STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo3233Conserved hypothetical membrane protein. Homology to ne1459 of N. europaea of 49% (trembl|Q82UM4). Pfam: Cytochrome C assembly protein. no signal peptide. 8 TMHs; Conserved hypothetical protein. (274 aa)    
Predicted Functional Partners:
ffh
Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual componen [...]
       0.632
azo3230
Probable Hypothetical protein Ta0487. trembl:Q7W4W1:50% identity, 62% similarity InterPro:IPR001453; MoCF_biosynth. Pfam: PF00994; MoCF_biosynth; 1. Eukaryotic and prokaryotic molybdoenzymes require a molybdopterin cofactor (MoCF) for their activity. The biosynthesis of this cofactor involves a complex multistep enzymatic pathway. One of the eukaryotic proteins involved in this pathway is the Drosophila protein cinnamon molyb_syn: molybdenum cofactor synthe No signal peptide. No transmembrane helices; Function unclear.
       0.562
azo3231
Conserved hypothetical membrane protein. Homology to ebA4352 of Azoarcus sp. EbN1 of 31% (gnl|keqq|eba:ebA4352(KEGG)). Has PF04401, Protein of unknown function (DUF540); IPR007496 DUF540; Uncharacterised bacterial integral membrane protein,possibly involved in cysteine biosynthesis. Speculated to be involved in sulphate transport. no signal peptide. 6 TMHs; Conserved hypothetical protein.
       0.562
pilB2
Pilus assembly protein PilB is a component of the pilus biogenesis apparatus,; High confidence in function and specificity.
       0.545
pilC
Type 4 pilus biogenesis protein; Pilus assembly protein PilC is a component of the pilus biogenesis apparatus, similarity to pir|B35384 (50%). This apparatus is responsible for the stabilization, translocation and assembly of the monomeric pilin subunits into the pilus organelle. InterPro (IPR001992): Bacterial type II secretion system protein. InterPro (IPR003004): Bacterial general secretion pathway protein F Pfam (PF00482): Bacterial type II secretion system protein TMHMM reporting three TMH; High confidence in function and specificity.
       0.512
dsbC
Putative protein disulfide-isomerase; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process; Belongs to the thioredoxin family. DsbC subfamily.
 
     0.493
azo3229
Putative hydrolase; Probable Hydrogenase expression/formation protein hupH. SIMILARITY:Belongs to the hupH/hyaF family SPROT:P48340: 37% identity, 54% similarity InterPro: IPR002725; DUF45. Pfam: PF01863; DUF45 Nonsecretory protein (Signal P predicted) No transmembrane helices (TMHMM predicted); High confidence in function and specificity.
       0.478
pilD
Prepilin peptidase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.
       0.471
gloA2
Lactoylglutathione lyase; Glyoxalase I catalyzes the first step of the glyoxal pathway. S-lactoylglutathione is then converted by glyoxalase II to lactic acid. Similar to trembl|Q9HY85 (74%) and to sprot|LGUL_NEIMA (70%). Pfam (PF00903): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily ProDom (PD002334): Glyoxalase I; High confidence in function and specificity.
       0.446
azo3358
Hypothetical membrane protein. No real homology of the entire protein to the data bank. no domains predicted no signal peptide 1TMH.
  
    0.406
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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