ4 (60%) and to pir|H83394 (56%). InterPro (PF00682): HMG-CoA Lyase-like family; High confidence in function and specificity.
 
 0.923
fadB1
Probable enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase; Alpha-subunit of fatty acid oxidation complex. Entry name TREMBL:Q8G968 Prim. accession # Q8G968 Identities = 373/642 (58%) InterPro IPR006108; 3HCDH_C. IPR006176; 3HCDH_N. Prediction: Non-secretory protein Signal peptide probability: 0.000 Number of predicted TMHs: 0 IPR008927; 6DGDH_C_like. IPR001753; EnCoA_hydrtse. Pfam PF00725; 3HCDH; 1. PF02737; 3HCDH_N; 1. PF00378; ECH; 1; Family membership.
  
 0.914
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: medium (56%) [HD]
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