STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
lysCAspartate kinase (AK) catalyzes the phosphorylation of aspartate. The product of this reaction can then be used in the biosynthesis of lysine or in the pathway leading to homoserine, which participates in the biosynthesis of threonine, isoleucine and methionine. Similar to trembl|Q8RU02 (80%) and to pir|C83531 (74%). Pfam (PF00696): Amino acid kinase family Pfam (PF01842): two ACT domain; High confidence in function and specificity; Belongs to the aspartokinase family. (408 aa)    
Predicted Functional Partners:
asd
Asd protein; Aspartate-semialdehyde dehydrogenase, an enzyme involved in the biosynthesis of various amino acids from aspartate. Similar to sprot|DHAS_ECOLI (67%) and to trembl|Q845W2 (75%). Pfam: Semialdehyde dehydrogenase,dimerisation Pfam: Semialdehyde dehydrogenase, NAD binding; High confidence in function and specificity.
 
 
 0.996
hom
Homoserine dehydrogenase catalyzes NAD-dependent reduction of aspartate beta-semialdehyde into homoserine. This reaction is the third step in a pathway leading from aspartate to homoserine. Similar to TREMBL:Q9RAM9 (77%) and to pir|DEPSHA(PIR (Georgetown University) (56%). Pfam: Homoserine dehydrogenase; High confidence in function and specificity.
 0.966
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
  0.930
argG
ArgG protein; Argininosuccinate synthase, argG. Similar to SWISSPROT:ASSY_NITEU (81%). Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate. InterPro (PF00764): Argininosuccinate synthase InterPro (TIGR00032): Argininosuccinate synthase; High confidence in function and specificity.
  
 
 0.928
nadB
L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.
    
 0.919
asn
Asparagine synthase catalyze the conversion of aspartate to asparagine. Similar to trembl|Q82VG1 (45%) and to trembl|Q7USD1 (27%). Pfam (PF00733): Asparagine synthase; Family membership.
  
 
 0.917
azo0436
L-asparaginase precursor (EC 3.5.1.1) (L-asparagine amidohydrolase) (L-ASNase); Family membership.
     
 0.916
pyrB
Aspartate carbamoyltransferase (Aspartate transcarbamylase) (Carbamylaspartotranskinase) (ATCase); High confidence in function and specificity; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
     
 0.916
thrC
ThrC protein; Threonine synthase is involved in threonine biosynthesis. It catalyses the conversion of O-phospho-L-homoserine and water into L-threonine and orthophosphate,using pyridoxal phosphate as a cofactor. The pyridoxal-phosphate binding site is a Lys (K) residue. The enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. Similar to trembl|Q8XZR7 (68%), to sprot|THRC_METGL (69%) and to sprot|THRC_PSEAE (42%). TIGRFAM: thrC, threonine synthase Pfam (PF00291): Pyridoxal-phosphate dependent enzyme; High confidence in f [...]
  
 
 0.904
metH
Probable methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.885
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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