STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Coexpression
Experiments
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[Homology]
Score
azo3138Putative chromosomal replication initiator protein; Region start changed from 3447165 to 3447246 (-81 bases); Belongs to the DnaA family. (229 aa)    
Predicted Functional Partners:
dnaN
DNA-directed DNA polymerase; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of repl [...]
 
 
 0.987
dnaA
Chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
  
 
 0.886
dnaB
DnaB protein; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily.
   
 
 0.847
azo3137
Conserved hypothetical membrane protein. This is a family of hypothetical proteins. A number of the sequence records state they are transmembrane proteins or putative permeases.It is not clear what source suggested that these proteins might be permeases and this information should be treated with caution. TREMBL:Q82Y01: 39% identity; 58% similarity. TREMBL:Q8XW51: 37% identity; 53% similarity. InterPro:IPR002549 Pfam: PF01594:Protein of unknown function DUF70 Signal P predicted signal peptide and TMHMM predicted transmembrane helices; Conserved hypothetical protein.
 
   
 0.818
azo3139
Haloacid dehalogenase-like hydrolase family is structurally different from the alpha/beta hydrolase family (abhydrolase). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. Similar to trembl|Q82XZ3 (63%) and to pir|B83604 (47%). Pfam (PF00702): haloacid dehalogenase-like hydrolase; Family membership.
       0.730
rpmE
50S ribosomal protein L31; Binds the 23S rRNA.
  
    0.702
gmhA
Putative phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
   
 
 0.686
ribE
Riboflavin synthase alpha chain (EC 2.5.1.9). Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1-D)- ribityl-amino-24(1H3H)-pyrimidinedione and L-34-dihydrohy-2- butanone-4-phosphate via 67-dimethyl-8-lumazine. The alpha subunit catalyzes the dismutation of 67-dimethyl-8-lumazine to riboflavin and 5-amino-6-(1-D)-ribityl-amino-24(1H3H)- pyrimidinedione. ribE: riboflavin synthase alpha subunit; High confidence in function and specificity.
   
    0.642
pcnB
Probable poly(A) polymerase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
 
   
 0.630
purM
Phosphoribosylformylglycinamidine cyclo-ligase (Phosphoribosyl-aminoimidazole synthetase) (Phosphoribosylaminoimidazole synthetase) (AIR synthase) (AIR synthetase) (AIRS) InterPro: Phosphoribosylformylglycinamidine cyclo-ligase; High confidence in function and specificity.
  
  
 0.602
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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