Phosphatidate cytidylyltransferase :- catalytic activity ctp + phosphatidate = diphosphate + cdp-diacylglycerol. pathway :-phospholipid biosynthesis. Entry name:- CDSA_ECOLI Primary accession number :- P06466 InterPro:- IPR000374; PC_trans. Identities = 89/252 (35%) Pfam PF01148; CTP_transf_1; 1. Number of predicted TMHs: 7 Prediction: Signal peptide Signal peptide probability: 1.0; Family membership; Belongs to the CDS family.

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (PGP synthase). It catalyses the conversion of CDP-diacylglycerol and glycerol-3-phosphate to CMP and 3-(3-phosphatidyl)-glycerol 1-phosphate in the commited step to the synthesis of acidic phospholipids. It is an integral membrane protein. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. Entry name :-SWISSPROT:PGSA_ECOLI Prim. accession # P06978 Identities = 50% InterPro IPR000462; CDP-OH_P_trans. I [...]

Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

AAS bifunctional protein [Includes: 2-acylglycerophosphoethanolamine acyltransferase (2-acyl-GPE acyltransferase); Acyl-acyl carrier protein synthetase (Acyl-ACP synthetase)]. PLAYS A ROLE IN LYSOPHOSPHOLIPID ACYLATION. TRANSFERS FATTY ACIDS TO THE 1-POSITION VIA AN ENZYME-BOUND ACYL-ACP INTERMEDIATE IN THE PRESENCE OF ATP AND MG(2+). ITS PHYSIOLOGICAL FUNCTION IS TO REGENERATE PTDETN FROM 2-ACYL-GPE FORMED BY TRANSACYLATION REACTIONS OR DEGRADATION BY PHOSPHOLIPASE A1, TREMBL:Q8FEA6 (52% identity); SWISSPROT:P31119 (52% identity). Pfam (PF00501): AMP-binding enzyme. Pfam (PF01553): Ac [...]

Probable homoserine kinase; ThrH encodes a protein with an in vivo homoserine-kinase-like activity in P. aeruginosa. Homoserine kinase,the product of the thrB gene, catalyzes an obligatory step of threonine biosynthesis. Similar trembl|Q9I2Y2 (62%). Pfam (PF00702): haloacid dehalogenase-like hydrolase; Function unclear.

Phosphoserine phosphatase, SerB, catalyzes the final step in serine biosynthesis in E. coli. It hydrolyses the phosphate group from phosphoserine to yield serine. Similar to trembl|Q82X56 (54%) and to sprot|SERB_ECOLI (37%). TIGRFAM: phosphoserine phosphatase SerB Pfam (PF00702): haloacid dehalogenase-like hydrolase; Specificity unclear.

Probable threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.

TrpB protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.