Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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[Homology]
Score
azo3189NDPsugar dehydrogenase; CapL protein. Required for the biosynthesis of type 1 capsular polysaccharide. InterPro: UDP-glucose/GDP-mannose dehydrogenase family gutA: pts system glucitol/sorbitol-s; Specificity unclear. (426 aa)    
Predicted Functional Partners:
mnaA
UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14) (UDP-GlcNAc-2- epimerase). Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc) the activated donor of ManNAc residues (By similarity). InterPro: UDP-N-acetylglucosamine 2-epimerase; High confidence in function and specificity.
 
 0.993
azo3193
Glycosyltransferase; Might transfer a sugar moiety directly to a lipd acceptor. Putative colanic biosynthesis UDP-glucose lipid carrier transferase. InterPro: Bacterial sugar transferase; Family membership.
  
 
 0.947
capD
Putative capsular polysaccharide biosynthesis protein; 48% Polysac_CapD. Pfam:PF02719; Polysacc_synt_2; 1; High confidence in function and specificity.
 
 
 0.938
gumD
Putative glycosyltransferase; 43% Bact_transf. Pfam:PF02397; Bac_transf; 1. TMhelix:5; Specificity unclear.
  
 
 0.905
glmU
UDP-N-acetylglucosamine pyrophosphorylase / diamine N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexap [...]
  
 
 0.901
xanB
Probable xanthan biosynthesis protein XanB. Homology to xanB of X. campestris of 60% (sprot|XANB_XANCP(SRS)) Xanthan biosynthesis protein XanB is a multifunctional enzyme including Mannose-6-phosphate isomerase (EC 5.3.1.8) (Phosphomannose isomerase) (PMI) (Phosphohexomutase)and Mannose-1-phosphate guanylyl transferase (GDP) (EC 2.7.7.22) (GDP-mannose pyrophosphorylase) (GMP). InterPro: ADP-glucose pyrophosphorylase (IPR005835); Mannose-6-phosphate isomerase type II (IPR001538) Pfam: Nucleotidyl transferase, Mannose-6-phosphate isomerase no signal peptide no TMHs; Family membership.
    
 0.896
rmlB
dTDP-glucose 46-dehydratase (EC 4.2.1.46). InterPro: NAD dependent epimerase/dehydratase family; High confidence in function and specificity; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.
  
 
 0.798
azo3188
Soluble lytic murein transglycosylase precursor (EC 3.2.1.-) (Slt70). Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N- acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity). InterPro: SLT domain; Family membership.
  
  
 0.790
azo3187
Conserved hypothetical serine protease. Homology to mucD of N. europaea of 50% (trembl|Q82XA8). InterPro: Serine proteases trypsin family (IPR001254); Chymotrypsin serin protease family (S1) (IPR001314). Pfam: Trypsin. signal peptide. no TMHs; Family membership.
       0.754
ligC
Hypothetical oxidoreductase yrbE (EC 1.-.-.-). TREMBL:Q93PS4:90% identity; 93% similarity. This group of enzymes utilise NADP or NAD, and is known as the GFO/IDH/MOCA family in Swiss-Prot. GFO is a glucose--fructose oxidoreductase, which converts D-glucose and D-fructose into D-gluconolactone and D-glucitol in the sorbitol-gluconate pathway. MOCA is a rhizopine catabolism protein which may catalyze the NADH-dependent dehydrogenase reaction involved in rhizopine catabolism. Other proteins belonging to this family include Gal80, a negative regulator for the expression of lactose and gala [...]
  
 
 0.732
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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