STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
folBFolB protein; Dihydroneopterin aldolase (DHNA). CATALYZES THE CONVERSION OF 78-DIHYDRONEOPTERIN TO 6-HYDROXYMETHYL-78-DIHYDROPTERIN. InterPro: Dihydroneopterin aldolase TIGRFAM: folB_dom: FolB domain; High confidence in function and specificity. (125 aa)    
Predicted Functional Partners:
folK
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK). InterPro: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase Pfam:7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; High confidence in function and specificity.
  
 
 0.995
folP
Dihydropteroate synthase (EC 2.5.1.15) (DHPS) (Dihydropteroate pyrophosphorylase). DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide (By similarity); High confidence in function and specificity.
 
 
 0.992
folE
FolE protein; GTP cyclohydrolase I (EC 3.5.4.16) (GTP-CH-I). folE: GTP cyclohydrolase I; High confidence in function and specificity.
  
 
 0.969
folC
Dihydrofolate synthase / Tetrahydrofolylpolyglutamate synthase; FolC bifunctional protein [Includes: Folylpolyglutamate synthase (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS); Dihydrofolate synthase (EC 6.3.2.12)]. Conversion of folates to polyglutamate derivatives; High confidence in function and specificity.
  
 
 0.843
pabB
Para-aminobenzoate synthase component I (EC 4.1.3.-) (ADC synthase). CATALYZES THE BIOSYNTHESIS OF 4-AMINO-4-DEOXYCHORISMATE (ADC) FROM CHORISMATE AND GLUTAMINE. InterPro: Anthranilate synthase component I and chorismate binding enzyme pabB: para-aminobenzoate synthase component I; Specificity unclear.
  
 
 0.709
azo3964
Conserved Hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
 
  
 0.674
ribD
AMP deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
  
 0.643
azo3118
Lyase, putative 6-pyruvoyl tetrahydrobiopterin synthase protein InterPro: 6-pyruvoyl tetrahydropterin synthase TIGRFAM: 6PTHBS: 6-pyruvoyl tetrahydrobiopterin synthase; Specificity unclear.
  
 
 0.642
FtsH
Probable cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
  
    0.610
birA
biotin--[acetyl-CoA-carboxylase] ligase; BirA bifunctional protein [Includes: Biotin operon repressor; Biotin--[acetyl-CoA-carboxylase] synthetase (EC 6.3.4.15) (Biotin--protein ligase)]. birA acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor, acetyl-coa:carbon- dioxide ligase. this protein also activates biotin to form biotinyl-5'-adenylate and transfers the biotin moiety to biotin-accepting proteins. InterPro: Biotin--acetyl-CoA-carboxylase ligase birA_ligase: biotin--acetyl-CoA-carboxyla; Specificity unclear.
  
  
 0.609
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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