STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gloA2Lactoylglutathione lyase; Glyoxalase I catalyzes the first step of the glyoxal pathway. S-lactoylglutathione is then converted by glyoxalase II to lactic acid. Similar to trembl|Q9HY85 (74%) and to sprot|LGUL_NEIMA (70%). Pfam (PF00903): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily ProDom (PD002334): Glyoxalase I; High confidence in function and specificity. (122 aa)    
Predicted Functional Partners:
gloB1
Probable hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid.
 
  
 0.910
gloB2
Probable hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid.
 
  
 0.907
ycbL
Hypothetical protein ycbL. TREMBL:Q7P1X5-63% identity. Interpro:IPR001279-Blactamase like Pfam-GlyoxylaseII family relationship. Phosphoribosylglycinamide synthetase,Respiratory chain NADH dehydrogenase; KH domain and RTX toxin acyltransferase family relationship. ispD: 4-diphosphocytidyl-2C-methyl-D-ery; High confidence in function and specificity.
  
  
 0.906
trpB
TrpB protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
    
  0.900
ilvA
Probable threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
   
 
 0.894
azo3229
Putative hydrolase; Probable Hydrogenase expression/formation protein hupH. SIMILARITY:Belongs to the hupH/hyaF family SPROT:P48340: 37% identity, 54% similarity InterPro: IPR002725; DUF45. Pfam: PF01863; DUF45 Nonsecretory protein (Signal P predicted) No transmembrane helices (TMHMM predicted); High confidence in function and specificity.
       0.793
icmF
Probable methylmalonyl-coa mutase protein; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.
    
 0.743
mutB
Probable Methylmalonyl-CoA mutase large subunit; FUNCTION: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates (By similarity). ACtivity:- (R)-2-Methylmalonyl-CoA = succinyl-CoA Entry name :- MUTB_PORGI Primary accession number :-Q59677 Identities = 467/679 (68%) InterPro :-IPR006159; Acid_CoA_mut_C. IPR006158; B12-binding. IPR006099; MMCoA_mutase. IPR006098; MMCoA_mutase_N. IPR006100; MMCoA_mutase_sub. Pfam PF02310; B12-binding; 1. PF01642; MM_CoA_mutase; 1. Prediction: Non-secretory protein Signal [...]
    
 0.641
azo3230
Probable Hypothetical protein Ta0487. trembl:Q7W4W1:50% identity, 62% similarity InterPro:IPR001453; MoCF_biosynth. Pfam: PF00994; MoCF_biosynth; 1. Eukaryotic and prokaryotic molybdoenzymes require a molybdopterin cofactor (MoCF) for their activity. The biosynthesis of this cofactor involves a complex multistep enzymatic pathway. One of the eukaryotic proteins involved in this pathway is the Drosophila protein cinnamon molyb_syn: molybdenum cofactor synthe No signal peptide. No transmembrane helices; Function unclear.
       0.617
azo3231
Conserved hypothetical membrane protein. Homology to ebA4352 of Azoarcus sp. EbN1 of 31% (gnl|keqq|eba:ebA4352(KEGG)). Has PF04401, Protein of unknown function (DUF540); IPR007496 DUF540; Uncharacterised bacterial integral membrane protein,possibly involved in cysteine biosynthesis. Speculated to be involved in sulphate transport. no signal peptide. 6 TMHs; Conserved hypothetical protein.
       0.617
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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