STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pilCType 4 pilus biogenesis protein; Pilus assembly protein PilC is a component of the pilus biogenesis apparatus, similarity to pir|B35384 (50%). This apparatus is responsible for the stabilization, translocation and assembly of the monomeric pilin subunits into the pilus organelle. InterPro (IPR001992): Bacterial type II secretion system protein. InterPro (IPR003004): Bacterial general secretion pathway protein F Pfam (PF00482): Bacterial type II secretion system protein TMHMM reporting three TMH; High confidence in function and specificity. (411 aa)    
Predicted Functional Partners:
pilB2
Pilus assembly protein PilB is a component of the pilus biogenesis apparatus,; High confidence in function and specificity.
 
 
 0.985
pilD
Prepilin peptidase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.
 
  
 0.962
azo3328
General secretion pathway protein E,; Specificity unclear.
 
 
 0.949
gspE1
Bacterial type II secretion system protein E,; Specificity unclear.
 
 
 0.941
gspE2
General secretion pathway protein E (Type II traffic warden ATPase) INVOLVED IN A GENERAL SECRETION PATHWAY (GSP) FOR THE EXPORT OF PROTEINS. Similar to sprot|PILF_NEIGO (33%) and trembl|Q82U87 (54%). InterPro (PF00437): Bacterial type II secretion system protein E InterPro (PS50101): ATP/GTP-binding site motif A (P-loop); Specificity unclear.
 
 
 0.941
gspE3
General secretion pathway protein E,; Specificity unclear.
 
 
 0.941
pilM
Type 4 fimbrial biogenesis protein PilM, similarity to trembl|Q82SK1 (56%)and to pir|S77726 (47%). Four genes,pilM-P, encode the necessary proteins and pilM is required for the assembly of the type IV fimbriae in Pseudomonas aeruginosa; Specificity unclear.
 
 
 
 0.880
pilT
Twitching motility protein; Tfp retraction protein PilT, involved in the twitching motility mechanism together with PilU,; High confidence in function and specificity.
 
   
 0.810
pilA
Tfp structural protein; PilA encodes an unusually short (6.4 kDa)putative pilin precursor showing 100% sequence identity to the conserved N-terminus of the Pseudomonas aeruginosa type IV pilin. (Reference: Doerr et al., 1998 Molecular Microbiology); High confidence in function and specificity.
 
  
 0.801
pilQ
Type 4 fimbrial biogenesis protein PilQ, similarity to sprot|PILQ_PSEAE (41%) and trembl|Q8XV60 (45%). PilQ is essential for the biogenesis of type IV pili. Its precise function is unknown, but it has been suggested that it may act as a pilus channel in the final stages of pilus assembly. InterPro (PF00263): General (type II) secretion pathway (GSP) D protein SignalP reporting signal peptide; Specificity unclear.
 
 
 
 0.795
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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