STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo3181Probable dehydrogenase protein; Region start changed from 3493365 to 3493173 (-192 bases). (324 aa)    
Predicted Functional Partners:
prpE
Probable propionyl-CoA synthetase; Catalysis the synthesis of propionyl-CoA from propionate and CoA. Also converts acetate to acetyl-CoA but with a lower specific activity (By similarity). Catalysis of the reaction:- ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA Entry name SWISSPROT:PRPE_SALTY InterPro IPR000873; AMP-bind. Pfam PF00501; AMP-binding; 1. Identities = 372/627 (59%) Number of predicted TMHs: 1; High confidence in function and specificity.
    
 0.949
pccA
Probable propionyl-CoA carboxylase alpha chain; Activity:- ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA Entry name :- Q8U9Z4 Primary accession number:- Q8U9Z4 InterPro:- IPR001882; Biotin_BS. IPR005482; Biotin_carb_C. IPR000089; Biotin_lipoyl. IPR005481; CPase_L_N. IPR005479; Cphp_synth_L_D2. Pfam:- PF02785; Biotin_carb_C; 1. PF00364; Biotin_lipoyl; 1. PF00289; CPSase_L_chain; 1. PF02786; CPSase_L_D2; 1. Identities = 400/673 (59%) Prediction: Non-secretory protein Signal peptide probability: 0.000 Number of predicted TMHs: 0; Family membership.
     
 0.927
acsB
Probable acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
     
 0.927
yhdH
TREMBL:Q881C6:69% identity; 83% similarity. Alcohol dehydrogenase (EC: 1.1.1.1) (ADH) catalyzes the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD: Ethanol + NAD = Acetaldehyde + NADH Protein yhdH. InterPro:IPR002085; Adh_zn_family. Pfam:PF00107; ADH_zinc_N; FAD binding domain InterPro: Zinc-containing alcohol dehydrogenase superfamily TIGRFAM:tdh: L-threonine 3-dehydrogenase; High confidence in function and specificity.
  
  
 
0.923
fadfX
Probable acyl-CoA dehydrogenase; Activity:- Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. Entry name TREMBL:Q9AHX9 Prim. accession # Q9AHX9 InterPro IPR006089; Acyl-CoA_dh. IPR006090; Acyl-CoA_dh_C. IPR006091; Acyl-CoA_dh_M. IPR006092; Acyl-CoA_dh_N. IPR009075; AcylCoADH_C_like. IPR009100; AcylCoA_dehyd_NM. Pfam PF00441; Acyl-CoA_dh; 1. PF02770; Acyl-CoA_dh_M; 1. PF02771; Acyl-CoA_dh_N; 1. Identities = 244/375 (65%) Number of predicted TMHs: 0; Family membership.
  
 0.922
pta
Conserved hypothetical phosphate acetyltransferase. Homology to pta of R. palustris of 63% (tremblnew|CAE30007). InterPro: Phosphate acetyl/butaryl transferase (IPR002505); MaoC-like dehydrogenase domain (IPR002539). Pfam: MaoC like domain; Phosphate acetyl/butaryl transferase. no signal peptide. no TMHs; Conserved hypothetical protein.
  
 0.918
fadB1
Probable enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase; Alpha-subunit of fatty acid oxidation complex. Entry name TREMBL:Q8G968 Prim. accession # Q8G968 Identities = 373/642 (58%) InterPro IPR006108; 3HCDH_C. IPR006176; 3HCDH_N. Prediction: Non-secretory protein Signal peptide probability: 0.000 Number of predicted TMHs: 0 IPR008927; 6DGDH_C_like. IPR001753; EnCoA_hydrtse. Pfam PF00725; 3HCDH; 1. PF02737; 3HCDH_N; 1. PF00378; ECH; 1; Family membership.
   
 0.916
paaF1
Probable enoyl-CoA hydratase; COULD POSSIBLY OXIDIZES FATTY ACIDS USING SPECIFIC COMPONENTS (BY SIMILARITY). CATALYTIC ACTIVITY: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O. Entry name :- SWISSPROT:PAAF_ECOLI Prim. accession # P76082 InterPro :- IPR001753; EnCoA_hydrtse. Pfam :- PF00378; ECH; 1. Identities = 109/250 (43%) Prediction: Non-secretory protein Signal peptide probability: 0.000 Number of predicted TMHs: 0; Family membership; Belongs to the enoyl-CoA hydratase/isomerase family.
   
 0.897
pccB
Probable propionyl-coa carboxylase beta subunit; Activity:- ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA Entry name:-TREMBL:Q8U9Y9 Prim. accession # Q8U9Y9 InterPro:-IPR000438; ACoACC_transB. IPR000022; Carboxyl_trans. Pfam:- PF01039; Carboxyl_trans; 1. Identities = 363/511 (71%) Number of predicted TMHs: 0; Family membership.
     
 0.893
azo3180
Putative response regulator protein,; Family membership.
       0.718
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.