Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
trkA1Potassium uptake protein. Part of the constitutive potassium transport systems trkG and trkH. May regulate the transport activity of trkG and trkH systems. Binds to NAD+ and NADH.Peripherally bound to the inner side of the inner membrane via the trkG and trkH proteins. 41% NAD_BS. IPR006037; TrkAC. IPR003148; TrkA_N. Pfam:PF02080; TrkA_C; 1. PF02254; TrkA_N; 1. Pfam:KTN: NAD-binding domain; Specificity unclear. (226 aa)    
Predicted Functional Partners:
trkH1
Membrane component of the potassium uptake system. 38% Cat_transpt. IPR004772; K_transptTrk. Pfam: PF02386; TrkH; 1. SignalP.present. TMHelix:9; High confidence in function and specificity.
 
 
 0.987
trkH2
Putative potassium system uptake protein; Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA; Belongs to the TrkH potassium transport family.
  
 
 0.760
moaE
Molybdenum cofactor biosynthesis protein E; Molybdopterin converting factor subunit 2 (MPT synthase subunit 2) (Molybdopterin synthase subunit 2). Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group; High confidence in function and specificity.
   
    0.629
kdpD2
Probable sensor for high-affinity potassium transport system,; High confidence in function and specificity.
     
 0.603
azo3093
Two component system transcriptional regulatory protein, 53% Identity to TrEMBL;Q7W532,Q8XUU6. Has SMART;SM00448,REC, cheY-homologous receiver domain;IPR001789;CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues. Has OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription] Has PF00486, Transcriptional regulatory protein, C terminal;IPR001867 Trans_reg_C; This domain is almost al [...]
       0.596
nadE
NAD(+) synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
  0.593
hemD
HemD protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
    0.579
ihfA
Integration host factor alpha-subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family.
    
   0.561
azo0795
Probable glutathione-regulated potassium-efflux system protein (K(+)/H(+) antiporter). Transport system that facilitate potassium-efflux possibly by potassium-proton antiport. 50% Na_H_porter.IPR006037; TrkAC.IPR003148; TrkA_N. Pfam: PF00999; Na_H_Exchanger; 1.PF02080; TrkA_C; 1.PF02254; TrkA_N; 1. TMhelix: 11; High confidence in function and specificity; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.
     
 0.530
azo3122
Conserved hypothetical protein; SUN protein; Specificity unclear; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
    0.481
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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