Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
azo3178Conserved hypothetical protein; Similar to TREMBL:Q82SR1 (47% identity). (259 aa)    
Predicted Functional Partners:
azo3282
Conserved hypothetical polysaccharide chain length determinant protein. Homology to ebA4249 of Azoarcus sp. EbN1 of 66%. No signal peptide. 3 TMHS. Pfam: Wzz = Chain length determinant protein. This family includes proteins involved in lipopolysaccharide (lps) biosynthesis. This family comprises the whole length of chain length determinant protein (or wzz protein) that confers a modal distribution of chain length on the O-antigen component of lps. This region is also found as part of bacterial tyrosine kinases such as ETK_ECOLI; Family membership.
  
     0.748
azo3280
Conserved hypothetical protein.
  
     0.735
azo1777
Hypothetical LuxR-family transcriptional regulator. Similarity to other known proteins (dctR or narP or esaR) only in the domain part. Pfam: PF00196 Bacterial regulatory proteins, luxR family. HTH reporting nucleic acid binding motif. The 'helix-turn-helix' DNA-binding motif of this protein is located in the C-terminal section of the sequence; Conserved hypothetical protein.
  
 
 0.732
azo3275
Conserved hypothetical membrane protein. Homology to NE1797 of Nitrosomonas europaea of 33% (trembl|Q82TS7(SRS)). no domains predicted. signal peptide. 7 TMHs; Conserved hypothetical protein.
  
     0.726
azo3192
Putative two component sensor histidine kinase,; Family membership.
  
   
 0.721
azo3381
Hypothetical signaling protein.
    
 0.716
azo3267
Conserved hypothetical membrane protein. Homology to RferDRAFT_3275 of Rhodoferax ferrireducens of 46%. Pfam: O-Antigen Polymerase. This group of bacterial proteins is involved in the synthesis of O-antigen, a lipopolysaccharide found in the outer membrane in gram-negative bacteria. The enzyme is coded for by the gene wzy which is part of the O-antigen gene cluster. No signal peptide. 9 TMHs; Family membership.
  
     0.706
azo3276
Conserved hypothetical protein; Possibly related to cell surface polysaccharide biosynthesis, due to the presence of the gene in a polysaccharide synthesis gene cluster; Function unclear.
  
     0.703
wza
Conserved hypothetical polysaccharid export protein. Homology to wza of Azoarcus sp. EbN1 of 80%. Pfam: Polysaccharide biosynthesis/export protein. This is a family of periplasmic proteins involved in polysaccharide biosynthesis and/or export. No TMHs. Signal peptide present., ; Family membership.
  
     0.699
azo0689
GGEF/EAL/PAS/PAC-domain containing protein, sym; pNGR234a) / TREMBL: trembl|Q7NYX4 (40% Chromobacterium violaceum, cv1148) InterPro: IPR000160 GGDEF. IPR000014 PAS. IPR000700 PAS-assoc_C. IPR001633 EAL. Pfam: PF00990 GGDEF domain. PF00989 PAS domain. PF00785 PAC motif. PF00563 EAL domain. TIGRFAM:TIGR00229 PAS domain S-box. TIGR00254 putative diguanylate cyclase (GGDEF) domain.
    
 0.691
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.