| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ackA | acsB | azo3639 | azo2414 | Probable acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | Probable acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.941 |
| ackA | cat1 | azo3639 | azo3307 | Probable acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | Probable coenzyme A transferase. Homology to cat1 of C. kluyveri of 51% (sprot|CAT1_CLOKL). Pfam: Acetyl-CoA hydrolase/transferase no signal peptide no TMHs tal_mycobact: transaldolase; Family membership. | 0.887 |
| ackA | icmF | azo3639 | azo0696 | Probable acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | Probable methylmalonyl-coa mutase protein; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. | 0.412 |
| ackA | mutB | azo3639 | azo0685 | Probable acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | Probable Methylmalonyl-CoA mutase large subunit; FUNCTION: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates (By similarity). ACtivity:- (R)-2-Methylmalonyl-CoA = succinyl-CoA Entry name :- MUTB_PORGI Primary accession number :-Q59677 Identities = 467/679 (68%) InterPro :-IPR006159; Acid_CoA_mut_C. IPR006158; B12-binding. IPR006099; MMCoA_mutase. IPR006098; MMCoA_mutase_N. IPR006100; MMCoA_mutase_sub. Pfam PF02310; B12-binding; 1. PF01642; MM_CoA_mutase; 1. Prediction: Non-secretory protein Signal [...] | 0.412 |
| ackA | odhB | azo3639 | azo1556 | Probable acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | Dihydrolipoamide S-succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | 0.422 |
| ackA | pta | azo3639 | azo3638 | Probable acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | Conserved hypothetical phosphate acetyltransferase. Homology to pta of R. palustris of 63% (tremblnew|CAE30007). InterPro: Phosphate acetyl/butaryl transferase (IPR002505); MaoC-like dehydrogenase domain (IPR002539). Pfam: MaoC like domain; Phosphate acetyl/butaryl transferase. no signal peptide. no TMHs; Conserved hypothetical protein. | 0.999 |
| ackA | sucC | azo3639 | azo3333 | Probable acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | Probable succinyl-CoA synthetase, beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.655 |
| ackA | sucD | azo3639 | azo3332 | Probable acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | Probable succinyl-CoA synthetase, alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.639 |
| acsB | ackA | azo2414 | azo3639 | Probable acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Probable acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | 0.941 |
| acsB | cat1 | azo2414 | azo3307 | Probable acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Probable coenzyme A transferase. Homology to cat1 of C. kluyveri of 51% (sprot|CAT1_CLOKL). Pfam: Acetyl-CoA hydrolase/transferase no signal peptide no TMHs tal_mycobact: transaldolase; Family membership. | 0.896 |
| acsB | odhB | azo2414 | azo1556 | Probable acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Dihydrolipoamide S-succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | 0.513 |
| acsB | pta | azo2414 | azo3638 | Probable acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Conserved hypothetical phosphate acetyltransferase. Homology to pta of R. palustris of 63% (tremblnew|CAE30007). InterPro: Phosphate acetyl/butaryl transferase (IPR002505); MaoC-like dehydrogenase domain (IPR002539). Pfam: MaoC like domain; Phosphate acetyl/butaryl transferase. no signal peptide. no TMHs; Conserved hypothetical protein. | 0.944 |
| acsB | sdhB | azo2414 | azo1552 | Probable acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Succinate dehydrogenase, iron-sulfur subunit. Homology to sdhB of C. burnetii of 59% (sprot|DHSB_COXBU). InterPro: Succinate dehydrogenase/fumarate reductase iron-sulfur protein (IPR004489); 4fe-4S ferredoxin, iron-sulfur binding domain (IPR001450); Ferredoxin (IPR1041) Pfam: 2Fe-2S iron-sulfur cluster binding domain Tigrfam: dhsB: succinate dehydrogenase and fumarat reductase iron-sulfur protein no TMHs; High confidence in function and specificity. | 0.408 |
| acsB | sucC | azo2414 | azo3333 | Probable acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Probable succinyl-CoA synthetase, beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.888 |
| acsB | sucD | azo2414 | azo3332 | Probable acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Probable succinyl-CoA synthetase, alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.881 |
| acsB | thlA | azo2414 | azo2172 | Probable acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Acetyl-CoA acetyltransferase (Acetoacetyl-CoA thiolase):- catalytic activity:-2 acetyl-coa = coa + acetoacetyl-coa. Entry name SWISSPROT:THLA_CLOAB Prim. accession # P45359 Identities = 205/392 (52%) InterPro IPR002155; Thiolase. Pfam PF00108; thiolase; 1. Prediction: Non-secretory protein Signal peptide probability: 0.022 Number of predicted TMHs: 0; Family membership; Belongs to the thiolase-like superfamily. Thiolase family. | 0.876 |
| cat1 | ackA | azo3307 | azo3639 | Probable coenzyme A transferase. Homology to cat1 of C. kluyveri of 51% (sprot|CAT1_CLOKL). Pfam: Acetyl-CoA hydrolase/transferase no signal peptide no TMHs tal_mycobact: transaldolase; Family membership. | Probable acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | 0.887 |
| cat1 | acsB | azo3307 | azo2414 | Probable coenzyme A transferase. Homology to cat1 of C. kluyveri of 51% (sprot|CAT1_CLOKL). Pfam: Acetyl-CoA hydrolase/transferase no signal peptide no TMHs tal_mycobact: transaldolase; Family membership. | Probable acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.896 |
| cat1 | icmF | azo3307 | azo0696 | Probable coenzyme A transferase. Homology to cat1 of C. kluyveri of 51% (sprot|CAT1_CLOKL). Pfam: Acetyl-CoA hydrolase/transferase no signal peptide no TMHs tal_mycobact: transaldolase; Family membership. | Probable methylmalonyl-coa mutase protein; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. | 0.934 |
| cat1 | mutB | azo3307 | azo0685 | Probable coenzyme A transferase. Homology to cat1 of C. kluyveri of 51% (sprot|CAT1_CLOKL). Pfam: Acetyl-CoA hydrolase/transferase no signal peptide no TMHs tal_mycobact: transaldolase; Family membership. | Probable Methylmalonyl-CoA mutase large subunit; FUNCTION: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates (By similarity). ACtivity:- (R)-2-Methylmalonyl-CoA = succinyl-CoA Entry name :- MUTB_PORGI Primary accession number :-Q59677 Identities = 467/679 (68%) InterPro :-IPR006159; Acid_CoA_mut_C. IPR006158; B12-binding. IPR006099; MMCoA_mutase. IPR006098; MMCoA_mutase_N. IPR006100; MMCoA_mutase_sub. Pfam PF02310; B12-binding; 1. PF01642; MM_CoA_mutase; 1. Prediction: Non-secretory protein Signal [...] | 0.943 |
