STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
azo3295Putative Cytochrome aa3 oxidase assembly protein,42% Identity to TrEMBL;Q7P0G1, Q62F60. Has PF02628,Cytochrome oxidase assembly protein; IPR003780,COX15_CtaA; This is a family of integral membrane proteins. CtaA is required for cytochrome aa3 oxidase assembly in Bacillus subtilis. COX15 is required for cytochrome c oxidase assembly in yeast (P40086). (347 aa)    
Predicted Functional Partners:
coxD
Putative protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
 
 0.999
coxB
Conserved hypothetical cytochrome c oxidase,subunit II; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).
 
 
 0.995
azo3297
Conserved hypothetical secreted protein. Homology to NE1012 of N.europaea of 31% (tremble:Q82VQ4). No domains predicted. Signal peptide present. No TMHs; Conserved hypothetical protein.
 
 
 0.994
coxC
Cytochrome c oxidase polypeptide III Subunits I II and III form the functional core of the enzyme complex. InterPro: Cytochrome c oxidase subunit III; High confidence in function and specificity.
 
 
 0.993
coxG
CoxG protein; Cytochrome c oxidase assembly protein ctaG. Exerts its effect at some terminal stage of cytochrome c oxidase synthesis probably by being involved in the insertion of the copper B into subunit I (By similarity); High confidence in function and specificity.
 
 0.991
coxA
Probable cytochrome c oxidase, subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
 
 
 0.987
azo3296
Conserved hypothetical membrane protein. Homology to RS03338 of Ralstonia solanacearum of 36% (trembl|Q8Y2G6(SRS)). No domains predicted. No signal peptide. 1 TMHs; Conserved hypothetical protein.
 
 
 0.974
senC
SCO1/SenC family protein; SCO2 protein homolog mitochondrial precursor. Acts as a copper chaperone transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2). InterPro: SCO1/SenC TREMBL:Q8Y2G3: 56% identity, 74% similarity InterPro:IPR003782; SCO1_SenC. Pfam: PF02630; SCO1-SenC dsbE: periplasmic protein thiol:disulf Presence of signal peptide (SignalP predicted) No TMH's present; Family membership.
 
 
 0.905
FtsY
Probable signal recognition particle-docing protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
 
 
  
 0.902
petC
Conserved hypothetical ubiquinol-cytochrome c reductase cytochrome c1 protein. Homology to petC of R. solanacearum of 52% (trembl|Q8XVA4). Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. c1 functions as an electron donor to cytochrome c. InterPro: Cytochrome c1 (IPR002326) Pfam: Cytochrome_c1 signal peptide 1 TMH; Conserved hypothetical protein.
 
 0.840
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.