STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pilDPrepilin peptidase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. (283 aa)    
Predicted Functional Partners:
pilC
Type 4 pilus biogenesis protein; Pilus assembly protein PilC is a component of the pilus biogenesis apparatus, similarity to pir|B35384 (50%). This apparatus is responsible for the stabilization, translocation and assembly of the monomeric pilin subunits into the pilus organelle. InterPro (IPR001992): Bacterial type II secretion system protein. InterPro (IPR003004): Bacterial general secretion pathway protein F Pfam (PF00482): Bacterial type II secretion system protein TMHMM reporting three TMH; High confidence in function and specificity.
 
  
 0.962
pilB2
Pilus assembly protein PilB is a component of the pilus biogenesis apparatus,; High confidence in function and specificity.
 
 
 0.948
azo3328
General secretion pathway protein E,; Specificity unclear.
 
 
 0.869
gspF1
General secretion pathway protein F; Type II secretory pathway component F,; Specificity unclear.
 
  
 0.866
gspF2
General secretion pathway protein F,similar trembl|Q88HD6 (39%). The general (type II) secretion pathway (GSP) within Gram-negative bacteria is a signal sequence-dependent process responsible for protein export. The process has two stages: exoproteins are first translocated across the inner membrane by the general signal-dependent export pathway (GEP), and then across the outer membrane by a species-specific accessory mechanism. InterPro (IPR001992): Bacterial type II secretion system protein. InterPro (IPR003004): Bacterial general secretion pathway protein F Pfam (PF00482): Bacterial [...]
 
  
 0.864
pilT
Twitching motility protein; Tfp retraction protein PilT, involved in the twitching motility mechanism together with PilU,; High confidence in function and specificity.
 
   
 0.861
gspE3
General secretion pathway protein E,; Specificity unclear.
 
 
 0.858
gspE2
General secretion pathway protein E (Type II traffic warden ATPase) INVOLVED IN A GENERAL SECRETION PATHWAY (GSP) FOR THE EXPORT OF PROTEINS. Similar to sprot|PILF_NEIGO (33%) and trembl|Q82U87 (54%). InterPro (PF00437): Bacterial type II secretion system protein E InterPro (PS50101): ATP/GTP-binding site motif A (P-loop); Specificity unclear.
 
 
 0.856
gspE1
Bacterial type II secretion system protein E,; Specificity unclear.
 
 
 0.851
comA
Putative DNA uptake/competence protein; Competence protein comA. Essential for natural transformation. Could be a transporter involved in DNA uptake. InterPro: DNA internalization-related competence protein ComEC/Rec2 function: transporter activity TREMBL:Q82SD2: 38% identity,50% similarity. InterPro:IPR001279; Blactmase-like. IPR004477; ComEC_N-term. IPR004797; ComEC_Rec2. Pfam PF03772; Competence; 1. PF00753; Lactamase_B; 1. TIGRFAMs:TIGR00360; ComEC_N-term; 1. TIGR00361; ComEC_Rec2; ComEC_Rec2: DNA internalization-relate TMHMM predicted 8 transmembrane helices; High confidence in fu [...]
 
  
 0.831
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
Server load: medium (48%) [HD]
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