STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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[Homology]
Score
nosZNitrous-oxide reductase. Homology to nosZ of a. eutrophus of 78% (sprot|NOSZ_ALCEU) Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity). no domains probable signal peptide no TMHs met_pdase_I: methionine aminopeptidas; High confidence in function and specificity. (644 aa)    
Predicted Functional Partners:
norC
Nitric-oxide reductase subunit C (EC 1.7.99.7) (Nitric oxide reductase cytochrome c subunit) (NOR small subunit).COMPONENT OF THE ANAEROBIC RESPIRATORY CHAIN THAT TRANSFORMS NITRATE TO DINITROGEN (DENITRIFICATION).54% IPR000345; CytC_heme_BS. Pfam; PF00034; Cytochrom_C; 1. SignalP: present TMHelix:1; High confidence in function and specificity.
 
 
 0.994
norB
Nitric-oxide reductase subunit B (EC 1.7.99.7) (Nitric oxide reductase cytochrome b subunit). 69% similarity to the P.stutzeri NorB protein. COMPONENT OF THE ANAEROBIC RESPIRATORY CHAIN THAT TRANSFORMS NITRATE TO DINITROGEN (DENITRIFICATION). NorB IS THE CATALYTIC SUBUNIT OF THE ENZYME COMPLEX. SHOWS PROTON PUMP ACTIVITY ACROSS THE MEMBRANE IN DENITRIFYING BACTERIAL CELLS. THE MONONITROGEN REDUCTION IS PROBABLY COUPLED TO ELECTRON TRANSPORT PHOSPHORYLATION.Belongs to the heme-copper respiratory oxidase family. Swiss Prot: Q59647. IPR000883; COX1. PF00115; COX1; 1. TMHMM:predicted trans [...]
  
 
 0.994
nosRa
Transcriptional activator for nitrous-oxide reductase, N-terminal domain; Regulatory protein nosR. Transcriptional activation of the nitrous-oxide reductase gene nosZ. Similar to SWISSPROT: sprot|NOSR_PSEST (37% Pseudomonas stutzeri (Pseudomonas perfectomarina), regulatory protein NosR). TMHMM reporting 5 transmembrane helices. HTH reporting nucleic acid binding motif; High confidence in function and specificity.
 
  
 0.989
nosD
Copper-binding periplasmic protein precursor. INVOLVED IN COPPER PROCESSING AND TRANSPORT; IN THE ASSEMBLY OF THE COPPER CHROMOPHORES OF NITROUS OXIDE REDUCTASE.Part of the ABC transporter complex nosDFY involved in copper import. Similar to the putative periplasmic-binding protein nosD precursor from: P.fluorescens (36%)TREMBL:Q9F0W3 InterPro:IPR006633; CASH. IPR007742; NosD.IPR006626; PbH1. Pfam:PF05048; NosD; 1. Signal peptide: present; High confidence in function and specificity.
 
  
 0.984
nosY
Membrane protein nosY precursor.INVOLVED IN COPPER PROCESSING. Part of the ABC transporter complex nosDFY involved in copper import. Probably responsible for the translocation of the substrate across the membrane. 43% Similar to the copper permease protein, nosY in P.stutzeri. TREMBL:Q9F0W1 InterPro:IPR001117; Cu-oxidase. SignalP: present. Number of predicted TMHs:6; High confidence in function and specificity.
 
  
 0.978
nosRb
Conserved hypothetical transcriptional activator for nitrous-oxide reductase, C-termial domain. Homology to nosr (C-terminal domain) of Azoarcus sp. EbN1 of 74% (gnl|keqq|eba:ebB224(KEGG)). no domains predicted. no signal peptide. probable 3 TMHs; Conserved hypothetical protein.
  
  
 0.962
nosL
Putative NosL protein. Homology to nosL of S. meliloti of 38% (trembl|O07331). NosL is one of the accessory proteins of the nos (nitrous oxide reductase) gene cluster. NosL is a monomeric protein of 18,540 MW that specifically and stoichiometrically binds Cu(I). The copper ion in NosL is ligated by a Cys residue, and one Met and one His are thought to serve as the other ligands. It is possible that NosL is a copper chaperone involved in metallocenter assembly. probable signal peptide no TMHs; Family membership.
 
  
 0.929
nosF
Copper transport ATP-binding protein nosF.INVOLVED IN COPPER PROCESSING/TRANSPORT.Part of the ABC transporter complex nosDFY involved in copper import. 3% ABC_tran; 1. InterPro:IPR003593; AAA_ATPase. IPR003439; ABC_transporter. InterPro:PS50101:ATP/GTP-binding site motif A (P-loop). InterPro:SM00382:AAA ATPase superfamily; High confidence in function and specificity.
 
  
 0.877
nifH
Putative nitrogenase iron protein; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein; Belongs to the NifH/BchL/ChlL family.
     
 0.875
nifD
Nitrogenase molybdenum-iron protein alpha chain (EC 1.18.6.1) (Nitrogenase component I) (Dinitrogenase). The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components: the iron protein and the molybdenum-iron protein; High confidence in function and specificity.
     
 0.866
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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